Pharmacological inhibition of IRAP as a novel antifibrotic strategy
Pharmacological inhibition of IRAP as a novel antifibrotic strategy
批准号:
nhmrc : 1146049
负责人:
A/Pr Chrishan Samuel
金额:
$70.07万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 2021-12-31
中文摘要
很少有治疗方法可以减少心脏僵硬,称为纤维化,这在高血压患者或心脏病发作的患者中可见。这个项目将测试我们开发的新药,这些新药通过一种独特的机制来逆转或预防心脏和血管功能不佳患者的心血管疾病。
英文摘要
There are very few treatments that can reduce heart stiffening, called fibrosis, which is seen in patients with high blood pressure or in patients who have had a heart attack. This project will test new drugs that we have developed that act by a unique mechanism to reverse or prevent cardiovascular disease in patients with poorly-functioning hearts and blood vessels.
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Pharmacological inhibition of IRAP as a novel antifibrotic strategy
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批准号:nhmrc : GNT1146049
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项目类别:Project Grants
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资助金额:$103.64万
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财政年份:2018
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负责人:A/Pr Chrishan Samuel
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依托单位:
Unraveling fibrosis by pharmacological targeting of the G protein-coupled receptor, RXFP1
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批准号:nhmrc : GNT1122170
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项目类别:Project Grants
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资助金额:$79.86万
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财政年份:2017
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负责人:A/Pr Chrishan Samuel
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依托单位:
Unraveling fibrosis by pharmacological targeting of the G protein-coupled receptor, RXFP1
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批准号:nhmrc : 1122170
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项目类别:Project Grants
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资助金额:$54.45万
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财政年份:2017
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负责人:A/Pr Chrishan Samuel
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依托单位:
Understanding the cardio-protective actions of the AT2R in females: Shifting gears between AT1 and AT2 receptor balance of function with relaxin.
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批准号:nhmrc : GNT1101552
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项目类别:Project Grants
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资助金额:$104.93万
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财政年份:2016
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负责人:A/Pr Chrishan Samuel
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依托单位:
Understanding the cardio-protective actions of the AT2R in females: Shifting gears between AT1 and AT2 receptor balance of function with relaxin.
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批准号:nhmrc : 1101552
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项目类别:Project Grants
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资助金额:$72.15万
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财政年份:2016
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负责人:A/Pr Chrishan Samuel
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依托单位:
Tubulointerstitial Epigenetics- The Underlying Basis of Progressive Fibrosis in Kidney Disease
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批准号:nhmrc : 1078694
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项目类别:Project Grants
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资助金额:$25.27万
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财政年份:2015
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负责人:A/Pr Chrishan Samuel
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依托单位:
Tubulointerstitial Epigenetics- The Underlying Basis of Progressive Fibrosis in Kidney Disease
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批准号:nhmrc : GNT1078694
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项目类别:Project Grants
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资助金额:$36.71万
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财政年份:2015
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负责人:A/Pr Chrishan Samuel
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依托单位:
Developing Relaxin Peptides as Novel Therapies for Fibrosis
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批准号:nhmrc : 1041766
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项目类别:Research Fellowships
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资助金额:$50.1万
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财政年份:2013
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负责人:A/Pr Chrishan Samuel
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依托单位:
Developing Novel Therapies for Fibrosis
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批准号:nhmrc : GNT1041766
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项目类别:Research Fellowships
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资助金额:$59.08万
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财政年份:2013
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负责人:A/Pr Chrishan Samuel
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依托单位:
Relaxin therapy reverses large artery remodelling and stiffening in aged and hypertensive models
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批准号:nhmrc : 1004235
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项目类别:Project Grants
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资助金额:$29.67万
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财政年份:2011
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负责人:A/Pr Chrishan Samuel
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依托单位:
Molecular mechanisms of renal fibrosis
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批准号:nhmrc : 628634
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项目类别:NHMRC Project Grants
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资助金额:$25.0万
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财政年份:2010
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负责人:A/Pr Chrishan Samuel
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依托单位:
Novel Candidate Genes, Lung Function and Allergic Airways Disease
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批准号:nhmrc : 546428
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项目类别:NHMRC Project Grants
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资助金额:$38.8万
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财政年份:2009
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负责人:A/Pr Chrishan Samuel
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依托单位:
Investigating the anti-fibrotic properties of relaxin in the normal and diseased heart
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批准号:nhmrc : 454636
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项目类别:Career Development Fellowships
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资助金额:$31.95万
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财政年份:2007
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负责人:A/Pr Chrishan Samuel
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依托单位:
国内基金
海外基金
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