Understanding the cardio-protective actions of the AT2R in females: Shifting gears between AT1 and AT2 receptor balance of function with relaxin.

了解 AT2R 对女性的心脏保护作用：通过松弛素在 AT1 和 AT2 受体功能平衡之间切换。

• 批准号: nhmrc : 1101552
• 负责人: A/Pr Chrishan Samuel
• 金额: $ 72.15万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-cardio-protective-function-relaxin/662554
• 关键词: Understanding; cardio; protective; actions; AT2R

Women are protected from cardiovascular disease as compared to age-matched men, an effect lost with age. Understanding protective factors that act in females could be used to treat hypertension, heart failure and stroke in males at all ages, and maintain protection in elderly women. Our studies aim to determine if relaxin, an ovarian hormone, can promote cardiovascular health in women.

与年龄相当的男性相比，妇女免受心血管疾病的影响，这种影响随着年龄的增长而消失。了解在女性中起作用的保护因素可用于治疗所有年龄段男性的高血压、心力衰竭和中风，并维持对老年女性的保护。我们的研究旨在确定松弛素，一种卵巢激素，是否可以促进女性心血管健康。