SYNTHESIS OF ELECTROCHEMICAL ENTITIES

电化学实体的合成

基本信息

  • 批准号:
    8361347
  • 负责人:
  • 金额:
    $ 2.18万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-01-01 至 2011-12-31
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Because electrochemistry allows one to selectively manipulate the oxidation state of molecules, create reactive intermediates, and reverse the polarity of known functional groups, it provides and ideal method for discovering and exploring many new, synthetically useful reactions. For example, we have found that the anodic oxidation of electron-rich olefins leads to the formation of radical cations that efficiently trap nucleophiles. In this way, normally nucleophilic enolate equivalents can be used as electrophiles. Current efforts to exploit this unique umpolung reaction are focusing on the construction of natural products. In a similar fashion, we are taking advantage electrochemistry's ability to reverse the normal polarity of N-acyliminium ion formation in order to develop new approaches to diversity-oriented synthesis that allow for systematic variations within a core scaffold to synthesize receptor-targeted molecular libraries that contain conformational probes for rapidly gathering information about the three dimensional requirements of the receptor, and to construct new peptide-based bioconjugates.
这个子项目是利用这些资源的众多研究子项目之一

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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KEVIN David MOELLER其他文献

KEVIN David MOELLER的其他文献

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{{ truncateString('KEVIN David MOELLER', 18)}}的其他基金

SYNTHESIS OF ELECTROCHEMICAL ENTITIES
电化学实体的合成
  • 批准号:
    8168697
  • 财政年份:
    2010
  • 资助金额:
    $ 2.18万
  • 项目类别:
SYNTHESIS OF ELECTROCHEMICAL ENTITIES
电化学实体的合成
  • 批准号:
    7953907
  • 财政年份:
    2009
  • 资助金额:
    $ 2.18万
  • 项目类别:
SYNTHESIS OF ELECTROCHEMICAL ENTITIES
电化学实体的合成
  • 批准号:
    7721468
  • 财政年份:
    2008
  • 资助金额:
    $ 2.18万
  • 项目类别:
SYNTHESIS OF ELECTROCHEMICAL ENTITIES
电化学实体的合成
  • 批准号:
    7355290
  • 财政年份:
    2006
  • 资助金额:
    $ 2.18万
  • 项目类别:
INTRAMOLECULAR ANODIC OLEFIN COUPLING REACTIONS
分子内阳极烯烃偶联反应
  • 批准号:
    7180103
  • 财政年份:
    2005
  • 资助金额:
    $ 2.18万
  • 项目类别:
INTRAMOLECULAR ANODIC OLEFIN COUPLING REACTIONS
分子内阳极烯烃偶联反应
  • 批准号:
    6977086
  • 财政年份:
    2003
  • 资助金额:
    $ 2.18万
  • 项目类别:
(NSF) INTRAMOLECULAR ANODIC OLEFIN COUPLING REACTIONS
(NSF) 分子内阳极烯烃偶联反应
  • 批准号:
    6665868
  • 财政年份:
    2002
  • 资助金额:
    $ 2.18万
  • 项目类别:
(NSF) INTRAMOLECULAR ANODIC OLEFIN COUPLING REACTIONS
(NSF) 分子内阳极烯烃偶联反应
  • 批准号:
    6486748
  • 财政年份:
    2001
  • 资助金额:
    $ 2.18万
  • 项目类别:
(NSF) INTRAMOLECULAR ANODIC OLEFIN COUPLING REACTIONS
(NSF) 分子内阳极烯烃偶联反应
  • 批准号:
    6336818
  • 财政年份:
    2000
  • 资助金额:
    $ 2.18万
  • 项目类别:
(NIH) NOVEL SYNTHETIC APPROACHES TO RIGID PEPTIDE ANALOGS
(NIH) 刚性肽类似物的新颖合成方法
  • 批准号:
    6118566
  • 财政年份:
    1998
  • 资助金额:
    $ 2.18万
  • 项目类别:

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