SYNTHESIS OF ELECTROCHEMICAL ENTITIES

电化学实体的合成

• 批准号: 8168697
• 负责人: KEVIN David MOELLER
• 金额: $ 1.64万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-10 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168697
• 关键词: Alkenes; Biological Factors; Cations; Computer Retrieval of Information on Scientific Projects Database; Electrochemistry; Electrons; Funding; Grant; Institution; Ions; Methods; Molecular Bank; Peptides; Reaction; Research; Research Personnel; Resources; Source; United States National Institutes of Health; Variant; base; enolate; functional group; information gathering; novel strategies; oxidation; receptor; scaffold

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Because electrochemistry allows one to selectively manipulate the oxidation state of molecules, create reactive intermediates, and reverse the polarity of known functional groups, it provides and ideal method for discovering and exploring many new, synthetically useful reactions. For example, we have found that the anodic oxidation of electron-rich olefins leads to the formation of radical cations that efficiently trap nucleophiles. In this way, normally nucleophilic enolate equivalents can be used as electrophiles. Current efforts to exploit this unique umpolung reaction are focusing on the construction of natural products. In a similar fashion, we are taking advantage electrochemistry's ability to reverse the normal polarity of N-acyliminium ion formation in order to develop new approaches to diversity-oriented synthesis that allow for systematic variations within a core scaffold to synthesize receptor-targeted molecular libraries that contain conformational probes for rapidly gathering information about the three dimensional requirements of the receptor, and to construct new peptide-based bioconjugates.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 由于电化学允许人们选择性地操纵分子的氧化态、产生反应性中间体并逆转已知官能团的极性，因此它为发现和探索许多新的、合成有用的反应提供了理想的方法。 例如，我们发现富电子烯烃的阳极氧化导致形成有效捕获亲核试剂的自由基阳离子。以这种方式，通常亲核烯醇化物等价物可以用作亲电子试剂。目前利用这种独特的uppolung反应的努力集中在天然产物的构建上。 以类似的方式，我们正在利用电化学的能力，以扭转正常极性的N-酰基异氰尿酸离子的形成，以开发新的方法，以多样性为导向的合成，允许系统的变化内的核心支架，以合成受体靶向分子库，其中包含构象探针，用于快速收集信息的三维需求的受体，并构建新的基于肽的生物缀合物。