Miami Center for Vision Research

描述（由申请人提供）：迈阿密视觉研究中心（MCVR）汇集了迈阿密大学的87名教师级研究人员，以整合视觉系统及其疾病的细胞、分子、功能、解剖、生物物理、计算和临床方面的专业知识。迈阿密团队包括29名NEI资助的首席研究员-其中20人持有合格的NEI赠款- 8 NEI分包合同和4 NEI补充。目前正在审查五项NEI-R 01赠款。71名MCVR研究人员在迈阿密大学米勒医学院的巴斯科姆帕尔默眼科研究所担任主要职务，大部分研究空间位于八层楼高的Evelyn F.和William L.麦克奈特视觉研究中心。额外的空间位于邻近的罗森斯蒂尔大楼、临床研究大楼和生物医学研究大楼。我们请求继续支持视觉研究核心补助金，其具体目标是：1）提供和维持核心资源设施，以提高研究的速度和质量，2）促进来自不同学科的研究人员之间的合作研究，3）吸引研究人员研究视觉系统及其疾病，4）帮助研究人员收集新的NIH补助金提案的数据。核心补助金将支持5个模块：1）共享设备设施-提供超出单个实验室范围的仪器，2）生物统计学-提供研究设计和数据分析的专业知识，3）实验模型-提供实验模型，手术室和专业程序的专业知识和服务，4）组织学和组织处理-支持通过光学显微镜观察和分析的生物标本的处理，以及5）成像-支持共聚焦显微镜，延时显微镜和立体显微镜。巴斯科姆帕尔默眼科研究所将支持更多的共享资源，包括：6）眼科生物物理中心-咨询，维护和建设特设仪器; 7）临床微生物实验室-提供服务的临床和基础研究的需要; 8）玛丽和爱德华诺顿图书馆-住房的世界上最大的收藏对眼科的主题。

DESCRIPTION (provided by applicant): The Miami Center for Vision Research (MCVR) draws together 87 faculty level investigators across the University of Miami to integrate expertise on cellular, molecular, functional, anatomical, biophysical, computational, and clinical aspects of the visual system and its disorders. The Miami Team includes 29 NEI funded Principal Investigators - 20 of them holding qualifying NEI grants - 8 NEI subcontracts and 4 NEI supplements. Five NEI-R01 grants are currently under review. Seventy-one MCVR investigators hold primary appointments in the Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, and most of the research space is located within the eight-story Evelyn F. and William L. McKnight Vision Research Center. Additional space is located in the adjacent Rosenstiel building, Clinical Research Building, and Biomedical Research Building. We request continuing support for a Vision Research Core Grant whose specific aims are: 1) to provide and sustain core resource facilities to enhance the pace and quality of research, 2) to foster collaborative research among investigators from various disciplines, 3) to attract investigators to research on the visual system and its diseases, 4) to help investigators gathering data for new NIH grant proposals. The core grant will support 5 modules: 1) Shared Equipments Facilities -to provide access to instrumentation beyond the reach of single labs, 2) Biostatistics - to provide expertise on research design and data analysis, 3) Experimental Models - to provide expertise and services on experimental models, operating rooms and specialized procedures, 4) Histology & Tissue Processing - to support the processing of biological specimens for observation and analysis by light microscopy, and 5) Imaging - to support confocal microscopy, time-lapse microscopy and stereomicroscopy. The Bascom Palmer Eye Institute will support additional shared resources including, 6) Ophthalmic Biophysics Center - for consultation, maintenance and construction of ad-hoc instrumentation; 7) Clinical Microbiology Laboratory - providing services for clinical and basic research needs; 8) The Mary & Edward Norton Library - housing the world's largest collection on the subject of ophthalmology.