Biomedical Simulations Resource (BMSR)

生物医学模拟资源 (BMSR)

基本信息

批准号：
8139148
负责人：
David Z D'Argenio
金额：
$ 113.84万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-09-30 至 2013-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8139148
关键词：
Academia Acute Lymphocytic Leukemia Address Adopted Advanced Development Advisory Committees Affinity Affinity Chromatography Algorithms American Amino Acid Sequence Amino Acids Animal Model Antibodies Anticodon Area Asthma Attributes of Chemicals Australia Award Basic Science Basophils Binding Biochemistry Biological Biological Availability Biological Factors Biology Biopolymers Blast Phase Breeding CC chemokine receptor 3 California Cardiovascular system Cell Membrane Permeability Cells Charge Chemical Engineering Chemical Evolution Chemicals Chemistry Chicago Clinic Clinical Trials Code Collaborations Collection Color Commit Communities Complex Computer software Coupled Crystallography Cysteine Cytoskeletal Filaments DNA Data Dengue Dengue Virus Deuterium Development Discipline of Nursing Disease Doctor of Medicine Doctor of Philosophy Drops Drug Prescriptions Drug resistance Economics Educational workshop Electrostatics Employment Endocrine system Engineering Environment Enzymes Eosinophilia Equilibrium Europe Evolution Expenditure Federal Government Floods Freedom Funding Generations Genes Genetic Code Gleevec Goals Growth Human Human Resources Hydrogen Image Immune system In Vitro Individual Industry Infection Institutes Interferon Receptor Interferons Journals Kilogram Kinetics Knockout Mice Knowledge Knowledge acquisition Laboratories Lead Learning Left Leucine Enkephalin Libraries Ligand Binding Ligands Literature Maps Massachusetts Measurement Measures Medical Medical Research Medicine Membrane Metabolic Methodology Methods Modeling Modification Molecular Molecular Biology Monitor Mus Myelogenous NMR Spectroscopy NS2-3 protease Names Nature Nonlinear Dynamics Nucleic Acids Oral Organic Chemistry Organic Synthesis Organism Pathway interactions Patients Peptide Nucleic Acids Peptide Sequence Determination Peptide aptamers Peptides Persons Phage Display Pharmaceutical Preparations Pharmacologic Substance Phase Phosphotransferases Physiological Physiology Pilot Projects Plasmids Polyribosomes Polystyrenes Population Positioning Attribute Positron-Emission Tomography Postdoctoral Fellow Price Primates Principal Investigator Probability Problem Solving Process Productivity Professional Education Property Protease Inhibitor Protein Footprinting Protein Tyrosine Kinase Proteins Protons Publications RNA Reaction Reagent Records Research Research Infrastructure Research Personnel Research Project Grants Resistance Resolution Resources Rotation Running SCID Mice Scheme Science Scientist Screening for cancer Screening procedure Secure Series Services Shapes Signal Transduction Societies Solid Solvents Specificity Speed Staging Structure Students System T-Cell Receptor Techniques Technology Test Result Testing Therapeutic Training Transcend Translating Translation Process Translational Research Translations Triose-Phosphate Isomerase Trust Tube Tyrosine United States Universities Variant Vertebral column Work Zebrafish airway hyperresponsiveness anticancer research aptamer base catalyst cell type clinical practice combinatorial chemistry cost data modeling design drug development drug discovery empowered eosinophil eotaxin receptor experience falls genetic manipulation graduate student high risk high throughput screening inhibitor/antagonist innovation insight interleukin-5 receptor kinase inhibitor knowledge base leukemia macromolecule medical schools millisecond models and simulation molecular mechanics molecular recognition mouse model multidisciplinary mutant new technology news novel olfactory receptor peer post-doctoral training pre-clinical professor programs protein protein interaction protein structure quantum receptor relating to nervous system research and development respiratory routine practice sensor simulation simulation software small molecule small molecule libraries structural biology technology development three dimensional structure tool trend user friendly software

项目摘要

Biomedical Simulations Resources (BMSR) at the University of Southern California is dedicated to the advancement of the state-of-the-art in biomedical modeling and simulation through Technological Research and Development (Core) and Collaborative Research projects. It also seeks the dissemination of this knowledge and related software through Service, Training and Dissemination activities aimed at the biomedical community at large. The latter activities include distribution and support of modeling/simulation software, as well as the organization of related short-courses and workshops in addition to publication of research volumes and publications in open literature. The emphasis of the Core Research projects is on development of advanced modeling and simulation methodologies and their application to biomedical systems for the advancement of scientific knowledge and the improvement of clinical practice. The challenging cases of nonlinear dynamic systems, sparse data modeling, closed-loop physiological modeling/control and modeling of multi-variable complex systems, constitute the focal points of this effort. The methodologies developed by the Core projects are at the cutting-edge of research in this area and are made possible by the aggregation of human resources and computing facilities within the BMSR. Pivotal applications of these methodologies cover a variety of physiological domains, including pharmacokinetics, neural/cognitive, neurovascular, neurological, cardio-vascular, cardio-respiratory, hemodynamic, metabolic and endocrine systems. Additional applications, serving as testing grounds and dissemination means for the developed methodologies, take place in our Collaborative projects. Fully developed and tested methodologies are implemented in software packages and made available to the biomedical community at large free of charge. The Service, Training and Dissemination activities of the BMSR seek to promote the dissemination of knowledge and technology in the area of biomedical modeling and simulation in order to create a productive and interactive community of investigators that can provide the multi-disciplinary scientific/technological impetus needed to transcend the barriers imposed by the complexity of the subject. The ultimate objective of the BMSR is to facilitate the development and broad use of novel modeling and simulation methodology/technology for scientific advancement and improvement of our health care system. A particular thrust of the proposed five-year program is our translational work that seeks to transfer our novel methodology/technology to the clinical setting as the capstone achievement of the BMSR.

南加州大学的生物医学模拟资源（BMSR）致力于通过技术研发（CORE）和协作研究项目提高生物医学建模和仿真的最先进。它还通过针对整个生物医学界的服务，培训和传播活动来寻求传播这些知识和相关软件。后者的活动包括建模/仿真软件的分发和支持，以及相关的肖像和讲习班的组织，除了发表开放文献中的研究量和出版物。核心研究项目的重点是开发先进的建模和模拟方法及其在生物医学系统中的应用，以提高科学知识和改善临床实践。非线性动态系统，稀疏数据建模，闭环生理建模/控制和多变量复杂系统建模的挑战性案例构成了这项工作的焦点。核心项目开发的方法是在该领域的研究的前沿，并且通过BMSR内的人力资源和计算设施的汇总使其成为可能。这些方法的关键应用涵盖了多种生理领域，包括药代动力学，神经/认知，神经血管，神经系统，心脏血管，心脏呼吸，血液动力学，代谢和内分泌系统。我们的协作项目中进行了其他应用程序，作为测试理由和传播手段。完全开发和测试的方法可以在软件包中实现，并可以免费提供给生物医学界的方法。 BMSR的服务，培训和传播活动旨在促进生物医学建模和模拟领域中知识和技术的传播，以创建一个富有生产力的研究人员社区，这些社区可以为越过该主题的复杂性所带来的障碍所需的多学科科学/技术动力。 BMSR的最终目标是促进新型建模和模拟方法/技术的开发和广泛使用，以进行科学进步和改善我们的医疗保健系统。拟议的五年计划的一个特殊推力是我们的翻译工作，该工作旨在将我们的新方法/技术转移到临床环境中，作为BMSR的顶峰实现。