Biomedical Simulations Resource (BMSR)

生物医学模拟资源 (BMSR)

基本信息

批准号：
8926416
负责人：
David Z D'Argenio
金额：
$ 125.51万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-09-30 至 2016-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8926416
关键词：
Achievement Address Advanced Development Area Behavioral Biological Markers Biological Models Biological Process Biomedical Research Blood Vessels California Charge Clinical Clinical Research Cognitive Communication Communities Complex Computer software Data Analyses Development Diagnosis Diagnostic Disease Disease Clusterings Drug Kinetics Educational workshop Endocrine system Generations Goals Health Healthcare Systems Human Human Resources Information Systems Knowledge Literature Metabolic Methodology Methods Modeling Neurologic Nonlinear Dynamics Pharmacologic Substance Physiological Publications Research Research Activity Research Personnel Research Project Grants Resources Role Sensitivity and Specificity Services System Technology Testing Training Transcend Translational Research Universities Vision Work advanced system base biomedical resource clinical Diagnosis clinical practice cost data modeling design hemodynamics human disease improved innovation models and simulation molecular scale novel programs public health relevance relating to nervous system research and development respiratory simulation simulation software symposium tool trend web site

项目摘要

DESCRIPTION (provided by applicant): Biomedical Simulations Resources (BMSR) at the University of Southern California is dedicated to the advancement of the state-of-the-art in biomedical modeling and simulation through Technological Research and Development (Core) and Collaborative Research projects. It also seeks the dissemination of this knowledge and related software through Service, Training and Dissemination activities aimed at the biomedical community at large. The latter activities include distribution and support of modeling/simulation software, as well as the organization of related short-courses and workshops in addition to publication of research volumes and publications in open literature. The emphasis of the Core Research projects is on development of advanced modeling and simulation methodologies and their application to biomedical systems for the advancement of scientific knowledge and the improvement of clinical practice. The challenging cases of nonlinear dynamic systems, sparse data modeling, closed-loop physiological modeling/control and modeling of multi-variable complex systems, constitute the focal points of this effort. The methodologies developed by the Core projects are at the cutting-edge of research in this area and are made possible by the aggregation of human resources and computing facilities within the BMSR. Pivotal applications of these methodologies cover a variety of physiological domains, including pharmacokinetics, neural/cognitive, neurovascular, neurological, cardio-vascular, cardio-respiratory, hemodynamic, metabolic and endocrine systems. Additional applications, serving as testing grounds and dissemination means for the developed methodologies, take place in our Collaborative projects. Fully developed and tested methodologies are implemented in software packages and made available to the biomedical community at large free of charge. The Service, Training and Dissemination activities of the BMSR seek to promote the dissemination of knowledge and technology in the area of biomedical modeling and simulation in order to create a productive and interactive community of investigators that can provide the multi-disciplinary scientific/technological impetus needed to transcend the barriers imposed by the complexity of the subject. The ultimate objective of the BMSR is to facilitate the development and broad use of novel modeling and simulation methodology/technology for scientific advancement and improvement of our health care system. A particular thrust of the proposed five-year program is our translational work that seeks to transfer our novel methodology/technology to the clinical setting as the capstone achievement of the BMSR.

描述（由申请人提供）：南加州大学的生物医学模拟资源（BMSR）致力于通过技术研发（CORE）和协作研究项目的生物医学建模和仿真最先进的发展。它还通过针对整个生物医学界的服务，培训和传播活动来寻求传播这些知识和相关软件。后者的活动包括建模/仿真软件的分发和支持，以及相关的肖像和讲习班的组织，除了发表开放文献中的研究量和出版物。核心研究项目的重点是开发先进的建模和模拟方法及其在生物医学系统中的应用，以提高科学知识和改善临床实践。非线性动态系统，稀疏数据建模，闭环生理建模/控制和多变量复杂系统建模的挑战性案例构成了这项工作的焦点。核心项目开发的方法是在该领域的研究的前沿，并且通过BMSR内的人力资源和计算设施的汇总使其成为可能。这些方法的关键应用涵盖了多种生理领域，包括药代动力学，神经/认知，神经血管，神经系统，心脏血管，心脏呼吸，血液动力学，代谢和内分泌系统。我们的协作项目中进行了其他应用程序，作为测试理由和传播手段。完全开发和测试的方法可以在软件包中实现，并可以免费提供给生物医学界的方法。 BMSR的服务，培训和传播活动旨在促进生物医学建模和模拟领域中知识和技术的传播，以创建一个富有生产力的研究人员社区，这些社区可以为越过该主题的复杂性所带来的障碍所需的多学科科学/技术动力。 BMSR的最终目标是促进新型建模和模拟方法/技术的开发和广泛使用，以进行科学进步和改善我们的医疗保健系统。拟议的五年计划的一个特殊推力是我们的翻译工作，该工作旨在将我们的新方法/技术转移到临床环境中，作为BMSR的顶峰实现。