Anti-inflammatory properties of high-density lipoprotein

高密度脂蛋白的抗炎特性

基本信息

批准号：
8150953
负责人：
Baohai Shao
金额：
$ 24.9万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-08-20 至 2013-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8150953
关键词：
Address Analytical Chemistry Animals Anti-Inflammatory Agents Anti-inflammatory Antioxidants Apolipoproteins A Area Atherosclerosis Award Basic Science Biological Biomedical Research Budgets Cardiovascular Diseases Cell Culture Techniques Cells Cholesterol Collaborations Complex Country Data Development Development Plans Diabetes Mellitus Disease Doctor of Philosophy Environment Equilibrium Faculty Funding Generations Genome Goals Goat Grant High Density Lipoproteins High Pressure Liquid Chromatography Human In Vitro Inflammation Inflammatory Institutes Investigation Journals Knowledge Laboratories Lead Learning Lipids Lipoproteins Medicine Mentors Mentorship Metabolism Modification Molecular Obesity Paper Pathway interactions Peer Review Performance Phase Play Positioning Attribute Postdoctoral Fellow Probability Process Property Protein Chemistry Proteins Proteomics Publishing Relative (related person)Research Research Personnel Research Training Rewards Rodent Model Role Sampling Science Scientist Self Assessment Structure Techniques Testing Time Training United States United States National Institutes of Health Universities Vascular Diseases Washington Work career career development combat diabetic diabetic cardiomyopathy experience human tissue in vivo inhibitor/antagonist instrumentation medical schools member multidisciplinary novel diagnostics novel therapeutic intervention oxidation oxidative damage prevent professor programs research study skills

项目摘要

High-density lipoprotein (HDL) protects against atherosclerosis by removing excess cholesterol from arterial cells. HDL has also been proposed to function as an important Inhibitor of cellular inflammation and lipid oxidation in vivo. Moreover, inflammation has been proposed to convert HDL to a dysfunctional form that loses these cardioprotective effects and may even be pro-inflammatory. Two important pathways may Involve oxidative damage and changes in the relative balance of pro- and antioxidant proteins in HDL. During the first two years of the award, the PI has completed a highly structured career development plan to prepare him for transition to a fully independent investigator. During this time, he has published five first author papers in peer-reviewed journals, that have directly addressed the hypotheses raised in the original proposal. Importantly, he has obtained strong preliminary data in diabetic humans that the proposed mechanisms for generation of dysfunctional HDL are pathophysiologically relevant. In collaboration with translational investigators at the University of Washington, the PI has laid the groundwork for developing a research program centered on understanding the role of HDL in diabetic cardiovascular disease. Importantly, the proposed studies are completely Independent of that of his mentor. He also has accepted a faculty position with the University of Washington and the Department of Medicine has assigned him independent laboratory space and an office at the newly established Diabetes and Obesity Center of Excellence. During the next phase of the K99/R00 award, the PI will focus on two major goals: first, establishing a fully independent research program centered on diabetes and cardiovascular diseases. Second, obtaining NIH funding for his research studies. The long-term goal is to combat atherosclerosis by understanding the molecular mechanisms for generation of dysfunctional HDL in humans suffering from diabetes and other inflammatory conditions.