Investigation of the dopamine system in frontotemporal dementia

额颞叶痴呆中多巴胺系统的研究

• 批准号: 8197820
• 负责人: Edward D Huey
• 金额: $ 23.41万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8197820
• 关键词: Adverse effects; Adverse event; Affect; Alleles; Amendment; Animals; Anterior; Aphasia; Applications Grants; Area; Atrophic; Autopsy; Award; Beds; Behavioral Symptoms; Bilateral; Biological; Blood Tests; Brain; Brain Diseases; Brain imaging; Caregivers; Catechols; Categories; Cerebrospinal Fluid; Cessation of life; Chemicals; Chemistry; Clinical; Cognition; Cognitive; Cognitive deficits; Complete Blood Count; Complex; Comprehension; Consult; Country; Cross-Over Studies; Data; Dementia; Diagnosis; Disease; Disease Progression; Dopamine; Double-Blind Method; Dyskinetic syndrome; Effectiveness; Eligibility Determination; Enrollment; Ensure; Enzymes; Evaluation; Event; Exclusion Criteria; Experimental Designs; Family; Family Caregiver; Fingers; Frontotemporal Dementia; Functional Magnetic Resonance Imaging; Genetic; Genetic Polymorphism; Genetic Structures; Genetic screening method; Genotype; Goals; Grant; Grant Review; Health system; Healthcare Systems; Hepatotoxicity; Hospitals; Image; Impairment; Incidence; Institutional Review Boards; Internal Medicine; Intervention; Investigation; Judgment; Laboratories; Language; Language Tests; Lead; Life; Liver; Liver Function Tests; Magnetic Resonance Imaging; Measures; Memory Disorders; Methods; Minor; Monitor; Morbidity - disease rate; Names; National Institute of Neurological Disorders and Stroke; Neurobehavioral Manifestations; Neuropsychological Tests; Neurotransmitters; New York; Outcome; Outpatients; Participant; Patients; Performance; Persons; Pharmaceutical Preparations; Physicians; Placebo Control; Placebos; Plastics; Prefrontal Cortex; Procedures; Process; Productivity; Progressive Supranuclear Palsy; Protocols documentation; Psychotic Disorders; Reading; Recommendation; Recording of previous events; Reporting; Research; Research Design; Research Personnel; Research Project Grants; Role; Safety; Semantic Dementias; Serious Adverse Event; Services; Severities; Site; Social Behavior; Social Functioning; Societies; Specific qualifier value; Speech; Symptoms; Syndrome; System; Temporal Lobe; Testing; Therapeutic Intervention; Time; Transferase; Transferase Gene; Ultrasonography; United States; United States National Institutes of Health; Wisconsin; Work; abnormal involuntary movement; base; blood oxygen level dependent; design; disability; dopamine system; follow-up; follower of religion Jewish; frontal lobe function; improved; inhibitor/antagonist; innovation; meetings; member; mortality; north shore long island; research study; skills; social; tolcapone

项目成果

FUS and TDP43 genetic variability in FTD and CBS.

• DOI: 10.1016/j.neurobiolaging.2011.08.004
• 发表时间: 2012-05
• 期刊: Neurobiology of aging
• 影响因子: 4.2
• 作者: Huey ED;Ferrari R;Moreno JH;Jensen C;Morris CM;Potocnik F;Kalaria RN;Tierney M;Wassermann EM;Hardy J;Grafman J;Momeni P
• 通讯作者: Momeni P

Novel missense mutation in charged multivesicular body protein 2B in a patient with frontotemporal dementia.

• DOI: 10.1097/wad.0b013e3181df20c7
• 发表时间: 2010-10
• 期刊: Alzheimer disease and associated disorders
• 影响因子: 2.1
• 作者: Ferrari R;Kapogiannis D;Huey ED;Grafman J;Hardy J;Momeni P
• 通讯作者: Momeni P

Establishing dimensionality of sexual behaviours in patients with regional brain dysfunction.

建立区域脑功能障碍患者性行为的维度。

• DOI: 10.1080/02699052.2018.1497202
• 发表时间: 2018
• 期刊: Brain injury
• 影响因子: 1.9
• 作者: Fieo,RobertA;Silverman,Hannah;O'Shea,Deirdre;Manoochehri,Masood;Grafman,Jordan;Huey,EdwardD
• 通讯作者: Huey,EdwardD

Damage to the dorsolateral prefrontal cortex is associated with repetitive compulsive behaviors in patients with penetrating brain injury.

• DOI: 10.1136/bmjno-2021-000229
• 发表时间: 2022
• 期刊: BMJ NEUROLOGY OPEN
• 影响因子: 2.7
• 作者: Fremont, Rachel;Dworkin, Jordan;Manoochehri, Masood;Krueger, Frank;Huey, Edward;Grafman, Jordan
• 通讯作者: Grafman, Jordan

Neuropsychiatric effects of neurodegeneration of the medial versus lateral ventral prefrontal cortex in humans.

人类内侧腹侧前额叶皮质与外侧腹侧前额皮质神经变性的神经精神影响。

• DOI: 10.1016/j.cortex.2015.08.002
• 发表时间: 2015
• 期刊: Cortex; a journal devoted to the study of the nervous system and behavior
• 作者: Huey,EdwardD;Lee,Seonjoo;Brickman,AdamM;Manoochehri,Masood;Griffith,Erica;Devanand,DP;Stern,Yaakov;Grafman,Jordan
• 通讯作者: Grafman,Jordan