Effectiveness of Yoga on Ambulatory Blood Pressure in Patients with Pre- and Stag

瑜伽对前期和后期患者动态血压的影响

基本信息

批准号：
8327861
负责人：
MARSHALL A HAGINS
金额：
$ 10.48万
依托单位：
LONG ISLAND UNIVERSITY BROOKLYN CAMPUS
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-24 至 2013-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8327861
关键词：
Affect Agreement Area Awareness Biomechanics Blood Pressure Body mass index Complementary and alternative medicine Data Development Effectiveness Elements Exercise Expenditure Goals Health Health Benefit Heart Rate Heart failure Hour Human Hypertension Individual Interdisciplinary Study International Intervention Kidney Diseases Label Measurement Measures Meditation Metabolic Movement Myocardial Infarction Nature Outcome Participant Patients Peer Review Physical activity Physiological Physiology Posture Pressoreceptors Psychosocial Stress Publications Publishing Randomized Clinical Trials Relative (related person)Research Risk Factors Staging Stress and Coping Stroke Suggestion System Testing Training Uncertainty Work Yoga base blood pressure regulation clinically significant compare effectiveness expectation experience heart rate variability improved innovation programs psychologic psychosocial

项目摘要

DESCRIPTION (provided by applicant): Hypertension affects 50 million people in the US and is a significant risk factor for stroke, cardiac infarction, heart failure, and kidney disease. There is general evidence across multiple studies that yoga programs may be effective in the reduction of blood pressure. However, most of these studies are non-randomized and/or uncontrolled, examine healthy rather than hypertensive participants, and many use multi-modal "yoga-based" interventions in which it is impossible to determine the isolated effects of yoga. An additional substantive problem across these studies is the lack of agreement regarding what constitutes the intervention labeled "yoga." Consequently, there remains a need to clearly define a yoga intervention that represents common yoga practice and to determine the effects of such an intervention on blood pressure control. In western cultures, there is reasonable agreement that the most common yoga practice is defined by three integrated elements: physical postures, breath control, and meditation. Yoga adherents suggest that the integration of these elements produces greater health outcomes than would be expected through the simple addition of the independent effects of these elements. However, this suggestion has received no study. There is evidence that the yoga elements of breath control and meditation have clinically significant independent effects on blood pressure, while there is no evidence demonstrating that the physical postures (asana) of yoga have independent effects on blood pressure. The objectives of this application are to define standardized elements of an integrated yoga practice and determine the effects of the integrated practice compared to a single element of the practice (physical postures) on ambulatory blood pressure (ABP). The central hypothesis is that the integration of the elements of yoga (physical postures/breath control/meditation) will produce greater reductions in ABP than are produced through a single element of that practice (physical postures). We plan to test our thesis by performing a 12 week, RCT of 90 pre- and Stage I hypertensive participants. We will also examine a variety of secondary psychosocial and physiological measures related to the autonomic system: heart rate, heart rate variability, baroreceptor sensitivity, perceived stress, coping, tolerance of uncertainty, sense of control, and body mass index, which we expect to be correlated to improvements in ABP. The study will also determine the recruitment, retention, compliance, expectations, acceptance, and perceived effectiveness relative to the interventions. The information gained in this study will have a positive impact by providing critical preliminary and feasibility data to support a larger multi-ethnic RCT on the effects of yoga on individuals with Stage I hypertension.

描述（由申请人提供）：高血压在美国影响5000万人，是中风，心脏梗塞，心力衰竭和肾脏疾病的重要危险因素。在多项研究中有一般证据表明瑜伽计划可能有效地降低了血压。但是，这些研究中的大多数是非随机和/或不受控制的，检查健康而不是高血压参与者，并且许多研究使用了多模式的“基于瑜伽”的干预措施，在这些干预措施中无法确定瑜伽的孤立作用。在这些研究中，另一个实质性问题是关于构成标记为“瑜伽”的干预措施的一致性。因此，仍然需要明确定义代表常见瑜伽练习的瑜伽干预，并确定这种干预对血压控制的影响。在西方文化中，有合理的同意是，最常见的瑜伽实践是由三个综合元素定义的：身体姿势，呼吸控制和冥想。瑜伽信徒认为，这些元素的整合产生的健康结果比通过简单添加这些元素的独立效应所预期的更大。但是，该建议尚未获得研究。有证据表明，呼吸控制和冥想的瑜伽元素对血压具有临床上的显着独立影响，而没有证据表明瑜伽的物理姿势（体式）对血压具有独立的影响。本应用的目的是定义综合瑜伽实践的标准化元素，并确定综合实践的影响与实践（物理姿势）对卧床血压（ABP）相比。中心假设是，瑜伽元素（物理姿势/呼吸控制/冥想）的整合将比通过该实践的单个元素（物理姿势）产生的ABP降低。我们计划通过执行12周，RCT为90个前和I期高血压参与者来测试论文。我们还将研究与自主系统相关的多种二级心理社会和生理指标：心率，心率变异性，压力感受器敏感性，感知压力，应对，不确定性，控制意识和体重指数的耐受性，我们希望这与ABP中的改善相关。该研究还将确定相对于干预措施的募集，保留，合规性，期望，接受和感知的有效性。这项研究中获得的信息将通过提供关键的初步和可行性数据来产生积极的影响，以支持更大的多种族RCT对瑜伽对I期高血压患者的影响。