Molecular pathways that control differentiation and function of tissue-resident memory T cells

控制组织驻留记忆 T 细胞分化和功能的分子途径

• 批准号: nhmrc : GNT1147409
• 负责人: Dr Laura Mackay
• 金额: $ 87.83万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-pathways-control-t-cells/1348821
• 关键词: Molecular; pathways; control; differentiation; function

T cells residing in organs such as gut, liver or skin guard against infection and are critical for preventing tumour development. We found that the combined activities of two factors, Blimp1 and Hobit, are critical for the development of these so-called tissue-resident T cells. Using a series of new tools, we will identify how the molecular network required for the development of tissue-resident T cell is established. This may allow us to harness their critical functions in therapy.

肠道、肝脏或皮肤等器官中的 T 细胞可以防止感染，对于预防肿瘤的发展至关重要。我们发现，Blimp1 和 Hobit 这两个因子的联合活性对于这些所谓的组织驻留 T 细胞的发育至关重要。使用一系列新工具，我们将确定如何建立组织驻留 T 细胞发育所需的分子网络。这可能使我们能够在治疗中利用它们的关键功能。