课题基金 / 基金详情

NOVEL RECOMBINANT ADENOVIRUS VACCINE VECTORS FOR HIV/SIV IN RHESUS MONKEYS

NOVEL RECOMBINANT ADENOVIRUS VACCINE VECTORS FOR HIV/SIV IN RHESUS MONKEYS
用于恒河猴 HIV/SIV 的新型重组腺病毒疫苗载体
批准号：
7958318
负责人：
Dan H. Barouch
金额：
$11.19万
依托单位：
HARVARD MEDICAL SCHOOL
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
项目状态：
已结题
起止时间：
2009-05-01 至 2010-04-30
来源：
https://reporter.nih.gov/project-details/7958318
关键词：
AdenovirusesComputer Retrieval of Information on Scientific Projects DatabaseFrequenciesFundingGrantHIV-1 vaccineImmunityInstitutionMacaca mulattaNew EnglandPrimatesRecombinantsResearchResearch PersonnelResourcesSafetySerotypingSourceUnited States National Institutes of HealthVirusbaseimmunogenicitynovelvectorvector vaccinevector-based vaccine

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英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The high frequency of pre-existing immunity to the Ad5 vector has been shown to suppress the immunogenicity and possibly impair the safety of rAd5 vaccines for HIV-1. To overcome this hurdle, we have developed novel replication-incompetent rAd vector-based vaccines derived from rare Ad serotypes and chimeric viruses.
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NHP Core
Multi-Omics Analysis of Broadly Neutralizing Antibodies and Therapeutic Vaccination
Administrative Core
Multi-Omics Correlates of Broadly Neutralizing Antibody Efficacy