RENAL TRANSPLANTATION GRAFT SURVIVAL

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目的：探讨预防肾移植排斥反应的方法，提高肾移植患者的长期生存率。 我们评估了在细胞因子存在下培养的供体来源的单核细胞（Md细胞）是否能够诱导恒河猴对同种异体肾移植的供体特异性耐受。 细胞在移植前或移植后约一周输注。 我们还研究了标准免疫抑制剂对T细胞耗竭后T细胞亚群恢复的影响。 这项研究使用WNPRC动物服务。 在本报告期之前，该项目的资金已随PI转移至埃默里大学;但是，我们将该项目纳入本报告中，因为威斯康星州的工作产生了一份出版物。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To improve long-term survival in kidney transplant patients by discovering better ways to prevent organ rejection. We evaluated whether donor-derived monocytes (Md cells) cultured in the presence of cytokines are capable of inducing donor-specific tolerance to renal allografts in rhesus macaques. The cells are infused approximately one week pre- or post-transplant. We also studied the effects standard immunosuppressive agents on the recovery of T cell subsets following T-cell depletion. This research used WNPRC Animal Services. Funding for this project was transferred with the PI to Emory University before this reporting period; however, we are including this project in this report because a publication resulted from the Wisconsin work.