RENAL TRANSPLANTATION GRAFT SURVIVAL

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 通过发现更好的预防器官排斥反应的方法来提高肾移植患者的长期存活率。 我们正在评估在细胞因子存在下培养的供者来源的单核细胞(MD细胞)是否能够诱导恒河猴对同种异体肾移植的供者特异性耐受。这些细胞在移植前或移植后大约一周内被注入。 我们还在研究标准免疫抑制剂对T细胞耗尽后T细胞亚群恢复的影响。 这项研究使用了WNPRC动物服务中心。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To improve long-term survival in kidney transplant patients by discovering better ways to prevent organ rejection. We are evaluating whether donor-derived monocytes (Md cells) cultured in the presence of cytokines are capable of inducing donor-specific tolerance to renal allografts in rhesus macaques. The cells are infused approximately one week pre- or post-transplant. We are also studying the effects standard immunosuppressive agents on the recovery of T cell subsets following T-cell depletion. This research used WNPRC Animal Services.