RNAI-BASED GENE SILENCING IN NONHUMAN PRIMATES

非人类灵长类动物中基于 RNAI 的基因沉默

• 批准号: 7958379
• 负责人: Wei-Dong Yao
• 金额: $ 1.27万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958379
• 关键词: Cells; Computer Retrieval of Information on Scientific Projects Database; Funding; Gene Silencing; Goals; Grant; Institution; Macaca mulatta; Mediating; Mitotic; Neurobiology; Neurons; New England; Pilot Projects; Primates; Process; Proteins; RNA Interference; Research; Research Personnel; Resources; Source; System; United States National Institutes of Health; Viral; base; nervous system disorder; nonhuman primate; therapeutic development

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. RNA interference (RNAi) is an evolutionarily conserved process of sequence-specific post-transcriptional gene silencing. Viral-mediated RNAi allows rapid knockdown of endogenous proteins in post-mitotic cells, including neurons and has great potential in facilitating understanding the neurobiological basis of and therapeutic development against many psychiatric and neurological disorders. The goal of this pilot project is to develop a RNAi-based gene silencing system in rhesus macaque.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 RNA干扰(RNAi)是一种进化保守的序列特异性转录后基因沉默过程。病毒介导的RNAi可以快速敲除包括神经元在内的有丝分裂后细胞中的内源性蛋白质，在促进了解许多精神和神经疾病的神经生物学基础和治疗进展方面具有巨大的潜力。这个试点项目的目标是开发一种基于RNAi的恒河猴基因沉默系统。