NIDCD Core for Clinical Research and Care

NIDCD 临床研究和护理核心

• 批准号: 7970221
• 负责人: CARTER VAN WAES
• 金额: $ 107.04万
• 依托单位: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7970221
• 关键词: Administrator; Admission activity; Affect; Allegra; Ambulatory Care Facilities; Antigens; Appointment; Area; Asorbicap; Attention; Audiology; Auditory; Blood; Book Chapters; Brain imaging; Care given by nurses; Caring; Cetuximab; Chromosome Mapping; Cisplatin; Clinical; Clinical Investigator; Clinical Oncology; Clinical Research; Clinical Research Protocols; Clinical Services; Clinical Trials; Clinics and Hospitals; Communication; Communication impairment; Complex; Consult; Consultations; Continuing Education; Credentialing; Data; Data Collection; Databases; Development; Developmental Stuttering; Disease; Dopamine; Dyskeratosis Congenita; Educational workshop; Emergency Situation; Endoscopy; Equilibrium; Equipment and Supplies; Evaluation; Fellowship; Fostering; Functional Magnetic Resonance Imaging; Genes; Genetic; Genomics; Head and Neck Cancer; Head and Neck Surgeon; Head and Neck Surgery; Head and neck structure; Hearing; Hearing problem; Hematopoietic Neoplasms; Hereditary Disease; Hospitals; Hour; Human; Human Resources; India; Inherited; Inpatients; Institutes; Intramural Research Program; Laboratories; Language; Maintenance; Manuscripts; Measures; Mediating; Medical; Medical Students; Mentors; Metastatic Squamous Cell Carcinoma; Mission; Modeling; Molecular; Molecular Analysis; Monitor; Mus; NF-kappa B; National Institute on Deafness and Other Communication Disorders; Normal tissue morphology; Nursing Research; Operative Surgical Procedures; Otolaryngologist; Otolaryngology; Outcome; Outpatients; Paclitaxel; Pakistan; Pathogenesis; Patient Care; Patients; Phase I Clinical Trials; Philadelphia; Physicians; Policies; Positron-Emission Tomography; Process; Proteomics; Protocols documentation; Provider; Raclopride; Radiation; Radiation therapy; Recording of previous events; Records; Recovery; Recurrence; Research; Research Ethics Committees; Research Support; Resources; Screening procedure; Services; Signal Transduction; Sleep; Sleep Deprivation; Speech; Stuttering; Supervision; T-Cell Receptor; Taste Perception; Testing; Time; Tinnitus; Toxic effect; Travel; Triage; Trimethoprim-Sulfamethoxazole; United States National Institutes of Health; Vestibular Aqueduct; Visit; Voice; Yang; cancer regression; citrin; cognitive function; data management; deafness; gene therapy; genetic analysis; handbook; hearing impairment; human subject; inhibitor/antagonist; inpatient service; language processing; meetings; motor control; neoplasm therapy; neural model; neuroimaging; programs; protocol development; quality assurance; response; symposium; transcription factor; volunteer

The NIDCD Core for Clinical Research and Care supported the following NIDCD projects: 1 Z01-DC-000016-16 NF-kappaB in the molecular pathogenesis and therapy of Neoplasms Affecting Human Communication 1 Z01 DC000031-15 Functional Neuroimaging Studies in Humans 1 Z01 DC000039-13 Identification of Genes Causing Syndromic And Nonsyndromic Hearing Impairment 1 Z01 DC000046-12 Genetic Studies of Human Communications Disorders 1 Z01 DC000057-11 Brain Imaging And Modeling 1 Z01 DC000060-09 Molecular Analysis Of Human Hereditary Deafness 1 Z01 DC000064-09 Clinical Analysis Of Disorders Of Hearing And Balance 1 Z01-DC-000073-2 Signal and Transcription Factor Network Interactions in Head and Neck Cancer 1 Z01-DC-000074-2 Genomics and Proteomics of Head and Neck Cancer The NIDCD protocols supported by the core include: T-DC-0005 Studies of Measures of Attention Oh93-DC-0016 - Nonsyndromic Hereditary Hearing Impairment Gene Mapping: India / Pakistan Protocol 92-DC-0178 - Functional Neuroimaging Studies of Speech Motor Control and Language Processing 97-DC-0057 - Non-parametric and parametric Linkage Studies of Stuttering 97-DC-0180 - Genetic Analysis of Human Hereditary Hearing Impairment 00-DC-0073- Identification of Hereditary Auditory Processing Defiicts 00-DC-0176 - Genetic Studies of Tune Deafness 01-DC-0099 - Evaluation for NIDCD Head and Neck Surgery Branch Clinical Research Protocols 01-C-0104 - A Phase I Study of Concomitant Therapy with Preoteasome Inhibitor PS-341 and Radiation in Patients with Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck. 01-DC-0228 - Clinical and Molecular Analysis of Hearing Impairment Associated with Enlarged Vestibular Aqueducts (EVA) 01-DC-0229- Genetic Analysis of Hereditary Disorders of Hearing and Balance 01-DC-0230 - Studies in the Deficits in the Sense of Taste 02-DC-0008 - Assessment of pre- and post-synaptic dopamine function in developmental stuttering using C-11 raclopride and PET 05-DC-0238 - Effects of Sleep Deprivation and Recovery Sleep on Speech, Language and Other Higher Cognitive Functions: A Combined EEG-fMRI Study 06-DC-0218 - Neural Modeling and Brain Imaging of Tinnitus 08-C-0071 - Phase I Study of Bortezmib and Cetuximab without or with Cisplatin with Radiation therapy for Patients with Advanced Head and Neck Cancer The NIDCD Core for Clinical Research and Care in FY08 supported over 5,000 outpatient clinic evaluations, a 50% increase over the prior year. Core otolaryngologists performed over 100 major surgical cases. Staff mentored medical students during senior clinical clerkships.Collaborative studies resulted in contributions to several manuscripts and book chapters. Citrin D, Mansuetti J, Likhacheva A, Sciuto L, Albert PS, Rudy SF, Cooley-Zgela T, Cotrim A, Solomon B, Colevas AD, Russo A, Morris JC, Herscher L, Smith S, Van Waes C. Long-term outcomes and toxicity of concurrent paclitaxel and radiation in the treatment of locally advanced head and neck cancer, Int J Rad Oncol Biol Phys, 2009;74:1040-6. Savage SA, Dokal I, Armanios M, Aubert G, Cowen EW, Domingo DL, Giri N, Orchard PJ, Tolar J, Tsilou E, Van Waes C, Wong JMY, Young NS, Alter BP. Dyskeratosis congenita: The first NIH clinical research workshop. Ped Blood & Cancer, 2009; 2009;53:520-3 Johnson LA, Morgan RA, Dudley ME, Cassard L, Yang JC, Hughes MS, Kammula US, Royal RE, Sherry RM, Wunderlich JR, Lee CR, Restifo NP, Schwarz SL, Cogdil AP, Bishop RJ, Kim HJ, Brewer CC, Rudy SF, Van Waes C, Davis JL, Mathur A, Ripley RT, Nathan DA, Laurencot CM, Rosenberg SA. Gene therapy with human and mouse T cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen. Blood, 2009, in press 2009;114:535-46. Estrada DT, Van Waes C, Moni J, Conley BA. Head and Neck Cancer. In, Abraham J, Gulley JL, Allegra CJ, Ed. The Bethesda Handbook of Clinical Oncology, Wolters Kluwer/Lippincott Williams and Wilkins, Philadelphia, 2010, 3-34

NIDCD临床研究和护理核心支持以下NIDCD项目： 1 Z 01-DC-000016-16 NF-kappaB在影响人类交流的神经系统疾病的分子发病机制和治疗中的作用 1 Z 01 DC 000031 -15人体功能性神经影像学研究 1 Z 01 DC 000039 -13综合征型和非综合征型听力损伤基因的鉴定 1 Z 01 DC 000046 -12人类交流障碍的遗传学研究 1 Z 01 DC 000057 -11脑成像和建模 1 Z 01 DC 000060 -09人类遗传性耳聋的分子分析 1 Z 01 DC 000064 -09听力和平衡障碍的临床分析 1 Z 01-DC-000073-2头颈癌中信号和转录因子网络的相互作用 1 Z 01-DC-000074-2头颈癌的基因组学和蛋白质组学 核心支持的NIDCD协议包括： T-DC-0005注意力测量研究 Oh 93-DC-0016 -非综合征型遗传性听力障碍基因定位：印度/巴基斯坦方案 92-DC-0178 -言语运动控制和语言处理的功能性神经成像研究 97-DC-0057 -口吃的非参数和参数连锁研究 97-DC-0180 -人类遗传性听力障碍的遗传分析 00-DC-0073-遗传性听觉处理缺陷的识别 00-DC-0176 -音调性耳聋的遗传学研究 01-DC-0099 -NIDCD头颈外科分支临床研究方案评价 01-C-0104 -一项在复发性或转移性头颈部鳞状细胞癌患者中进行的前体蛋白酶体抑制剂PS-341和放疗联合治疗的I期研究。 01-DC-0228 -前庭水管扩大（伊娃）相关听力损伤的临床和分子分析 01-DC-0229-遗传性听力和平衡障碍的遗传分析 01-DC-0230 -味觉缺陷的研究 02-DC-0008 -使用C-11雷氯必利和PET评估发育性口吃中突触前和突触后多巴胺功能 05-DC-0238 -睡眠延迟和恢复睡眠对言语、语言和其他高级认知功能的影响：一项联合EEG和fMRI研究 06-DC-0218 -Tintin的神经建模和脑成像 08-C-0071 -硼替佐米和西妥昔单抗联合或不联合顺铂放疗治疗晚期头颈癌患者的I期研究 2008财年，NIDCD临床研究和护理核心支持了5,000多项门诊评估，比上一年增加了50%。核心耳鼻喉科医生完成了100多例重大手术病例。在高级临床实习期间，工作人员指导医学生。合作研究为几份手稿和书籍章节做出了贡献。 Citrin D，Mansuetti J，Likhacheva A，Sciuto L，Albert PS，Rudy SF，Cooley-Zgela T，Cotrim A，所罗所罗门B，Colevas AD，Russo A，Morris JC，Herscher L，Smith S，货车Waes C. 紫杉醇联合放疗治疗局部晚期头颈癌的长期结局和毒性，Int J Rad Oncol Biol Phys，2009;74：1040-6。 Savage SA，Dokal I，Armanios M，Aubert G，Cowen EW，Domingo DL，Giri N，果园PJ，Tolar J，Tsilou E，货货车Waes C，Wong JMY，Young NS，Alter BP.先天性角化不良：第一个NIH临床研究研讨会。儿科血液与癌症，2009; 2009;53：520-3 约翰逊LA，摩根RA，达德利ME，Cassard L，杨JC，休斯MS，Kammula US，皇家RE，雪莉RM，Wunderlich JR，李CR，Restifo NP，施瓦茨SL，Cogdil AP，RJ Bishop，金HJ，布鲁尔CC，鲁迪SF，货车Waes C，戴维斯JL，马瑟A，里普利RT，内森DA，劳伦科特CM，罗森伯格SA.人类和小鼠T细胞受体的基因治疗介导癌症消退并靶向表达同源抗原的正常组织。Blood，2009，in press 2009;114：535-46. Estrada DT，货车Waes C，Moni J，Conley BA.头颈癌In，Abraham J，Gulley JL，Allegra CJ，Ed. The Bethesda Handbook of Clinical Oncology，Wolters Kluwer/Lippincott威廉姆斯和威尔金斯，费城，2010，3-34