NIDCD Core for Clinical Research and Care

NIDCD临床研究和护理核心支持了以下NIDCD项目： 1 Z01-DC-000016-16核因子-kappaB在影响人类沟通的肿瘤分子发病机制和治疗中的作用 1 Z01 DC000031-15人体神经功能成像研究 1 Z01 DC000039-13导致综合征性和非综合征性听力障碍的基因鉴定 1 Z01 DC000046-12人类通讯障碍的遗传学研究 1 Z01 DC000057-11脑成像与建模 1 Z01 DC000060-09遗传性耳聋的分子分析 1 Z01 DC000064-09听力平衡障碍临床分析 1 Z01-DC-000073-2信号与转录因子网络在头颈癌中的相互作用 1头颈癌Z01-DC-000074-2基因组学和蛋白质组学研究 核心支持的NIDCD协议包括： T-DC-0005注意力测量方法的研究 Oh93-DC-0016-非综合征遗传性耳聋基因图谱：印度/巴基斯坦方案 92-DC-0178-言语运动控制和语言处理的功能神经成像研究 97-DC-0057-口吃的非参数和参数链接研究 97-DC-0180-遗传性耳聋的遗传分析 00-DC-0073-遗传性听觉处理缺陷的鉴定 00-DC-0176-调音性耳聋的遗传学研究 01-DC-0099-NIDCD头颈外科分会临床研究方案评价 01-C-0104-头颈部复发性或转移性鳞癌患者联合应用茶酶前体抑制剂PS-341和放射治疗的I期研究。 01-DC-0228-前庭导水管扩大所致听力损害的临床和分子分析 01-DC-0229-遗传性听力和平衡障碍的遗传分析 01-DC-0230-味觉缺陷研究 02-DC-0008-使用C-11雷氯普利和PET评估发育性口吃突触前和突触后的多巴胺功能 05-DC-0238-睡眠剥夺和恢复睡眠对言语、语言和其他高级认知功能的影响：一项脑电-功能磁共振联合研究 06-DC-0218-耳鸣的神经模型和脑成像 08-C-0071-波特兹米布和西妥昔单抗联合或联合顺铂治疗晚期头颈癌的I期研究 NIDCD临床研究和护理核心在2008财年支持了5,000多项门诊评估，比前一年增加了50%。耳鼻咽喉科核心医生进行了100多例大手术。在高级临床助理期间，工作人员指导医学生。合作研究导致了几篇手稿和书籍章节的贡献。 Citrin D，Mansuetti J，Likhacheva A，Sciuto L，Albert PS，Rudy SF，Cooley-Zgela T，Cotrim A，所罗门B，Colevas AD，Russo A，Morris JC，Herscher L，Smith S，Van Waes C。紫杉醇和放射治疗局部晚期头颈癌的长期疗效和毒性，Int J Rad Onol Biol Phys，2009；74：1040-6。 Savage SA，Dokal I，Armanios M，Aubert G，Cowen EW，Domingo DL，Giri N，Orchard PJ，Tole J，Tsilou E，Van Waes C，Wong JMY，Young NS，Alter BP。先天性角化不良：美国国立卫生研究院首届临床研究研讨会。PED血液与癌症，2009年；2009年；53：520-3 约翰逊LA、摩根RA、达德利·ME、卡萨德·L、杨JC、休斯·MS、卡姆拉美国、皇家RE、雪莉·RM、Wunderlich Jr、Lee CR、Rstifo NP、Schwarz SL、Cogdil AP、Bishop RJ、Kim HJ、布鲁尔CC、Rudy SF、Van Waes C、Davis JL、Mathur A、Ripley RT、Nathan DA、Laurencot CM、Rosenberg SA。人类和小鼠T细胞受体的基因治疗介导癌症的消退，并以表达同源抗原的正常组织为靶点。《血色》，2009年出版；114：-46。 Estrada DT，Van Waes C，Moni J，Conley BA。头颈癌。见，Abraham J，Gulley JL，Allegra CJ，Ed.《贝塞斯达临床肿瘤学手册》，沃尔特斯·克鲁沃/利平科特·威廉姆斯和威尔金斯，费城，2010，3-34

The NIDCD Core for Clinical Research and Care supported the following NIDCD projects: 1 Z01-DC-000016-16 NF-kappaB in the molecular pathogenesis and therapy of Neoplasms Affecting Human Communication 1 Z01 DC000031-15 Functional Neuroimaging Studies in Humans 1 Z01 DC000039-13 Identification of Genes Causing Syndromic And Nonsyndromic Hearing Impairment 1 Z01 DC000046-12 Genetic Studies of Human Communications Disorders 1 Z01 DC000057-11 Brain Imaging And Modeling 1 Z01 DC000060-09 Molecular Analysis Of Human Hereditary Deafness 1 Z01 DC000064-09 Clinical Analysis Of Disorders Of Hearing And Balance 1 Z01-DC-000073-2 Signal and Transcription Factor Network Interactions in Head and Neck Cancer 1 Z01-DC-000074-2 Genomics and Proteomics of Head and Neck Cancer The NIDCD protocols supported by the core include: T-DC-0005 Studies of Measures of Attention Oh93-DC-0016 - Nonsyndromic Hereditary Hearing Impairment Gene Mapping: India / Pakistan Protocol 92-DC-0178 - Functional Neuroimaging Studies of Speech Motor Control and Language Processing 97-DC-0057 - Non-parametric and parametric Linkage Studies of Stuttering 97-DC-0180 - Genetic Analysis of Human Hereditary Hearing Impairment 00-DC-0073- Identification of Hereditary Auditory Processing Defiicts 00-DC-0176 - Genetic Studies of Tune Deafness 01-DC-0099 - Evaluation for NIDCD Head and Neck Surgery Branch Clinical Research Protocols 01-C-0104 - A Phase I Study of Concomitant Therapy with Preoteasome Inhibitor PS-341 and Radiation in Patients with Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck. 01-DC-0228 - Clinical and Molecular Analysis of Hearing Impairment Associated with Enlarged Vestibular Aqueducts (EVA) 01-DC-0229- Genetic Analysis of Hereditary Disorders of Hearing and Balance 01-DC-0230 - Studies in the Deficits in the Sense of Taste 02-DC-0008 - Assessment of pre- and post-synaptic dopamine function in developmental stuttering using C-11 raclopride and PET 05-DC-0238 - Effects of Sleep Deprivation and Recovery Sleep on Speech, Language and Other Higher Cognitive Functions: A Combined EEG-fMRI Study 06-DC-0218 - Neural Modeling and Brain Imaging of Tinnitus 08-C-0071 - Phase I Study of Bortezmib and Cetuximab without or with Cisplatin with Radiation therapy for Patients with Advanced Head and Neck Cancer The NIDCD Core for Clinical Research and Care in FY08 supported over 5,000 outpatient clinic evaluations, a 50% increase over the prior year. Core otolaryngologists performed over 100 major surgical cases. Staff mentored medical students during senior clinical clerkships.Collaborative studies resulted in contributions to several manuscripts and book chapters. Citrin D, Mansuetti J, Likhacheva A, Sciuto L, Albert PS, Rudy SF, Cooley-Zgela T, Cotrim A, Solomon B, Colevas AD, Russo A, Morris JC, Herscher L, Smith S, Van Waes C. Long-term outcomes and toxicity of concurrent paclitaxel and radiation in the treatment of locally advanced head and neck cancer, Int J Rad Oncol Biol Phys, 2009;74:1040-6. Savage SA, Dokal I, Armanios M, Aubert G, Cowen EW, Domingo DL, Giri N, Orchard PJ, Tolar J, Tsilou E, Van Waes C, Wong JMY, Young NS, Alter BP. Dyskeratosis congenita: The first NIH clinical research workshop. Ped Blood & Cancer, 2009; 2009;53:520-3 Johnson LA, Morgan RA, Dudley ME, Cassard L, Yang JC, Hughes MS, Kammula US, Royal RE, Sherry RM, Wunderlich JR, Lee CR, Restifo NP, Schwarz SL, Cogdil AP, Bishop RJ, Kim HJ, Brewer CC, Rudy SF, Van Waes C, Davis JL, Mathur A, Ripley RT, Nathan DA, Laurencot CM, Rosenberg SA. Gene therapy with human and mouse T cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen. Blood, 2009, in press 2009;114:535-46. Estrada DT, Van Waes C, Moni J, Conley BA. Head and Neck Cancer. In, Abraham J, Gulley JL, Allegra CJ, Ed. The Bethesda Handbook of Clinical Oncology, Wolters Kluwer/Lippincott Williams and Wilkins, Philadelphia, 2010, 3-34