Multicenter AIDS Cohort Study

多中心艾滋病队列研究

• 批准号: 8145356
• 负责人: CHARLES R RINALDO
• 金额: $ 41.55万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2012-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8145356
• 关键词: AIDS/HIV problem; Accounting; Acquired Immunodeficiency Syndrome; Adherence; Adverse effects; Affect; Age; Alcohol or Other Drugs use; Anti-Retroviral Agents; Behavioral; Biological; Cardiovascular Diseases; Cardiovascular system; Clinical; Cohort Studies; Combined Modality Therapy; Companions; Competence; Data; Diabetes Mellitus; Disease; Disease Progression; Dyslipidemias; Epidemiology; Exposure to; Genetic; Glucose; HIV; HIV Infections; HIV drug resistance; HIV therapy; Health; Hepatitis B Virus; Hepatitis C virus; Highly Active Antiretroviral Therapy; Human immunodeficiency virus test; Immune; Immunotherapeutic agent; Incidence; Individual; Infection; Insulin; Intervention; Investigation; Kidney Diseases; Knowledge; Laboratories; Lipids; Lipodystrophy; Liver Function Tests; Liver diseases; Long-Term Effects; Longitudinal Studies; Maintenance; Malignant Neoplasms; Mission; Natural History; Neoplasms; Neurocognitive; Outcome; Participant; Pathogenesis; Pattern; Population; Public Health; Recording of previous events; Recruitment Activity; Regimen; Renal function; Research; Risk Behaviors; Risk Factors; Serum; Specimen; Substance abuse problem; T-Lymphocyte Subsets; Testing; Therapeutic; Treatment Effectiveness; U-Series Cooperative Agreements; United States National Institutes of Health; Vaccines; Viral Load result; age effect; antiretroviral therapy; cohort; follow-up; improved; insight; men; men who have sex with men; physical process; prevent; programs; prophylactic; psychologic; repository; response; therapy development; transmission process

DESCRIPTION (provided by applicant): This application is Part B of a competing renewal to the Pittsburgh component of the Multicenter AIDS Cohort Study (MACS) Cooperative Agreement (1 U01 AI035041), the companion to the Part A composite application that is being submitted by CAMACS. The MACS began in 1983 as a longitudinal study of the natural history of AIDS in men who have sex with men (MSM). This request is for an additional five years of support for clinical follow-up and laboratory testing of the cohort of MSM in the Pittsburgh MACS. The broad objectives of the Pittsburgh MACS are to fulfill the specific aims of the Part A master MACS application, and do special studies locally in Pittsburgh to enhance our epidemiologic and pathogenesis knowledge in relation to treatment intervention, and development of immunotherapeutic and prophylactic vaccines. Our specific aims are to determine the long-term natural and treated history of HIV infection in MSM, characterize the responses to HIV therapy, including psychological and behavioral predictors, examine the effects of HIV and prolonged HIV therapy exposure on lipodystrophy, diabetes, cardiovascular disease, liver disease, malignancies, neurocognitive function, substance use, kidney disease, and other outcomes, assess the effects of aging on the clinical course of HIV and HIV therapy, examine the interaction between host genetics and HIV, define HIV pathogenesis, characterize HIV-associated cancers including identification of risk factors, determine socio-behavioral factors that affect HIV transmission and disease progression, characterize concomitant infections and their effects on HIV disease progression, examine the effects of substance abuse on antiretroviral treatment effectiveness, maintain longitudinally collected epidemiological data and biological specimen repository as a platform to facilitate natural history and pathogenesis studies, perform clinical and lab testing of MSM in the Pittsburgh MACS, including T-cell subsets, anti-HIV Ab, HIV viral load, hepatitis B virus and hepatitis C virus testing, serum lipid/insulin/glucose levels, liver function tests, renal function and cardiovascular studies. This research has direct relevance to the mission of the NIH to cure and prevent HIV infection and AIDS. RELEVANCE: As part of the MACS research consortium, the Pittsburgh MACS proposes to continue its 25 year scientific investigation into the natural history of HIV/AIDS. This research provides insight into the mechanisms of HIV infection, the effects of HIV therapy, and development of therapeutic and preventative vaccines for HIV infection. It is highly relevant to HIV/AIDS public health programs of the NIH.

描述（由申请人提供）： 该应用是对多中心艾滋病队列研究（MACS）合作协议（1 U01 AI035041）的匹兹堡组成部分的竞争续约的B部分，这是Camacs提交的综合应用程序的伴侣。 Mac始于1983年，是对与男性发生性关系（MSM）的男性自然历史的纵向研究。该请求是对匹兹堡MAC中MSM队列的临床随访和实验室测试的另外五年支持。匹兹堡MAC的广泛目标是实现MACS应用程序的特定目的，并在匹兹堡进行特殊研究，以增强我们在治疗干预方面的流行病学和发病机理知识，并开发免疫治疗和预防性疫苗。 Our specific aims are to determine the long-term natural and treated history of HIV infection in MSM, characterize the responses to HIV therapy, including psychological and behavioral predictors, examine the effects of HIV and prolonged HIV therapy exposure on lipodystrophy, diabetes, cardiovascular disease, liver disease, malignancies, neurocognitive function, substance use, kidney disease, and other outcomes, assess the effects of aging on the艾滋病毒和艾滋病毒治疗的临床过程，检查宿主遗传学与艾滋病毒之间的相互作用，定义艾滋病毒发病机理，表征与艾滋病毒相关的癌症的特征 epidemiological data and biological specimen repository as a platform to facilitate natural history and pathogenesis studies, perform clinical and lab testing of MSM in the Pittsburgh MACS, including T-cell subsets, anti-HIV Ab, HIV viral load, hepatitis B virus and hepatitis C virus testing, serum lipid/insulin/glucose levels, liver function tests, renal function and cardiovascular研究。这项研究直接与NIH的使命相关，以治愈和预防艾滋病毒感染和艾滋病。相关性：作为MACS研究联盟的一部分，匹兹堡Mac提议继续对艾滋病毒/艾滋病自然史进行25年的科学研究。这项研究提供了对HIV感染的机制，HIV治疗的作用以及对HIV感染的治疗和预防疫苗的开发。它与NIH的艾滋病毒/艾滋病公共卫生计划高度相关。