Multicenter AIDS Cohort Study

多中心艾滋病队列研究

• 批准号: 7926415
• 负责人: CHARLES R RINALDO
• 金额: $ 126万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-22 至 2012-09-21
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7926415
• 关键词: AIDS/HIV problem; Accounting; Acquired Immunodeficiency Syndrome; Adherence; Adverse effects; Affect; Age; Alcohol or Other Drugs use; Anti-Retroviral Agents; Behavioral; Biological; Cardiovascular Diseases; Cardiovascular system; Clinical; Cohort Studies; Combined Modality Therapy; Companions; Competence; Data; Diabetes Mellitus; Disease; Disease Progression; Dyslipidemias; Epidemiology; Exposure to; Genetic; Glucose; HIV; HIV Infections; HIV drug resistance; HIV therapy; Health; Hepatitis B Virus; Hepatitis C virus; Highly Active Antiretroviral Therapy; Human immunodeficiency virus test; Immune; Immunotherapeutic agent; Incidence; Individual; Infection; Instruction; Insulin; Intervention; Investigation; Kidney Diseases; Knowledge; Laboratories; Lipids; Lipodystrophy; Liver Function Tests; Liver diseases; Long-Term Effects; Longitudinal Studies; Maintenance; Malignant Neoplasms; Mission; Natural History; Neoplasms; Neurocognitive; Outcome; Participant; Pathogenesis; Pattern; Population; Public Health; Recording of previous events; Renal function; Research; Risk Behaviors; Risk Factors; Serum; Specimen; Substance abuse problem; T-Lymphocyte Subsets; Testing; Therapeutic; Treatment Effectiveness; Treatment Protocols; U-Series Cooperative Agreements; United States National Institutes of Health; Vaccines; Viral Load result; age effect; antiretroviral therapy; cohort; follow-up; improved; insight; men; men who have sex with men; physical process; prevent; programs; prophylactic; psychologic; repository; response; therapy development; transmission process

This application is Part B of a proposal for a competing renewal to the Pittsburgh component of the Multicenter AIDS Cohort Study (MACS) Cooperative Agreement (1UO1-AI-35041), the companion to the Part A composite proposal that is being submitted by CAMACS. The MACS began in 1983 as a longitudinal study of the natural history of AIDS in men who have sex with men (MSM). This request is for an additional five years of support for clinical follow-up and laboratory testing of the cohort of MSM in the Pittsburgh MACS. The broad objectives of the Pittsburgh MACS is to fulfill the specific aims of the Part A master MACS application, and do special studies locally in Pittsburgh to enhance our epidemiologic and pathogenesis knowledge in relation to treatment intervention, and development of immunotherapeutic and prophylactic vaccines. Our specific aims are to determine the long-term natural and treated history of HIV infection in MSM, characterize the responses to HIV therapy, including psychological and behavioral predictors, examine the effects of HIV and prolonged HIV therapy exposure on lipodystrophy, diabetes, cardiovascular disease, liver disease, malignancies, neurocognitive function, substance use, kidney disease, and other outcomes, assess the effects of aging on the clinical course of HIV and HIV therapy, examine the interaction between host genetics and HIV, define HIV pathogenesis, characterize HIV-associated cancers including identification of risk factors, determine socio-behavioral factors that affect HIV transmission and disease progression, characterize concomitant infections and their effects on HIV disease progression, examine the effects of substance abuse on antiretroviral treatment effectiveness, maintain longitudinally collected epidemiological data and biological specimen repository as a platform to facilitate natural history and pathogenesis studies, perform clinical and lab testing of MSM in the Pittsburgh MACS, including T cell subsets, anti-HIV Ab, HIV viral load, hepatitis B virus and hepatitis C virus testing, serum lipid/insulin/glucose levels, liver function tests, renal function and cardiovascular studies. This research has direct relevance to the mission of the NIH to cure and prevent HIV infection and AIDS. RELEVANCE (See instructions): As part of the MACS research consortium, the Pittsburgh MACS proposes to continue its 25 year scientific investigation into the natural history of HIV/AIDS. This research provides insight into the mechanisms of HIV infection, the effects of HIV therapy, and development of therapeutic and preventative vaccines for HIV infection. It is highly relevant to HIV/AIDS public health programs of the NIH.

该申请是向匹兹堡组成部分竞争续约的建议的B部分 多中心艾滋病队列研究（MACS）合作协议（1UO1-35041）， 一部分由Camacs提交的复合建议。 Mac始于1983年作为纵向 研究与男性发生性关系（MSM）的男性艾滋病的自然历史。此请求是附加的 匹兹堡MSM队列的临床随访和实验室测试的五年支持 Mac。匹兹堡Mac的广泛目标是实现大师Mac的特定目的 应用，并在匹兹堡本地进行特殊研究，以增强我们的流行病学和发病机理 与治疗干预以及免疫治疗和预防性的发展有关的知识 疫苗。我们的具体目的是确定艾滋病毒感染的长期自然和治疗史 MSM，表征对HIV疗法的反应，包括心理和行为预测指标， 检查HIV和长期HIV治疗对脂肪营养不良，糖尿病，心血管的影响 疾病，肝病，恶性肿瘤，神经认知功能，药物使用，肾脏疾病和其他 结果，评估衰老对HIV和HIV疗法临床过程的影响，检查相互作用 在宿主遗传学和HIV之间，定义HIV发病机理，表征与HIV相关的癌症，包括 识别危险因素，确定影响HIV传播和疾病的社会行为因素 进展，表征伴随感染及其对艾滋病毒疾病进展的影响，检查 药物滥用对抗逆转录病毒治疗有效性的影响，保持纵向收集 流行病学数据和生物标本存储库作为促进自然历史和的平台 发病机理研究，在匹兹堡MAC中对MSM进行临床和实验室测试，包括T细胞 子集，抗HIV AB，HIV病毒载量，乙型肝炎病毒和乙型肝炎病毒测试，血清脂质/胰岛素/葡萄糖 水平，肝功能测试，肾功能和心血管研究。这项研究与 NIH的使命是治愈和预防艾滋病毒感染和艾滋病。 相关性（请参阅说明）： 作为MACS研究协会的一部分，匹兹堡Mac提议继续其25年的科学 调查艾滋病毒/艾滋病的自然史。这项研究提供了对艾滋病毒机制的见解 感染，艾滋病毒治疗的作用以及艾滋病毒治疗和预防性疫苗的开发 感染。它与NIH的艾滋病毒/艾滋病公共卫生计划高度相关。