Multicenter AIDS Cohort Study

多中心艾滋病队列研究

• 批准号: 8066500
• 负责人: CHARLES R RINALDO
• 金额: $ 222.13万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8066500
• 关键词: AIDS/HIV problem; Accounting; Acquired Immunodeficiency Syndrome; Adherence; Adverse effects; Affect; Age; Alcohol or Other Drugs use; Anti-Retroviral Agents; Behavioral; Biological; Cardiovascular Diseases; Cardiovascular system; Clinical; Cohort Studies; Combined Modality Therapy; Companions; Competence; Data; Diabetes Mellitus; Disease; Disease Progression; Dyslipidemias; Epidemiology; Exposure to; Genetic; Glucose; HIV; HIV Infections; HIV drug resistance; HIV therapy; Health; Hepatitis B Virus; Hepatitis C virus; Highly Active Antiretroviral Therapy; Human immunodeficiency virus test; Immune; Immunotherapeutic agent; Incidence; Individual; Infection; Insulin; Intervention; Investigation; Kidney Diseases; Knowledge; Laboratories; Lipids; Lipodystrophy; Liver Function Tests; Liver diseases; Long-Term Effects; Longitudinal Studies; Maintenance; Malignant Neoplasms; Mission; Natural History; Neoplasms; Neurocognitive; Outcome; Participant; Pathogenesis; Pattern; Population; Public Health; Recording of previous events; Recruitment Activity; Regimen; Renal function; Research; Risk Behaviors; Risk Factors; Serum; Specimen; Substance abuse problem; T-Lymphocyte Subsets; Testing; Therapeutic; Treatment Effectiveness; U-Series Cooperative Agreements; United States National Institutes of Health; Vaccines; Viral Load result; age effect; antiretroviral therapy; cohort; follow-up; improved; insight; men; men who have sex with men; physical process; prevent; programs; prophylactic; psychologic; repository; response; therapy development; transmission process

DESCRIPTION (provided by applicant): This application is Part B of a competing renewal to the Pittsburgh component of the Multicenter AIDS Cohort Study (MACS) Cooperative Agreement (1 U01 AI035041), the companion to the Part A composite application that is being submitted by CAMACS. The MACS began in 1983 as a longitudinal study of the natural history of AIDS in men who have sex with men (MSM). This request is for an additional five years of support for clinical follow-up and laboratory testing of the cohort of MSM in the Pittsburgh MACS. The broad objectives of the Pittsburgh MACS are to fulfill the specific aims of the Part A master MACS application, and do special studies locally in Pittsburgh to enhance our epidemiologic and pathogenesis knowledge in relation to treatment intervention, and development of immunotherapeutic and prophylactic vaccines. Our specific aims are to determine the long-term natural and treated history of HIV infection in MSM, characterize the responses to HIV therapy, including psychological and behavioral predictors, examine the effects of HIV and prolonged HIV therapy exposure on lipodystrophy, diabetes, cardiovascular disease, liver disease, malignancies, neurocognitive function, substance use, kidney disease, and other outcomes, assess the effects of aging on the clinical course of HIV and HIV therapy, examine the interaction between host genetics and HIV, define HIV pathogenesis, characterize HIV-associated cancers including identification of risk factors, determine socio-behavioral factors that affect HIV transmission and disease progression, characterize concomitant infections and their effects on HIV disease progression, examine the effects of substance abuse on antiretroviral treatment effectiveness, maintain longitudinally collected epidemiological data and biological specimen repository as a platform to facilitate natural history and pathogenesis studies, perform clinical and lab testing of MSM in the Pittsburgh MACS, including T-cell subsets, anti-HIV Ab, HIV viral load, hepatitis B virus and hepatitis C virus testing, serum lipid/insulin/glucose levels, liver function tests, renal function and cardiovascular studies. This research has direct relevance to the mission of the NIH to cure and prevent HIV infection and AIDS. RELEVANCE: As part of the MACS research consortium, the Pittsburgh MACS proposes to continue its 25 year scientific investigation into the natural history of HIV/AIDS. This research provides insight into the mechanisms of HIV infection, the effects of HIV therapy, and development of therapeutic and preventative vaccines for HIV infection. It is highly relevant to HIV/AIDS public health programs of the NIH.

描述（由申请人提供）： 本申请是多中心艾滋病队列研究 (MACS) 合作协议 (1 U01 AI035041) 匹兹堡部分的竞争更新的 B 部分，该协议是 CAMACS 提交的 A 部分综合申请的配套文件。 MACS 始于 1983 年，是一项针对男男性行为者 (MSM) 艾滋病自然史的纵向研究。该请求是为匹兹堡 MACS 的 MSM 群体的临床随访和实验室测试提供额外五年的支持。匹兹堡 MACS 的总体目标是实现 A 部分主 MACS 应用程序的具体目标，并在匹兹堡当地进行专门研究，以增强我们与治疗干预以及免疫治疗和预防性疫苗开发相关的流行病学和发病机制知识。我们的具体目标是确定 MSM 中 HIV 感染的长期自然和治疗史，描述对 HIV 治疗的反应，包括心理和行为预测因素，检查 HIV 和长期 HIV 治疗暴露对脂肪营养不良、糖尿病、心血管疾病、肝脏疾病、恶性肿瘤、神经认知功能、物质使用、肾脏疾病和其他结果的影响，评估衰老对 HIV和HIV治疗的临床过程，检查宿主遗传学和HIV之间的相互作用，定义HIV发病机制，描述HIV相关癌症的特征，包括识别危险因素，确定影响HIV传播和疾病进展的社会行为因素，描述伴随感染及其对HIV疾病进展的影响，检查药物滥用对抗逆转录病毒治疗效果的影响，保持纵向收集 流行病学数据和生物标本存储库作为促进自然史和发病机制研究的平台，在匹兹堡 MACS 进行 MSM 的临床和实验室检测，包括 T 细胞亚群、抗 HIV 抗体、HIV 病毒载量、乙型肝炎病毒和丙型肝炎病毒检测、血脂/胰岛素/血糖水平、肝功能检测、肾功能和心血管 研究。这项研究与美国国立卫生研究院治愈和预防艾滋病毒感染和艾滋病的使命直接相关。相关性：作为 MACS 研究联盟的一部分，匹兹堡 MACS 提议继续对 HIV/AIDS 自然史进行 25 年的科学研究。这项研究深入了解了 HIV 感染的机制、HIV 治疗的效果以及 HIV 感染的治疗和预防疫苗的开发。它与 NIH 的艾滋病毒/艾滋病公共卫生计划高度相关。