Multicenter AIDS Cohort Study
多中心艾滋病队列研究
基本信息
- 批准号:7926541
- 负责人:
- 金额:$ 59.12万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-09-22 至 2012-09-21
- 项目状态:已结题
- 来源:
- 关键词:AIDS/HIV problemAccountingAcquired Immunodeficiency SyndromeAdherenceAdverse effectsAffectAgeAlcohol or Other Drugs useAnti-Retroviral AgentsBehavioralBiologicalCardiovascular DiseasesCardiovascular systemClinicalCohort StudiesCombined Modality TherapyCompanionsCompetenceDataDiabetes MellitusDiseaseDisease ProgressionDyslipidemiasEpidemiologyExposure toGeneticGlucoseHIVHIV InfectionsHIV drug resistanceHIV therapyHealthHepatitis B VirusHepatitis C virusHighly Active Antiretroviral TherapyHuman immunodeficiency virus testImmuneImmunotherapeutic agentIncidenceIndividualInfectionInstructionInsulinInterventionInvestigationKidney DiseasesKnowledgeLaboratoriesLipidsLipodystrophyLiver Function TestsLiver diseasesLong-Term EffectsLongitudinal StudiesMaintenanceMalignant NeoplasmsMissionNatural HistoryNeoplasmsNeurocognitiveOutcomeParticipantPathogenesisPatternPopulationPublic HealthRecording of previous eventsRenal functionResearchRisk BehaviorsRisk FactorsSerumSpecimenSubstance abuse problemT-Lymphocyte SubsetsTestingTherapeuticTreatment EffectivenessTreatment ProtocolsU-Series Cooperative AgreementsUnited States National Institutes of HealthVaccinesViral Load resultage effectantiretroviral therapycohortfollow-upimprovedinsightmenmen who have sex with menphysical processpreventprogramsprophylacticpsychologicrepositoryresponsetherapy developmenttransmission process
项目摘要
This application is Part B of a proposal for a competing renewal to the Pittsburgh component of the
Multicenter AIDS Cohort Study (MACS) Cooperative Agreement (1UO1-AI-35041), the companion to the
Part A composite proposal that is being submitted by CAMACS. The MACS began in 1983 as a longitudinal
study of the natural history of AIDS in men who have sex with men (MSM). This request is for an additional
five years of support for clinical follow-up and laboratory testing of the cohort of MSM in the Pittsburgh
MACS. The broad objectives of the Pittsburgh MACS is to fulfill the specific aims of the Part A master MACS
application, and do special studies locally in Pittsburgh to enhance our epidemiologic and pathogenesis
knowledge in relation to treatment intervention, and development of immunotherapeutic and prophylactic
vaccines. Our specific aims are to determine the long-term natural and treated history of HIV infection in
MSM, characterize the responses to HIV therapy, including psychological and behavioral predictors,
examine the effects of HIV and prolonged HIV therapy exposure on lipodystrophy, diabetes, cardiovascular
disease, liver disease, malignancies, neurocognitive function, substance use, kidney disease, and other
outcomes, assess the effects of aging on the clinical course of HIV and HIV therapy, examine the interaction
between host genetics and HIV, define HIV pathogenesis, characterize HIV-associated cancers including
identification of risk factors, determine socio-behavioral factors that affect HIV transmission and disease
progression, characterize concomitant infections and their effects on HIV disease progression, examine the
effects of substance abuse on antiretroviral treatment effectiveness, maintain longitudinally collected
epidemiological data and biological specimen repository as a platform to facilitate natural history and
pathogenesis studies, perform clinical and lab testing of MSM in the Pittsburgh MACS, including T cell
subsets, anti-HIV Ab, HIV viral load, hepatitis B virus and hepatitis C virus testing, serum lipid/insulin/glucose
levels, liver function tests, renal function and cardiovascular studies. This research has direct relevance to
the mission of the NIH to cure and prevent HIV infection and AIDS.
RELEVANCE (See instructions):
As part of the MACS research consortium, the Pittsburgh MACS proposes to continue its 25 year scientific
investigation into the natural history of HIV/AIDS. This research provides insight into the mechanisms of HIV
infection, the effects of HIV therapy, and development of therapeutic and preventative vaccines for HIV
infection. It is highly relevant to HIV/AIDS public health programs of the NIH.
此申请是一项竞争性更新提案的B部分,以匹兹堡部分的
项目成果
期刊论文数量(0)
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{{ truncateString('CHARLES R RINALDO', 18)}}的其他基金
Cholesterol-dependent control of HIV progression by antigen presenting cells
抗原呈递细胞对 HIV 进展的胆固醇依赖性控制
- 批准号:
8991481 - 财政年份:2015
- 资助金额:
$ 59.12万 - 项目类别:
Cholesterol-dependent control of HIV progression by antigen presenting cells
抗原呈递细胞对 HIV 进展的胆固醇依赖性控制
- 批准号:
8921604 - 财政年份:2015
- 资助金额:
$ 59.12万 - 项目类别:
Immunotherapy with Autologous HIV-Loaded Dendritic Cells
使用携带 HIV 的自体树突状细胞进行免疫治疗
- 批准号:
8091773 - 财政年份:2010
- 资助金额:
$ 59.12万 - 项目类别:
CELL MEDIATED IMMUNITY TO HIV, HCV KSHV INFECTIONS
针对 HIV、HCV KSHV 感染的细胞介导免疫
- 批准号:
7201126 - 财政年份:2005
- 资助金额:
$ 59.12万 - 项目类别:
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