Multicenter AIDS Cohort Study

多中心艾滋病队列研究

• 批准号: 7926541
• 负责人: CHARLES R RINALDO
• 金额: $ 59.12万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-22 至 2012-09-21
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7926541
• 关键词: AIDS/HIV problem; Accounting; Acquired Immunodeficiency Syndrome; Adherence; Adverse effects; Affect; Age; Alcohol or Other Drugs use; Anti-Retroviral Agents; Behavioral; Biological; Cardiovascular Diseases; Cardiovascular system; Clinical; Cohort Studies; Combined Modality Therapy; Companions; Competence; Data; Diabetes Mellitus; Disease; Disease Progression; Dyslipidemias; Epidemiology; Exposure to; Genetic; Glucose; HIV; HIV Infections; HIV drug resistance; HIV therapy; Health; Hepatitis B Virus; Hepatitis C virus; Highly Active Antiretroviral Therapy; Human immunodeficiency virus test; Immune; Immunotherapeutic agent; Incidence; Individual; Infection; Instruction; Insulin; Intervention; Investigation; Kidney Diseases; Knowledge; Laboratories; Lipids; Lipodystrophy; Liver Function Tests; Liver diseases; Long-Term Effects; Longitudinal Studies; Maintenance; Malignant Neoplasms; Mission; Natural History; Neoplasms; Neurocognitive; Outcome; Participant; Pathogenesis; Pattern; Population; Public Health; Recording of previous events; Renal function; Research; Risk Behaviors; Risk Factors; Serum; Specimen; Substance abuse problem; T-Lymphocyte Subsets; Testing; Therapeutic; Treatment Effectiveness; Treatment Protocols; U-Series Cooperative Agreements; United States National Institutes of Health; Vaccines; Viral Load result; age effect; antiretroviral therapy; cohort; follow-up; improved; insight; men; men who have sex with men; physical process; prevent; programs; prophylactic; psychologic; repository; response; therapy development; transmission process

This application is Part B of a proposal for a competing renewal to the Pittsburgh component of the Multicenter AIDS Cohort Study (MACS) Cooperative Agreement (1UO1-AI-35041), the companion to the Part A composite proposal that is being submitted by CAMACS. The MACS began in 1983 as a longitudinal study of the natural history of AIDS in men who have sex with men (MSM). This request is for an additional five years of support for clinical follow-up and laboratory testing of the cohort of MSM in the Pittsburgh MACS. The broad objectives of the Pittsburgh MACS is to fulfill the specific aims of the Part A master MACS application, and do special studies locally in Pittsburgh to enhance our epidemiologic and pathogenesis knowledge in relation to treatment intervention, and development of immunotherapeutic and prophylactic vaccines. Our specific aims are to determine the long-term natural and treated history of HIV infection in MSM, characterize the responses to HIV therapy, including psychological and behavioral predictors, examine the effects of HIV and prolonged HIV therapy exposure on lipodystrophy, diabetes, cardiovascular disease, liver disease, malignancies, neurocognitive function, substance use, kidney disease, and other outcomes, assess the effects of aging on the clinical course of HIV and HIV therapy, examine the interaction between host genetics and HIV, define HIV pathogenesis, characterize HIV-associated cancers including identification of risk factors, determine socio-behavioral factors that affect HIV transmission and disease progression, characterize concomitant infections and their effects on HIV disease progression, examine the effects of substance abuse on antiretroviral treatment effectiveness, maintain longitudinally collected epidemiological data and biological specimen repository as a platform to facilitate natural history and pathogenesis studies, perform clinical and lab testing of MSM in the Pittsburgh MACS, including T cell subsets, anti-HIV Ab, HIV viral load, hepatitis B virus and hepatitis C virus testing, serum lipid/insulin/glucose levels, liver function tests, renal function and cardiovascular studies. This research has direct relevance to the mission of the NIH to cure and prevent HIV infection and AIDS. RELEVANCE (See instructions): As part of the MACS research consortium, the Pittsburgh MACS proposes to continue its 25 year scientific investigation into the natural history of HIV/AIDS. This research provides insight into the mechanisms of HIV infection, the effects of HIV therapy, and development of therapeutic and preventative vaccines for HIV infection. It is highly relevant to HIV/AIDS public health programs of the NIH.

此申请是一项竞争性更新提案的B部分，以匹兹堡部分的