Coordinating Center for Beta Cell Biology Consortium

描述（由申请人提供）：为了响应RFA-DK-09-504，我们提出了β细胞生物学联盟协调中心（BCBC）未来活动的计划。该联盟最初于2001年9月启动，并于2005年更新，为研究如何再生或替换被1型或2型糖尿病破坏或损坏的胰腺细胞提供了一种以团队为导向的方法。协调中心在联盟中发挥着至关重要的作用：1)组织研究者会议和静修，2)维护BCBC网站和试剂数据库，3)监督BCBC核心设施，4)提供先进的生物/信息学应用，5)管理特殊资助计划，6)提供各种类型的行政支持，7)促进与其他nih赞助的中心和联盟的互动。在BCBC的下一个周期中，协调中心将1)继续执行许多正在进行的操作，2)适应科学焦点和新参与者的变化，3)改进网站，以促进团队科学和未发表的知识和试剂的共享。

DESCRIPTION (provided by applicant): In response to RFA-DK-09-504 we present a plan for future activities of the Coordinating Center for the Beta Cell Biology Consortium (BCBC). This consortium, which was initially launched in September 2001 then renewed in 2005, brings a team-oriented approach to studies necessary to learn how to regenerate or replace pancreatic beta cells that are either destroyed or damaged by Type 1 or Type 2 diabetes. The Coordinating Center plays a vital role in the consortium by 1) organizing investigator meetings and retreats, 2) maintaining the BCBC website and reagent databases, 3) overseeing BCBC core facilities, 4) providing advanced bio/informatics applications, 5) managing special funding programs, 6) providing various types of administrative support, and 7) facilitating interactions with other NIH-sponsored Centers and Consortia. During the next cycle of the BCBC the Coordinating Center will 1) continue to perform many ongoing operations, 2) adapt to changes in the scientific focus and new participants, and 3) improve the website in a way to facilitate team science and sharing of unpublished knowledge and reagents. PUBLIC HEALTH RELEVANCE: Type 1 and Type 2 diabetes cause significant morbidity and mortality and thus have an adverse economic impact. Both diseases are characterized by the destruction or dysfunction of insulin-secreting pancreatic beta cells. This application will coordinate activities among a team of scientists in order to develop new, cell-based replacement therapies that hold promise for achieving better glucose control than is currently possible.