Clinical and Autonomic Effects of Mind-Body Exercise in COPD

身心锻炼对慢性阻塞性肺病的临床和自主神经作用

基本信息

批准号：
8145700
负责人：
GLORIA Y YEH
金额：
$ 62.65万
依托单位：
BETH ISRAEL DEACONESS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-30 至 2015-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8145700
关键词：
Activities of Daily Living Adherence Aerobic Exercise Attention Biological Markers Breathing Breathing Exercises C-reactive protein California Cardiac Cardiopulmonary Cardiovascular system Cause of Death Chinese People Chronic Chronic Obstructive Airway Disease Clinic Clinical Clinical Treatment Data Disease Disease Management Disease Progression Disease model Dyspnea Education Exercise Exercise Tolerance Exertion Exhibits Functional disorder General Population Goals Healed Heart failure Individual Inflammation Interleukin-6 Intervention Investigation Lung Martial Arts Measures Mediating Medical Mind-Body Intervention Moods Morbidity - disease rate Obstructive Lung Diseases Operative Surgical Procedures Outcome Outcome Measure Outpatients Oxygen Patients Physical activity Physiological Population Prevalence Primary Health Care Public Health Quality of life Questionnaires Randomized Controlled Trials Recruitment Activity Rehabilitation therapy Relaxation Reporting Research Role Self Efficacy Self Perception Serum Shortness of Breath Skeletal Muscle Smoking Social support Staging Stress Stress Tests Symptoms System Tai Ji Techniques Time Training Tumor Necrosis Factor-alpha United States Universities Walking arm body-mind center for epidemiological studies depression scale clinical efficacy design flexibility functional status group intervention healing health related quality of life heart rate variability human TNF protein improved indexing insight lung volume mortality novel novel strategies patient oriented primary outcome programs psychosocial public health relevance respiratory stress management trend uptake

项目摘要

DESCRIPTION (provided by applicant): Chronic obstructive pulmonary disease (COPD) is a major public health problem and is the fourth leading cause of death in the United States. Despite pharmacologic and surgical therapy, COPD continues to cause considerable morbidity and mortality and is the only major disease among the top ten that continues to increase in prevalence. Novel and inexpensive interventions that can improve symptoms, health-related quality-of-life, functional capacity, and potentially modify disease progression are needed. Tai chi is a popular mind-body exercise that combines gentle physical activity, self awareness, and relaxation with slow mind-body breathing. It may be particularly suited to deconditioned individuals with COPD, who suffer from limited exercise tolerance and shortness of breath on exertion, and it integrates multiple components relevant to COPD management, including low-intensity aerobic exercise, stress management and slow mind-body breathing training. In this application, we propose a 3-arm randomized controlled trial (N=102) to evaluate the benefits of tai chi exercise (which includes mind-body breathing) versus seated mind-body breathing alone (an isolated, key component of the comprehensive tai chi program) versus education control. This design will allow us to examine the individual efficacy of each mind-body intervention on clinical outcomes in COPD, but will also allow clinical and physiological comparisons between the two interventions, providing insight into the components and mechanisms of mind-body therapies. Patients with COPD (Global Obstructive Lung Disease stages 1-3 with symptoms of dyspnea) will be recruited from outpatient primary care and pulmonary clinics. Our primary aim will be to examine the effects of tai chi and mind-body breathing on quality-of-life and exercise capacity in this population. Secondary aims will further explore the effects on clinical symptoms, psychosocial indices, cardiopulmonary function, strength and flexibility, biomarkers of systemic inflammation, and autonomic activity. The results of our proposed research will help inform clinical treatment of COPD, and further our mechanistic understanding of mind-body exercises and the role of slow, mind-body breathing. PUBLIC HEALTH RELEVANCE: Chronic obstructive pulmonary disease (COPD) is a major public health problem and is the fourth leading cause of death in the United States. This proposed study examines tai chi, a promising mind- body exercise, and one of its key components, slow mind-body breathing, that may be particularly relevant and beneficial to patients with COPD. The results of this study will help inform clinical treatment of COPD, and further our mechanistic understanding of mind-body therapies in general and the role of slow mind-body breathing.

描述（由申请人提供）：慢性阻塞性肺疾病（COPD）是一个主要的公共卫生问题，是美国第四大死亡原因。尽管药理和手术疗法，COPD仍会继续引起相当大的发病率和死亡率，并且是前十名中唯一的主要疾病，它继续增加患病率。需要改善症状，与健康相关的生活质量，功能能力以及可能改变疾病进展的新型干预措施。太极拳是一种流行的心身运动，结合了轻柔的体育锻炼，自我意识和放松身心的呼吸缓慢。它可能特别适合于患有COPD的人，他们的运动耐受性和呼吸不足，并且整合了与COPD管理相关的多个组件，包括低强度有氧运动，压力管理和缓慢的身心呼吸训练。在此应用程序中，我们提出了一项3臂随机对照试验（n = 102），以评估太极拳运动的好处（包括思维呼吸）与坐着的思维体呼吸（综合泰式tai chi计划的孤立，关键的组成部分）与教育控制。这种设计将使我们能够检查COPD中每种心身干预对临床结果的个人功效，但还可以允许两种干预措施之间的临床和生理比较，从而深入了解思维疗法的成分和机制。 COPD患者（全球阻塞性肺部疾病阶段1-3患有呼吸困难症状）将从门诊初级保健和肺部诊所招募。我们的主要目的是检查太极拳和思维呼吸对这种人群中生活质量和运动能力的影响。次要目的将进一步探讨对临床症状，社会心理指数，心肺功能，力量和灵活性，全身炎症的生物标志物和自主性活动的影响。我们提出的研究的结果将有助于为COPD的临床治疗提供信息，并进一步我们对心身锻炼的机械理解以及缓慢的，身心呼吸的作用。公共卫生相关性：慢性阻塞性肺疾病（COPD）是一个主要的公共卫生问题，是美国第四大死亡原因。这项拟议的研究研究了Tai Chi，一种有前途的身心运动及其关键成分之一，即缓慢的思维体呼吸，这可能对COPD患者特别相关且有益。这项研究的结果将有助于为COPD的临床治疗提供信息，并进一步我们对心身疗法的机械理解以及慢速身心呼吸的作用。