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Rocky Mountain Neurological Disorders Core

落基山神经疾病核心

基本信息

批准号：
8374791
负责人：
Angeles Badell Ribera
金额：
$ 4.17万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-09-15 至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8374791
关键词：
Animal Model Animals Appointment Area Award Basic Science Behavioral Biochemistry Biological Models Biophysics Clinical Collaborations Colorado Core Facility Developmental Cell Biology Disease Electron Microscopy Epilepsy Faculty Fluorescence Fostering Funding Gene Targeting Generations Genetic Goals Ice Individual Instruction Laboratories Measurement Medical Microbiology Microscopy Molecular Mus Names National Institute of Neurological Disorders and Stroke Neurobiology Neurosciences Neurosciences Research Pediatric Neurology Pharmacologic Substance Pharmacology Pharmacy Schools Phenotype Physiology Positioning Attribute Rattus Recruitment Activity Research Research Infrastructure Research Personnel Research Project Grants Research Support Rodent Science Secure Seizures Services Techniques Transgenic Mice Transgenic Organisms Translational Research Universities Ursidae Family Viral Viral Vector Zebrafish base design and construction experience interest light microscopy medical schools meetings molecular imaging nervous system disorder positional cloning professor programs synaptic function translational neuroscience translational study vector

项目摘要

PROJECT SUMMARY (See instructions): This Is a competitive renewal of the Rocky Mountain Neurological Disorder Center (RMNOC) whose main goal Is to enhance and further research in areas of neurobiology targeted by the NINOS. The RMNO Center Core has established facilities that allow efficient generation and use of genetically-altered animals that display Interesting and Informative functional or behavioral phenotypes. Our existing cores have all been extremely successful and evolved to enable state-of-the-art approaches thereby allowing users to perform collaborative research in an efficient manner. Therefore, we propose to maintain the original cores with their original names, emphasizing that they will continue to evolve over the next five years, as described in the application (Cores A, 6, C, and 0). As before, the services provided by the four cores are not available elsewhere at the Anschutz Medical Campus. We propose four core facilities for the RMNO Center Core: Core A Microscopy Core (Bill Betz, Director) will provide advanced light and electron microscopy services. Core B Gene-Targeting/Viral Vector Core (Mark Dell'Acqua, Director) \N\\\ design and construct vectors to generate gene-targeted and transgenic mice as well as viral targeting vectors. Core C Zebrafish Transgenic Core (Angeles Ribera, Director)m\\ provide services for maintaining and characterizing transgenic zebraflsh. Core D Machine Shop Core (Ulli Bayer, Director) will provide machine shop support services.

项目概述（见说明）：