Rocky Mountain Neurological Disorders Core Center

 描述(由申请人提供)：落基山神经疾病中心核心(RMNDC)的主要目标是提供资源，使安舒茨医学院的神经科学家能够将变革性技术融入他们的研究中。在这里，我们的目标是相对较新的尖端神经科学工具，这些工具被认为将对我们正在进行的研究产生最大的影响，使研究人员能够将强大的新方法纳入他们的研究计划，并催化新的合作。我们提出了三个研究核心(A，光遗传学和神经工程；B，纳米显微镜；C，行为和活体神经生理学)，将提供强大的工具，从战略上促进我们神经科学界的研究和生产力的影响。新的核心将提供校园内其他地方无法提供的服务。此外，这些核心侧重于对我们的神经科学界具有高度影响和使用的研究工具。我们优先为岩心配备设备和工具方面的专家，以便调查人员在没有 以前的经验将能够适当地将新方法纳入他们的研究计划，并达到最严格的标准。总体而言，这些核心将开辟新的研究途径，这些研究对于目前44个区域和国家发展委员会绩效指标的持续工作至关重要。因此，这些核心将促进关于神经系统发育和功能的基本机制的研究，这是寻找创新和更有效的神经疾病治疗方法所必需的。

 DESCRIPTION (provided by applicant): The primary goal of the Rocky Mountain Neurological Disorders Center Core (RMNDC) is to provide resources that will allow neuroscientists on the Anschutz Medical Campus to incorporate transformative technologies into their research. Here, we target cutting edge neuroscience tools that are relatively new and considered to be those that will have the highest impact on our on-going research, allow investigators to incorporate powerful new approaches into their research programs and catalyze new collaborations. We propose three Research Cores (A, Optogenetics & Neural Engineering; B, Nanoscopy; C, Behavioral and In Vivo Neurophysiology) that will provide powerful tools that advance strategically the impact of the research and productivity of our neuroscience community. The new Cores will provide services not available elsewhere on campus. Moreover, these Cores focus on research tools that are of high impact and use to our neuroscience community. We prioritize staffing the Cores with experts in the equipment and tools so that investigators without prior experience will be in a position to incorporate new methods into their research programs appropriately and to the most exacting standards. Overall, the Cores will open up new avenues of research that are essential for on-going work of the current 44 RMNDC PIs. Thus, the Cores will promote research regarding fundamental mechanisms underlying nervous system development and function that is required to find innovative and more effective treatments for neurological disease.