2012 Microbial Stress Response Gordon Research Conference

描述(由申请人提供)：本提案请求对2012年7月15-20日在马萨诸塞州南哈德利的芒特霍利克学院举行的2012年微生物应激响应戈登研究会议提供部分支持。2012年微生物应激反应会议将提供一个论坛，公开报告在研究单个微生物和微生物群落如何应对应激方面的最新进展。这个一年两次的会议传统上吸引了生物和物理学家，利用遗传学、细胞生物学、基因组和计算技术，研究与医学、环境和生物技术相关的微生物以及模型生物的应激反应。2012年的会议将整合描述从单一微生物到群落的应激反应的尖端、遗传、分子和计算方法的会议。我们计划在2012年的会议上强调剖析压力反应的新方法的影响。例如，2012年的会议是利用高通量测序和基因组技术研究群落中微生物应激反应的研究人员与分析纯培养和模式生物的科学家之间进行深入对话的完美场所。我们希望这种对话将使所有参与者受益，为分析复杂微生物群落的研究人员提供基本的生物学见解，并向研究纯培养的科学家通报深度测序和其他高通量技术在具有医疗、环境和生物技术意义的生态系统中所取得的进展。我们预测，这次会议将增进对生物、技术和计算问题的理解，促进科学讨论，并在研究不同时间、组织和社区尺度的应激反应的研究人员之间促进新的合作。从许多标准来看，这次会议都非常成功，而且传统上有一份感兴趣的与会者的等待名单。由于社区的兴趣，微生物应激反应会议在戈登研究会议的会场举行，该会场可容纳约175人，可容纳约60名学生、博士后和其他研究人员的海报。它的规模足够大，可以包括不同的观众，但其规模和长度允许与会者进行深入讨论和相当多的互动。会议组织者致力于延续本次会议参与者多元化的传统，并将努力确定和吸收妇女、代表性不足群体的成员和初级科学家作为发言者或参与者。 公共卫生相关性：应激反应对于细菌生长、建立有益的微生物-宿主相互作用以及病原体定植宿主、启动毒力计划和抵抗抗菌素治疗至关重要。在这次会议上提出的新结果将帮助社区了解应激反应如何控制有益和致病微生物的活动，并制定改善人类健康的战略。NIH基金将帮助支持人口统计学上不同受众的参与，这些受众包括在分子、社区和生态系统层面研究压力反应的生物学家、物理学家、工程师和计算生物学家。

DESCRIPTION (provided by applicant): This proposal requests partial support for the 2012 Microbial Stress Response Gordon Research Conference to be held July 15-20, 2012 at Mount Holyoke College, South Hadley, MA. The 2012 Microbial Stress Response meeting will provide a forum for open reporting of recent advances from studying how individual microbes and microbial communities to respond to stress. This biannual conference traditionally attracts biological and physical scientists studying stress responses in medical, environmental, and biotechnology-relevant microbes as well as in model organisms, using genetic, cell biological, genomic and computational techniques. The 2012 meeting will integrate sessions describing cutting edge, genetic, molecular, and computational approaches to stress responses spanning from single microbes to communities. We plan to highlight the influence of new approaches to dissecting stress responses in the 2012 meeting. For example, the 2012 meeting is the perfect venue for in depth dialogue between researchers using high throughput sequencing and genomic techniques to study microbial stress responses in communities and scientists analyzing pure cultures and model organisms. We expect this dialogue will benefit all participants, providing basic biological insight to researchers analyzing complex microbial communities and informing scientists studying pure cultures of advances coming from deep-sequencing and other high throughput techniques in ecosystems of medical, environmental and biotechnological significance. We predict the conference will increase understanding of the biological, technical and computational issues, foster scientific discussions, and catalyze new collaborations among researchers studying stress responses at different temporal, organismal and community scales. This meeting is very successful by many criteria, and traditionally has a waiting list of interested attendees. Due to community interest, the Microbial Stress Response meeting is held in a Gordon Research Conference venue that houses ~175 and can accommodate ~60 posters by students, post-doc and other researchers. It is large enough to include a diverse audience but of a size and length that allows deep discussion and considerable interaction among attendees. The meeting organizers are committed to continue this meeting's tradition of participant diversity and will work to identify and include women, members of underrepresented groups and junior scientists as speakers or participants. PUBLIC HEALTH RELEVANCE: Stress responses are critical to bacterial growth, establishment of beneficial microbe-host interactions, as well as for pathogens to colonize hosts, initiate virulence programs and resist antimicrobial treatments. The new results presented at this meeting will help the community understand how stress responses control activities of beneficial and pathogenic microbes and develop strategies to improve human health. NIH funds will help support participation by a demographically diverse audience of biologists, physical scientists, engineers and computational biologists who study stress responses at the molecular, community and ecosystem levels.