Pathology and Biorepository

项目总结(见说明)： 马里兰大学Marlene和Stewart Greenebaum癌症中心(UMGCC)的病理和生物库共享服务(PBSS)有两个主要任务：(1)在保持患者机密性的同时，提供一贯高质量的患者样本(组织和其他制剂)；(2)提供病理学、组织学和组织技术咨询服务，以协助临床研究人员 在人类组织标本的获取、分析和临床病理相关性方面。通过获取组织标本，研究人员可以进行分析(例如，基因组或蛋白质组研究)，以了解正常和疾病组织的生物学，然后将这些知识转化为诊断和临床应用。PBSS是唯一的组织库共享服务，用于在手术中取出的标本 马里兰大学巴尔的摩分校(UMB)。PBSS与病理学系的解剖病理学司建立了综合关系，这对于获得具有良好特征的组织样本以及病理学和组织学专业知识至关重要。除了所有已售出肿瘤的持续库存外，PBSS还提供研究人员特定组织的采购和处理；访问超过7,000个 冰冻的肿瘤样本，其中5,900个与同一患者的正常组织配对；以及查阅解剖病理实验室的福尔马林固定石蜡包埋(FFPE)样本档案，其中包括1,260,000多个具有各种病理诊断的FFPE组织块。PBSS执行对冷冻样本库和外科病理档案的搜索，以获取特定样本集， 随后由Olgaloffe博士或William Twaddell博士取回标本并确认相关病变/肿瘤的存在。根据具体的研究问题，可根据要求提供临床病理参数。PBSS员工在各种技术方面拥有丰富的经验 和标本类型。PBSS提供与病理学家的咨询，以制定方案和进行组织评估；机构审查委员会问题；技术支持；以及研究标本的常规组织学和免疫组织化学分析、数字图像分析和组织微阵列构建方面的专业知识。PBSS的成功和有效性是基于其将其病理和 UMGCC正在进行的研究中使用了生物库资源和专业知识。

PROJECT SUMMARY (See instructions): The Pathology and Biorepository Shared Service (PBSS) at the University of Maryland Marlene and Stewart Greenebaum Cancer Center (UMGCC) has two main missions: (1) provide access to a consistently excellent quality of banked patient samples (tissue and other preparations) while maintaining patient confidentiality and (2) provide pathology, histology, and histotechnology consultation services to assist clinical investigators in the procurement, analyses, and clinicopathologic correlation of human tissue specimens. Through access to tissue specimens, investigators can perform analyses (e.g., genomic or proteomic studies) to understand the biology of normal and diseased tissues and then translate that knowledge for diagnostic and clinical applications. PBSS is the only tissue bank shared service for specimens removed at surgery at the University of Maryland-Baltimore (UMB) campus. PBSS has an integrated relationship with the Division of Anatomic Pathology of the Department of Pathology, which is essential for obtaining well-characterized tissue samples and pathology and histology expertise. In addition to the ongoing banking of all sold tumors,PBSS also provides investigator-specific tissue procurement and processing; access to more than 7,000 frozen tumor samples, of which 5,900 are paired with normal tissue from the same patient; and access to the formalin-fixed paraffin-embedded (FFPE) specimen archive of the Anatomic Pathology Laboratory, which consists of more than 1,260,000 FFPE tissue blocks with various pathologic diagnoses. PBSS performs searches of the frozen sample library and the surgical pathology archive for sets of specific samples, with subsequent retrieval of specimens and confirmation ofthe presence of relevant lesion/tumor by Drs. Olgaloffe or William Twaddell. The provision of clinicopathologic parameters is available upon request, depending on the specific research question. PBSS staff possess extensive experience with a wide range of techniques and specimen types. PBSS offers consultation with pathologists for protocol development and tissue evaluation; Institutional Review Board issues; technical support; and expertise for routine histological and immunohistochemical analyses of research specimens, digital image analysis, and tissue microarray construction. The success and effectiveness of PBSS is based on its ability to integrate its pathology and biorepository resources and expertise into research being conducted at UMGCC.