Hot flashes and memory dysfunction in the perimenopause

围绝经期的潮热和记忆功能障碍

• 批准号: 8565101
• 负责人: Miriam T. Weber
• 金额: $ 7.31万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8565101
• 关键词: Accounting; Affect; Aging; Alzheimer' s Disease; Ambulatory Monitoring; Attention; Biological Preservation; Clinical Trials; Cognition; Cognitive; Episodic memory; Event; Frequencies; Functional disorder; Funding; Health; Hormonal; Hot flushes; Hour; Impaired cognition; Intervention; Investigation; Laboratories; Lead; Link; Longitudinal Studies; Measures; Memory; Memory impairment; Menopausal Symptom; Menopause; Menstruation; Mental Depression; Meta-Analysis; Monitor; Motor; N-formylmethionylphenylalanine; Night Sweating; Outcome; Participant; Patient Self-Report; Pattern; Performance; Perimenopause; Physiological; Postmenopause; Premenopause; Prospective Studies; Reporting; Risk; Risk Factors; Severities; Sleep; Sleep disturbances; Symptoms; Testing; Therapeutic Intervention; Time; Vasomotor; Woman; Work; actigraphy; cognitive change; cognitive function; diaries; experience; hormone therapy; improved; indexing; middle age; non-compliance; processing speed; public health relevance; reproductive; sex; sexual dimorphism

DESCRIPTION (provided by applicant): The overall aim of this investigation is to determine if vasomotor symptoms (VMS; hot flashes and night sweats) are a mechanism for memory changes in the transition from premenopause to perimenopause to postmenopause. The menopausal transition (MT) is associated with subtle declines in processing speed, motor function, verbal fluency and verbal episodic memory1-4. Evidence suggests a direct influence of hormonal transitions on these sexually dimorphic cognitive domains, though the exact mechanism is not known. It has been proposed that vasomotor symptoms (VMS, hot flashes and night sweats), are associated with cognition during the MT, but prior studies have focused exclusively on subjectively reported, but not objectively measured, VMS. The current application builds on prior work from this laboratory demonstrating cognitive declines in the first year after the final menstrual period, and that objectively measured VMS are associated with verbal episodic memory in post-menopausal women. The specific aims are to examine the relationship between objectively measured hot flashes and cognitive function, both immediately and longitudinally across the MT, after accounting for objectively measured sleep. In this study, ambulatory monitoring of VMS and sleep will be incorporated into an ongoing, NIA-funded prospective study of cognitive changes during the MT to evaluate the immediate and cumulative effect of hot flashes on cognition. It is hypothesized that objective VMS will have a negative impact on verbal memory performance in perimenopause and that changes in hot flash frequency will predict changes in verbal memory performance over time. Findings from these studies will inform our understanding of memory dysfunction in the MT and the potential of using VMS as a measure of risk for cognitive decline, which would highlight an important target for therapeutic intervention.

描述(申请人提供)：这项研究的总体目标是确定血管运动症状(VMS；潮热和盗汗)是否是绝经前、围绝经期和绝经后记忆变化的一种机制。绝经过渡(MT)与处理速度、运动功能、语言流畅性和语言情景记忆1-4的微妙下降有关。有证据表明，荷尔蒙变化对这些性二态认知域有直接影响，尽管确切的机制尚不清楚。有研究认为，血管运动症状(VMS、潮热和盗汗)与MT期间的认知有关，但先前的研究主要集中在主观报告的VMS上，而不是客观测量的VMS上。目前的应用建立在该实验室之前的工作基础上，该工作表明，在最后一个月经期后的第一年，认知能力下降，客观测量的VMS与绝经后女性的言语情景记忆有关。具体目的是在考虑客观测量的睡眠后，检查客观测量的潮热和认知功能之间的关系，包括即时和纵向的MT。在这项研究中，对VMS和睡眠的动态监测将被纳入一项正在进行的、由NIA资助的关于MT期间认知变化的前瞻性研究，以评估潮热对认知的即时和累积影响。假设客观VMS将对围绝经期的言语记忆表现产生负面影响，而热闪光频率的变化将预测随着时间的推移言语记忆表现的变化。这些研究的结果将有助于我们理解MT的记忆功能障碍，以及使用VMS作为认知功能下降风险的衡量标准的可能性，这将突出治疗干预的重要靶点。