Hormones and Cognition Over the Lifespan

一生中的激素和认知

• 批准号: 8520137
• 负责人: Miriam T. Weber
• 金额: $ 14.84万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8520137
• 关键词: Age; Age-associated memory impairment; Aging; Alzheimer' s Disease; Behavioral; Brain; Clinical; Clinical Trials; Cognition; Cognitive; Cognitive aging; Cognitive deficits; Dementia; Dendritic Spines; Development; Elderly; Endocrinology; Epidemiology; Estrogens; Event; Female; Foundations; Hormonal; Hormonal Change; Hormones; Hot flushes; Impaired cognition; Investigational Therapies; K-Series Research Career Programs; Knowledge; Lead; Life Cycle Stages; Longevity; Measurable; Measures; Mediating; Memory; Menopause; Mentored Patient-Oriented Research Career Development Award; Mentors; Methodology; Neuropsychology; Neurosciences; Outcome; Pattern; Performance; Perimenopause; Postpartum Period; Pregnancy; Pregnant Women; Research; Research Personnel; Research Proposals; Research Training; Risk; Risk Factors; Series; Sleep disturbances; Time; Training Programs; Woman; Work; axonal sprouting; cholinergic; critical period; depressive symptoms; experience; hypothalamic pituitary gonadal axis; improved; mild cognitive impairment; neuron loss; prevent; programs; protective effect; reproductive; reproductive hormone; statistics

Reproductive hormones have several protective effects on the brain, such as promoting cholinergic activity, reducing neuronal loss, and stimulating axonal sprouting and dendritic spine formation. In this application, it is hypothesized that reproductive events characterized by significant hormonal fluctuation (such as pregnancy and the menopausal transition) are associated with measurable decreases in cognition, and that multiple periods of estrogen depletion increases the risk of cognitive decline and dementia in later life. The overall aim of this Mentored Patient-Oriented Research Career Development Award (K23) is to lay the foundation for a programmatic approach to the study of hormones and cognition in women across the lifespan and to facilitate the candidate's development into an independent clinical neuroscience researcher. The candidate has extensive training and research experience in the neuropsychology of aging, dementia, and perimenopause and clinical trial methodology. The training program focuses on increasing knowledge and expertise in additional fields critical to this program of study: behavioral neuroscience, endocrinology, epidemiology, and statistics. The research proposal aims to clarify how hormonal changes during critical periods in the female reproductive life cycle might increase the risk of cognitive decline and Alzheimer's disease in later life and to develop a working hypothesis of how and when to intervene with experimental therapies aimed at preventing or limiting this outcome. The specific aims of the research plan are to: 1) determine if pregnancy is associated with measurable cognitive declines and if such declines ameliorate in the postpartum period, and 2) determine if the menopausal transition (MT) is associated with subjective and objective cognitive declines that ameliorate in menopause. Secondary aims are to determine the risk factors of cognitive impairment in the MT and to determine if cognitive impairments during the MT are predictive of age-related cognitive decline.

生殖激素对大脑有几种保护作用，例如促进 胆碱能活性，减少神经元损失，刺激轴突发芽， 树突棘形成。在本申请中，假设生殖事件 以显著的荷尔蒙波动为特征（如怀孕和 绝经过渡期）与认知能力的可测量下降有关， 多个时期的雌激素消耗增加了认知能力下降的风险， 老年痴呆症后期这个以患者为导向的指导研究职业的总体目标 发展奖（K23）是为项目方法奠定基础， 研究女性一生中的激素和认知能力， 候选人的发展成为一个独立的临床神经科学研究员。的 候选人在神经心理学方面有丰富的培训和研究经验， 衰老、痴呆和围绝经期以及临床试验方法学。培训 该计划的重点是增加知识和专业知识，在其他领域的关键， 该研究计划：行为神经科学，内分泌学，流行病学， 统计这项研究提案旨在阐明在关键时期荷尔蒙是如何变化的。 女性生殖生命周期中的某些时期可能会增加认知能力下降的风险， 和老年痴呆症的关系，并提出一个工作假设， 何时干预旨在预防或限制这种情况的实验性疗法 结果。研究计划的具体目标是：1）确定怀孕是否 与可测量的认知下降相关，如果这种下降在 产后期，和2）确定绝经过渡期（MT）是否与 主观和客观认知能力下降，在更年期有所改善。二次 目的是确定MT中认知障碍的危险因素，并确定 如果MT期间的认知障碍预示着与年龄相关的认知衰退。