Cognition, Mood and Hormones in Perimenopause

围绝经期的认知、情绪和激素

• 批准号: 7493454
• 负责人: Miriam T. Weber
• 金额: $ 6.79万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-15 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7493454
• 关键词: Affect; Affective; Age; Anxiety; Caring; Cognition; Cognitive; Cognitive deficits; Dementia; Development; Disease regression; Early identification; Equation; Estradiol; Estrogens; Goals; Health; Hormonal; Hormones; Impaired cognition; Individual; Life; Measures; Mediating; Menopause; Modeling; Moods; Nature; Neurodegenerative Disorders; Neuropsychological Tests; Pattern; Performance; Perimenopause; Physiological; Pilot Projects; Provider; Psychosocial Assessment and Care; Relative (related person); Reporting; Risk; Score; Serum; Symptoms; Testing; Time; Visit; Woman; age related; cognitive change; depressive symptoms; experience; neuropsychological; psychologic; psychosocial; reproductive hormone; stressor

DESCRIPTION (provided by applicant): The menopausal transition may represent a critical developmental time period during which subtle cognitive deficits may be revealed. The pattern of cognitive deficits which may be seen during this time period may be useful for identifying individuals who are at risk for developing dementia later in life. The overall goal of this study is to determine if cognitive deficits described by many perimenopausal women can be objectively measured. We will also examine the affective and hormonal milieu in which these deficits may exist and how these factors are related to reported cognitive changes. The specific aims of this pilot study are to determine if objective cognitive deficits are present in perimenopausal women and to determine if putative estrogen effects on cognitive performance are mediated by estrogen effects on mood state. 30 early- perimenopausal and 30 late-perimenopausal women between the ages of 40 and 60 will be evaluated at 6- month intervals for one year. Comprehensive neuropsychological (NP) assessment, psychological assessment, psychosocial and health assessment, and reproductive hormone levels will be obtained at each visit. Early and late perimenopausal women will be compared with respect to NP test performance and mood and anxiety symptoms using t-tests. Regression/correlation analyses will be performed to investigate the associations between hormones, NP test performance, and mood and anxiety symptoms. To determine if the relationship between estrogen and cognition is mediated by estrogen's relationship with mood, we will use structural equation modeling (SEM). The findings of this study may influence current treatment of perimenopausal women, who are often faced with significant psychosocial stressors and age-related physiologic changes during this time period. An understanding of the nature of cognitive declines, and whether they are transient or signify a risk for neurodegenerative disease, would either alleviate women's concerns about subjective cognitive lapses or allow for early identification and treatment. An understanding of the possible mechanisms of such declines would assist care providers in their treatment and referral of women with cognitive and psychological symptoms.

描述（由申请人提供）：绝经过渡期可能是一个关键的发育时期，在此期间可能会发现微妙的认知缺陷。在这段时间内可能看到的认知缺陷模式可能有助于识别在以后的生活中有患痴呆症风险的个体。本研究的总体目标是确定是否可以客观地测量许多围绝经期妇女所描述的认知缺陷。我们还将研究这些缺陷可能存在的情感和激素环境，以及这些因素如何与报告的认知变化相关。这项试点研究的具体目的是确定是否客观认知缺陷存在于围绝经期妇女，并确定是否推定的雌激素对认知能力的影响是由雌激素对情绪状态的影响介导的。年龄在40至60岁之间的30名围绝经期早期和30名围绝经期晚期女性将每隔6个月进行一年的评价。每次访视时将获得全面的神经心理学（NP）评估、心理评估、心理社会和健康评估以及生殖激素水平。将使用t检验比较围绝经期早期和晚期女性的NP测试表现以及情绪和焦虑症状。将进行回归/相关分析，以研究激素、NP测试表现与情绪和焦虑症状之间的相关性。为了确定雌激素和认知之间的关系是否是由雌激素与情绪的关系介导的，我们将使用结构方程模型（SEM）。这项研究的结果可能会影响目前的治疗围绝经期妇女，谁往往面临着显着的心理社会压力和年龄相关的生理变化，在这段时间内。了解认知下降的性质，以及它们是短暂的还是意味着神经退行性疾病的风险，将减轻女性对主观认知失误的担忧，或者允许早期识别和治疗。了解这种下降的可能机制将有助于护理提供者治疗和转介有认知和心理症状的妇女。