Acquisition of a Nano Computed Tomography Instrument for shared Cornell Imaging f

购买纳米计算机断层扫描仪用于共享康奈尔成像 f

• 批准号: 8333738
• 负责人: Christopher John Hernandez
• 金额: $ 75.47万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-20 至 2014-04-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8333738
• 关键词: Biological Sciences; Congenital Abnormality; Contrast Media; Defect; Degenerative polyarthritis; Development; Devices; Funding; Future; Health; Heart; Image; Imagery; In Vitro; Investigation; Malignant neoplasm of lung; Medical Research; Microscopy; New York; Osteoporosis; Phase; Pre-Eclampsia; Principal Investigator; Research; Resolution; Scanning; Specimen; United States National Institutes of Health; Universities; X-Ray Computed Tomography; bone; design; in vivo; instrument; meetings; nano; novel; soft tissue; submicron; therapy development

DESCRIPTION (provided by applicant): This is a request for funds for an Xradia VersaXRM-500 micro- and nano-computed tomography instrument. The requested instrument will expand the Cornell Micro-CT facility from in vivo scanning (25 micrometer resolution) to in vitro scanning (0.56 micrometer resolution) to meet the medical research needs of 10 principal investigators with NIH funding. The new instrument will be located within and managed by the Cornell University Microscopy and Imaging Facility, whose main focus is to support imaging needs on campus and in central New York. The Microscopy and Imaging Facility is located within the newly built, $160 million Weill Hall facility that was designed to the be the hub for Cornell's New Life Sciences Initiative. The Xradia VersaXRM- 500 device has novel capabilities including sub-micron resolution in specimens larger than 4mm in size and phase contrast enhanced computed tomography allowing visualization and assessment of soft tissues with or without contrast agents. The instrument will directly enhance the research needs of 9 major users, each of whom have found that existing imaging approaches are not sufficient for their current and future needs. The device will be used immediately to enhance research on a) the development and treatment of osteoporosis and other defects in bone; b) treatment of osteoarthritis; c) the development of lung cancer; e) uterine pre- eclampsia; d) congenital defects in the heart and will be used in future investigations on these health topics and others.

描述（由申请人提供）：这是购买 Xradia VersaXRM-500 微米和纳米计算机断层扫描仪器的资金请求。所需仪器将康奈尔大学 Micro-CT 设施从体内扫描（25 微米分辨率）扩展到体外扫描 （0.56 微米分辨率）可满足 NIH 资助的 10 名主要研究人员的医学研究需求。新仪器将位于康奈尔大学显微镜和成像设施内并由其管理，该设施的主要重点是支持校园和纽约市中心的成像需求。显微镜和成像设施位于耗资 1.6 亿美元新建的威尔霍尔设施内，该设施旨在成为康奈尔大学新校区的中心。 生命科学倡议。 Xradia VersaXRM-500 设备具有新颖的功能，包括尺寸大于 4 毫米的标本的亚微米分辨率和相差增强计算机断层扫描，允许使用或不使用造影剂对软组织进行可视化和评估。该仪器将直接增强 9 个主要用户的研究需求，他们每个人都发现现有的成像方法不足以满足他们当前和未来的需求。该设备将立即用于加强以下方面的研究：a) 骨质疏松症和其他骨缺陷的发展和治疗； b) 骨关节炎的治疗； c) 肺癌的发展； e) 子宫先兆子痫； d) 先天性心脏缺陷，并将用于未来对这些健康主题和其他主题的调查。

项目成果

Experimental and computational understanding of pulsatile release mechanism from biodegradable core-shell microparticles.

• DOI: 10.1126/sciadv.abn5315
• 发表时间: 2022-07-15
• 期刊: Science advances
• 影响因子: 13.6

Oceanic intraplate explosive eruptions fed directly from the mantle

海洋板内爆炸性喷发直接来自地幔

• DOI: 10.1073/pnas.2302093120
• 发表时间: 2023
• 期刊: Proceedings of the National Academy of Sciences
• 作者: DeVitre, Charlotte L.;Gazel, Esteban;Ramalho, Ricardo S.;Venugopal, Swetha;Steele-MacInnis, Matthew;Hua, Junlin;Allison, Chelsea M.;Moore, Lowell R.;Carracedo, Juan Carlos;Monteleone, Brian
• 通讯作者: Monteleone, Brian

Finite element modelling of sound transmission in the Weberian apparatus of zebrafish (Danio rerio).

• DOI: 10.1098/rsif.2023.0553
• 发表时间: 2024-01
• 期刊: Journal of the Royal Society, Interface

Deep three-photon imaging of the brain in intact adult zebrafish

• DOI: 10.1038/s41592-020-0819-7
• 发表时间: 2020-04-27
• 期刊: NATURE METHODS
• 影响因子: 48
• 作者: Chow, Dawnis M.;Sinefeld, David;Fetcho, Joseph R.
• 通讯作者: Fetcho, Joseph R.

Shark teeth as edged weapons: serrated teeth of three species of selachians.

作为利器的鲨鱼牙齿：三种鲨鱼的锯齿状牙齿。

• DOI: 10.1016/j.zool.2016.05.007
• 发表时间: 2017
• 期刊: Zoology (Jena, Germany)
• 作者: Moyer,JoshuaK;Bemis,WilliamE
• 通讯作者: Bemis,WilliamE