BIOMIMETIC SCAFFOLD FOR BONE-REPAIR
用于骨修复的仿生支架
基本信息
- 批准号:7218004
- 负责人:
- 金额:$ 30.9万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2004
- 资助国家:美国
- 起止时间:2004-07-01 至 2009-03-31
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAdhesivesAlkaline PhosphataseApatitesAreaBiocompatibleBiocompatible MaterialsBiodegradationBiologicalBiological ProcessBiomimeticsBlood VesselsBone MatrixBone RegenerationBone TissueC-terminalCell AdhesionCell surfaceCellsCharacteristicsCircular DichroismClinicalCollagenCollagen Type IConditionConfocal MicroscopyDefectDentalDentinDepositionDiagnostic radiologic examinationDifferentiation and GrowthElectron MicroscopyEmbryoEngineeringEnvironmentExtracellular MatrixExtracellular Matrix ProteinsFacility Construction Funding CategoryFibronectinsFlow CytometryFractureGenesGenetic EngineeringGoalsHydrogelsHydroxyapatitesImmunoblottingImplantIn VitroInflammatoryIntegrinsIonic StrengthsKineticsLeucine ZippersLife ExpectancyLigandsLightMechanicsMediatingMediator of activation proteinMesenchymalMethodologyMethodsMineralsModelingMolecular StructureMorphologyNatural regenerationNatureNoduleNorthern BlottingNude RatsNumbersOrgan TransplantationOrthopedicsOsteoblastsOsteocalcinOsteogenesisOsteoidPeptidesPerformancePersonal SatisfactionPhysiologicalPlayPopulationPorosityProcessPropertyProteinsRGD (sequence)RattusResolutionReverse Transcriptase Polymerase Chain ReactionRoleRouteScanning Electron MicroscopyScanning Transmission Electron Microscopy ProceduresSignal PathwaySignal TransductionSkeletal systemSpatial DistributionStaining methodStainsTechniquesTemperatureTestingTextureTimeTissue EngineeringTissuesTooth structureTransmission Electron MicroscopyTraumaTrichrome stainWeekWound Healingbasebiomaterial compatibilitybiomaterial developmentbiomineralizationbonebone sialoproteinbone strengthdensitydentin matrix protein 1designextracellularimplantationin vivolight scatteringmineralizationnanoindentationnanomaterialsnovelnovel strategiespolypeptideprotein aminoacid sequencereceptorrepairedresearch studyresponserestorationscaffoldself assemblysubcutaneousthree dimensional structuretissue regeneration
项目摘要
DESCRIPTION (provided by applicant): Biomineralization processes such as formation of bones and teeth require controlled mineral deposition and self-assembly into hierarchical biocomposites with unique mechanical properties. Ideal biomaterials for regeneration and repair of intramembranous and endochondral bone must be biocompatible, an optimal template for vascular invasion, facilitate normal differentiation of osteoprogenitor cells, ideal for deposition of mineral and possess intrinsic biocompatible properties. Novel methods of designing tissue repair and restoration materials using bioinspired strategies are currently in vogue. Therefore, it is possible that hierarchically organized nanomaterials can be constructed by tailor-made peptide sequences with self-assembling properties. Our overall goal is to employ novel strategies for fabrication of biomaterial for bone repair with a three-dimensional microstructure, by incorporating peptides with self-assembly characteristics along with spatial presentation of bioactive ligands that would provide a physiological environment for cells, facilitating proliferation, differentiation and inducing mineralized tissue formation.
Specifically we will:
(1) Design and fabricate self-assembled matrices that contain motifs for self-assembly, cell-adhesion and mineral induction;
(2) Test the functionality's of the motifs incorporated in the scaffold
(3) Test the osteogenic activity of the scaffold in vivo.
描述(由申请人提供):生物矿化过程,例如骨骼和牙齿的形成,需要受控的矿物质沉积和自组装成具有独特机械性能的分层生物复合材料。用于膜内骨和软骨内骨再生和修复的理想生物材料必须具有生物相容性,是血管侵袭的最佳模板,促进骨祖细胞的正常分化,是矿物质沉积的理想选择,并具有内在的生物相容性。使用仿生策略设计组织修复和修复材料的新方法目前很流行。因此,可以通过具有自组装特性的定制肽序列来构建分层组织的纳米材料。我们的总体目标是采用新颖的策略来制造具有三维微结构的骨修复生物材料,通过结合具有自组装特性的肽以及生物活性配体的空间呈现,为细胞提供生理环境,促进增殖、分化并诱导矿化组织形成。
具体来说,我们将:
(1) 设计和制造包含自组装、细胞粘附和矿物质诱导图案的自组装基质;
(2) 测试支架中纳入的基序的功能
(3)测试支架的体内成骨活性。
项目成果
期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Extracellular matrix of dental pulp stem cells: applications in pulp tissue engineering using somatic MSCs.
牙髓干细胞的细胞外基质:使用体细胞MSC在纸浆组织工程中的应用。
- DOI:10.3389/fphys.2013.00395
- 发表时间:2014-01-06
- 期刊:
- 影响因子:4
- 作者:Ravindran S;Huang CC;George A
- 通讯作者:George A
Biological assemblies provide novel templates for the synthesis of hierarchical structures and facilitate cell adhesion.
- DOI:10.1002/adfm.200801215
- 发表时间:2008-12-22
- 期刊:
- 影响因子:19
- 作者:Gajjeraman, Sivakumar;He, Gen;Narayanan, Karthikeyan;George, Anne
- 通讯作者:George, Anne
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Anne George其他文献
Anne George的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Anne George', 18)}}的其他基金
Role of DMP1 Mediated Paracrine Signaling in Vasculogenesis
DMP1 介导的旁分泌信号在血管生成中的作用
- 批准号:
10707373 - 财政年份:2022
- 资助金额:
$ 30.9万 - 项目类别:
Role of DMP1 Mediated Paracrine Signaling in Vasculogenesis
DMP1 介导的旁分泌信号在血管生成中的作用
- 批准号:
10587230 - 财政年份:2022
- 资助金额:
$ 30.9万 - 项目类别:
The Role of DPP in Dental Pulp Stem Cells and its Potential in Tissue Regeneration
DPP 在牙髓干细胞中的作用及其在组织再生中的潜力
- 批准号:
10372969 - 财政年份:2019
- 资助金额:
$ 30.9万 - 项目类别:
The Role of DPP in Dental Pulp Stem Cells and its Potential in Tissue Regeneration
DPP 在牙髓干细胞中的作用及其在组织再生中的潜力
- 批准号:
9890927 - 财政年份:2019
- 资助金额:
$ 30.9万 - 项目类别:
The Role of DPP in Dental Pulp Stem Cells and its Potential in Tissue Regeneration
DPP 在牙髓干细胞中的作用及其在组织再生中的潜力
- 批准号:
10596123 - 财政年份:2019
- 资助金额:
$ 30.9万 - 项目类别:
The Role of DPP in Dental Pulp Stem Cells and its Potential in Tissue Regeneration
DPP 在牙髓干细胞中的作用及其在组织再生中的潜力
- 批准号:
10133458 - 财政年份:2019
- 资助金额:
$ 30.9万 - 项目类别:
Intracellular and Extracellular function of dentin phosphophoryn
牙本质磷酸蛋白的细胞内和细胞外功能
- 批准号:
8465207 - 财政年份:2010
- 资助金额:
$ 30.9万 - 项目类别:
Intracellular and Extracellular function of dentin phosphophoryn
牙本质磷酸蛋白的细胞内和细胞外功能
- 批准号:
8269568 - 财政年份:2010
- 资助金额:
$ 30.9万 - 项目类别:
Intracellular and Extracellular function of dentin phosphophoryn
牙本质磷酸蛋白的细胞内和细胞外功能
- 批准号:
8089541 - 财政年份:2010
- 资助金额:
$ 30.9万 - 项目类别:
相似海外基金
I-Corps: Translation Potential of Peptidic Ensembles as Novel Bio-adhesives
I-Corps:肽整体作为新型生物粘合剂的转化潜力
- 批准号:
2409620 - 财政年份:2024
- 资助金额:
$ 30.9万 - 项目类别:
Standard Grant
Architectural design of active adhesives
活性粘合剂的结构设计
- 批准号:
2403716 - 财政年份:2024
- 资助金额:
$ 30.9万 - 项目类别:
Standard Grant
Design of non-swellable adhesives for brain surgery using cyclodextrin inclusion polymer
使用环糊精包合物聚合物脑外科不可溶胀粘合剂的设计
- 批准号:
23H01718 - 财政年份:2023
- 资助金额:
$ 30.9万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Meta-material adhesives for improved performance and functionalisation of bondlines
超材料粘合剂可提高粘合层的性能和功能化
- 批准号:
EP/W019450/1 - 财政年份:2023
- 资助金额:
$ 30.9万 - 项目类别:
Fellowship
Light-propelled dental adhesives with enhanced bonding capability
具有增强粘合能力的光驱动牙科粘合剂
- 批准号:
10741660 - 财政年份:2023
- 资助金额:
$ 30.9万 - 项目类别:
DMREF: Accelerating the Design of Adhesives with Nanoscale Control of Thermomechanical Properties
DMREF:通过热机械性能的纳米级控制加速粘合剂的设计
- 批准号:
2323317 - 财政年份:2023
- 资助金额:
$ 30.9万 - 项目类别:
Continuing Grant
Mag-Cure: A novel method for magnetically induced bonding and de-bonding of thermoset adhesives in the Automotive Industry
Mag-Cure:汽车行业中热固性粘合剂磁感应粘合和脱粘的新方法
- 批准号:
10062336 - 财政年份:2023
- 资助金额:
$ 30.9万 - 项目类别:
Collaborative R&D
Biodegradable, Biocompatible Pressure Sensitive Adhesives
可生物降解、生物相容性压敏粘合剂
- 批准号:
10677869 - 财政年份:2022
- 资助金额:
$ 30.9万 - 项目类别:
Poly(glycerol carbonate) pressure sensitive adhesives for the in vivo closure of alveolar pleural fistulae
用于体内闭合肺泡胸膜瘘的聚(甘油碳酸酯)压敏粘合剂
- 批准号:
10746743 - 财政年份:2022
- 资助金额:
$ 30.9万 - 项目类别:
Enhanced bio-production of difficult to make peptide ingredients for specialty adhesives and personal care
增强用于特种粘合剂和个人护理品的难以制造的肽成分的生物生产
- 批准号:
10021363 - 财政年份:2022
- 资助金额:
$ 30.9万 - 项目类别:
Investment Accelerator