Synaptic mechanisms of touch processing in Drosophila
Synaptic mechanisms of touch processing in Drosophila
批准号:
8782828
负责人:
John Tuthill
金额:
$5.33万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2014
资助国家:
美国
项目状态:
已结题
起止时间:
2014-07-01 至 2017-06-30
关键词:
Action PotentialsAddressAmericanAnimal ModelAxonBehaviorBody SurfaceCNS processingCellsCharacteristicsCodeComplexDeep Brain StimulationDiseaseDrosophila genusDrosophila melanogasterElectrophysiology (science)ExhibitsFrequenciesGABA ReceptorGeneticGenetic ModelsGenetic ScreeningGroomingHumanIndividualInvestigationIon ChannelLabelLeadLegMammalsMapsMeasuresMechanicsMechanoreceptorsMedicalMotionMovementNervous system structureNeuraxisNeuronsOrganPatternPeripheralPeripheral Nervous SystemPhasePopulationProcessPropertyReflex actionSensorySignal TransductionSkinStimulusSurfaceSynapsesSystemTactileTestingThalamic structureTherapeutic InterventionTimeTouch sensationUnconscious Statechronic painexperienceflyin vivoneuromechanismpainful neuropathypatch clamppublic health relevancereceptive fieldreceptorrelating to nervous systemresearch studyresponsesensory stimulus
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英文摘要
DESCRIPTION (provided by applicant): The sense of touch is critical for interacting with the physical world. In order to respond to complex tactile stimuli, the nervous system must integrate patterns of spikes across populations of primary mechanoreceptor neurons. However, the mechanisms used by the nervous system to detect complex mechanical stimuli are not known. In order to understand how the central nervous system processes peripheral mechanosensory information, I propose to study the central coding of touch in the genetic model organism, Drosophila. As in mammals, the fly's body surface is covered with primary mechanosensory organs. Among these mechanoreceptors, the tactile bristles are particularly amenable to investigation because they can be stimulated independently of each other and are sufficient to drive postural reflexes and grooming behavior. Little is known, however, about the neural coding of touch stimuli within bristles or in downstream circuits. I will perform experiments to address two specific questions: 1) what classes of central neurons integrate signals from mechanosensory bristles and 2) how do these central neurons process their inputs to detect specific patterns of bristle stimulation? To answer the first question, I will screen genetic drive lines for central neurons that receive direct input from mechanosensory bristles. I will then use whole-cell patch-clamp electrophysiology to investigate specific mechanisms of spatial and temporal integration. By tracing the flow of sensory signals from primary receptor neurons to synaptic integration in the central nervous system, I hope to identify fundamental mechanisms of neural coding that are highly relevant for central disorders of mechanosensory processing in humans, such as chronic pain and itch.
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Dissecting circuit and cellular mechanisms for limb motor control
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批准号:10522108
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项目类别:
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资助金额:$107.19万
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财政年份:2022
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负责人:John Tuthill
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依托单位:
Neural coding of leg proprioception
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批准号:9361774
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项目类别:
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资助金额:$33.91万
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财政年份:2017
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负责人:John Tuthill
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依托单位:
Neural coding of leg proprioception
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批准号:10624896
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项目类别:
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资助金额:$38.55万
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财政年份:2017
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负责人:John Tuthill
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依托单位:
Project 1: Neural Basis of Muscle Action Loops
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批准号:10202761
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项目类别:
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资助金额:$65.91万
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财政年份:2017
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负责人:John Tuthill
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依托单位:
Neural coding of leg proprioception
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批准号:10200156
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项目类别:
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资助金额:$34.02万
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财政年份:2017
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负责人:John Tuthill
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依托单位:
Project 1: Neural Basis of Muscle Action Loops
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批准号:9444305
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项目类别:
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资助金额:$65.17万
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财政年份:--
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负责人:John Tuthill
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依托单位:
海外基金