Dissecting circuit and cellular mechanisms for limb motor control
剖析肢体运动控制的电路和细胞机制
基本信息
- 批准号:10522108
- 负责人:
- 金额:$ 107.19万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-08-17 至 2025-07-31
- 项目状态:未结题
- 来源:
- 关键词:Action PotentialsAddressAlgorithmsAnimalsArchitectureBehaviorBehavioralBehavioral ParadigmBiological ModelsBrainComplexDataDrosophila genusDrosophila melanogasterElectron MicroscopyElectrophysiology (science)EngineeringEquipment and supply inventoriesExhibitsFeedbackFemurFire - disastersFlexorFoundationsGeneticGoalsInterneuronsInterventionInvestigationJointsLabelLeadLearningLegLimb structureLocomotionMeasurementMeasuresMechanicsModelingMotorMotor NeuronsMotor outputMovementMuscleMuscle ContractionNervous System PhysiologyNervous system structureNeuraxisNeuromuscular DiseasesNeuronsOutputPatternPhysiologyPopulationPositioning AttributePostureProductionPropertyProprioceptorReflex actionRoleSignal TransductionSpinalSpinal CordSpinal InjuriesStimulusStructureSynapsesSystemTestingTranslatingUpdateVertebratesWorkbasecell typeexhaustionflexibilityflyin vivoinsightlimb movementmotor controlmotor neuron functionneural circuitneural modelneural patterningneuroregulationnoveloptogeneticspresynaptic neuronsreconstructionrecruitrelating to nervous systemsensory feedbacktherapy designtibiatool
项目摘要
Motor neurons connect to muscles and comprise the major output of the nervous system. Patterns of
neural activity in motor neurons cause temporally precise muscle contractions, producing coordinated
and flexible behavior. These patterns are shaped by the connectivity and physiology of premotor circuits
in the spinal cord that synapse onto the motor neurons. Premotor circuits combine descending motor
commands with sensory feedback signals to drive motor neuron activity. How premotor networks are
structured to control motor output is not well understood, due in part to an incomplete inventory of spinal
cell types, and to the difficulties of recording neural activity in behaving animals. To address this gap, this
project aims to use Drosophila melanogaster as a model for investigating motor control and premotor
neural circuits. With an accessible and numerically compact nervous system, a large and growing suite
of genetic tools, and agile, limbed locomotion, Drosophila has the potential to provide insight into
fundamental problems of motor control. We introduce a task in which flies learn to generate specific
amounts of force to position the femur-tibia joint in different targets. The joint is controlled by twelve
neurons which can be genetically labeled for targeted neural recordings. Electrophysiological recordings
will reveal how the complete population of motor neurons function together to dynamically position the
leg and to sustain a given force output. These data will address long-standing hypotheses about how
premotor circuits recruit subsets of motor neurons and the degree to which that control is flexible. Then,
a new electron-microscopy level reconstruction of central locomotor circuits will allow identification of key
premotor neurons. Electrophysiological recordings of those premotor neurons during the behavioral task
will reveal their contributions to processing sensory feedback and to controlling leg force. These results
will provide a foundation for understanding how descending commands interact with internal models of
body state to control locomotion, a critical step toward achieving the long-term goals of designing
interventions for neuromuscular disorders and algorithms for controlling engineered systems.
运动神经元连接肌肉,构成神经系统的主要输出。的模式
项目成果
期刊论文数量(0)
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John Tuthill其他文献
John Tuthill的其他文献
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{{ truncateString('John Tuthill', 18)}}的其他基金
Project 1: Neural Basis of Muscle Action Loops
项目 1:肌肉动作环的神经基础
- 批准号:
10202761 - 财政年份:2017
- 资助金额:
$ 107.19万 - 项目类别:
Synaptic mechanisms of touch processing in Drosophila
果蝇触觉处理的突触机制
- 批准号:
8782828 - 财政年份:2014
- 资助金额:
$ 107.19万 - 项目类别:
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