Project 1: Neural Basis of Muscle Action Loops

项目1：肌肉动作回路的神经基础 摘要 项目1的目标是确定低水平感觉运动加工的神经机制， 控制行走和飞行行为的肌肉动作回路。作用于 神经系统和身体，肌肉行动循环面临着一系列令人生畏的要求：他们必须运作， 速度和精度，同时保持必要的灵活性和鲁棒性， 多样的、不可预测的环境。了解电机控制电路如何平衡这些需求 为了控制适应性行为，我们将联合收割机细胞类型特异性遗传工具与电生理学相结合， 功能成像和行为分析。我们将首先研究内部的活动 不同的运动神经元群体相互作用，产生肌肉收缩和复杂的身体 动作然后，我们将询问本体感受反馈信号如何与持续的运动整合， 命令来调整和优化行为输出。最后，我们将努力了解如何低水平 肌肉动作环与下行神经调节信号相互作用，产生模式化运动 活动这些实验和理论工作分为以下具体目标： 具体目标1：研究运动神经元如何鲁棒地控制身体运动。 具体目标2：确定本体感受反馈在微调精确 电机输出 具体目标3：确定感觉运动神经调节的起源和机制， 有助于灵活的运动行为。

Project 1: The Neural Basis of Muscle Action Loops Abstract The goal of Project 1 is to identify neural mechanisms of sensorimotor processing within low-level muscle action loops that control walking and flight behavior. Acting at the interface between the nervous system and the body, muscle action loops face a daunting set of demands: they must operate with both speed and precision, while retaining the flexibility and robustness necessary to function in diverse, unpredictable environments. To understand how motor control circuits balance these demands to control adaptive behavior, we will combine cell-type specific genetic tools with electrophysiology, functional imaging, and behavioral analysis in the fly. We will first investigate how activity within diverse populations of motor neurons interacts to produce muscle contraction and complex body movements. We will then ask how proprioceptive feedback signals are integrated with ongoing motor commands to adapt and refine behavioral output. Finally, we will work to understand how low-level muscle action loops interact with descending neuromodulatory signals to generate patterned motor activity. These experimental and theoretical efforts are divided into the following Specific Aims: Specific Aim 1: Investigate how motor neurons robustly control body movement. Specific Aim 2: Determine the role of proprioceptive feedback in fine-tuning precise motor output. Specific Aim 3: Identify origins and mechanisms of sensorimotor neuromodulation that contribute to flexible locomotor behavior.