Project 1: Neural Basis of Muscle Action Loops

项目 1：肌肉动作环的神经基础

• 批准号: 9444305
• 负责人: John Tuthill
• 金额: $ 65.17万
• 依托单位: CALIFORNIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9444305
• 关键词: Action Potentials; Adaptive Behaviors; Affect; Afferent Neurons; Animals; Architecture; Axon; Back; Behavior; Behavioral; Brain; Breathing; Complex; Dancing; Dendrites; Electrophysiology (science); Elements; Environment; Equilibrium; Face; Feedback; Functional Imaging; Gait; Genetic; Goals; Grasshoppers; Human; Insecta; Internet; Invertebrates; Lead; Leg; Maps; Mechanics; Motor; Motor Activity; Motor Neurons; Motor output; Movement; Muscle; Muscle Cells; Muscle Contraction; Nervous system structure; Neurons; Output; Pathway interactions; Pattern; Population; Population Heterogeneity; Proprioceptor; Role; Running; Sensory; Signal Transduction; Songbirds; Speed; Synapses; Testing; Time; Vertebrates; Walking; Wing; Work; cell type; flexibility; fly; motor control; motor neuron function; neuromechanism; neuroregulation; programs; relating to nervous system; sensory feedback; tool

Project 1: The Neural Basis of Muscle Action Loops Abstract The goal of Project 1 is to identify neural mechanisms of sensorimotor processing within low-level muscle action loops that control walking and flight behavior. Acting at the interface between the nervous system and the body, muscle action loops face a daunting set of demands: they must operate with both speed and precision, while retaining the flexibility and robustness necessary to function in diverse, unpredictable environments. To understand how motor control circuits balance these demands to control adaptive behavior, we will combine cell-type specific genetic tools with electrophysiology, functional imaging, and behavioral analysis in the fly. We will first investigate how activity within diverse populations of motor neurons interacts to produce muscle contraction and complex body movements. We will then ask how proprioceptive feedback signals are integrated with ongoing motor commands to adapt and refine behavioral output. Finally, we will work to understand how low-level muscle action loops interact with descending neuromodulatory signals to generate patterned motor activity. These experimental and theoretical efforts are divided into the following Specific Aims: Specific Aim 1: Investigate how motor neurons robustly control body movement. Specific Aim 2: Determine the role of proprioceptive feedback in fine-tuning precise motor output. Specific Aim 3: Identify origins and mechanisms of sensorimotor neuromodulation that contribute to flexible locomotor behavior.

项目1：肌肉动作环的神经基础 摘要 项目1的目标是确定低水平感觉运动加工的神经机制。 控制行走和飞行行为的肌肉动作环。在两个对象之间的界面上起作用 神经系统和身体，肌肉动作环面临着一系列令人望而生畏的要求：它们必须 既有速度又有精度，同时还保留了在 多样化的、不可预测的环境。要了解电机控制电路如何平衡这些需求 为了控制适应行为，我们将结合细胞类型特定的遗传工具和电生理学， 功能成像和飞行中的行为分析。我们将首先调查内部活动是如何 不同群体的运动神经元相互作用，产生肌肉收缩和复杂的身体 动静。然后我们会问本体感觉反馈信号是如何与正在进行的运动整合的 调整和优化行为输出的命令。最后，我们将努力了解低级别 肌肉动作环与下行的神经调节信号相互作用，产生模式运动 活动。这些实验和理论工作分为以下具体目标： 具体目标1：研究运动神经元如何强健地控制身体运动。 具体目标2：确定本体感觉反馈在微调精确度中的作用 马达输出。 具体目标3：确定感觉运动神经调节的起源和机制 有助于灵活的运动行为。