2014 Post-Transcriptional Gene Regulation Gordon Research Conference & Gordon Res

2014年转录后基因调控戈登研究会议

基本信息

  • 批准号:
    8785727
  • 负责人:
  • 金额:
    $ 1万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2014
  • 资助国家:
    美国
  • 起止时间:
    2014-07-16 至 2015-07-15
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The 2014 Gordon Research Conference (GRC) on Post-Transcriptional Gene Regulation will be the sixth in a biennial series that began in 2004. This year's meeting will be held July 13-18 at Salve Regina University in Newport, RI, and will be accompanied by a Gordon Research Seminar (GRS) on July 12-13. This GRC and GRS provide outstanding forums to present and discuss new findings about the mediation and regulation of RNA metabolism in normal and diseased states, and how such processes can be targeted and/or harnessed to treat human disease. Elucidating the basic mechanisms of post-transcriptional gene regulation is essential to fully understand the organization, evolution and function of present-day genomes, as well as the involvement of RNA metabolic dysfunction in numerous genetic and acquired disorders. Such fundamental knowledge underpins development of novel therapeutics based on or targeting specific post-transcriptional processes. Areas of emphasis at this year's meeting will include RNA evolution, RNA processing, editing and nucleotide modification, RNA-protein (RNP) complex assembly and dynamics, intra- and extra-cellular RNP transport, mRNA translation and decay, the functions of long and short non-coding RNAs, RNA toxicity, the contributions of abnormal RNA metabolism to congenital and neurodegenerative diseases, and novel therapeutic avenues arising from our ever-increasing understanding of post-transcriptional mechanisms. A key goal of the 2014 meeting is to increase interaction between academic and industrial scientists for their mutual benefit and to facilitate development of novel therapeutics. With this in mind, a significant proportion of this year's speakers come from companies working in this rapidly evolving therapeutic space. The GRC will convene approximately 45 speakers representing key areas of post-transcriptional gene regulation and therapeutic development, with a total of 160-200 participants from both academia and industry. Several short talks will be chosen from abstract submissions. Late afternoon poster sessions will enable all participants to contribute to and learn about the above-mentioned topics. Four top posters will be acknowledged: two graduate students' and two post-docs'. All participants will also interact at meal times and during free early afternoon and late evening periods. While the quality of science will be cutting-edge, the atmosphere is aimed at being relaxed and interactive. For early stage investigators, there will also be a two- day GRS immediately prior to the GRC; the GRS will provide an opportunity for these young scientists to both hone their speaking skills and to become comfortable participating in a high level scientific conference. For graduate students and postdocs interested in pursuing a career in industry, the GRS will include a panel discussion with industry leaders and early stage industry researchers.
描述(由申请人提供):2014年戈登转录后基因调控研究会议(GRC)将是2004年开始的两年一次的系列会议中的第六届会议。今年的会议将于7月13日至18日在罗德岛新港的萨尔维里贾纳大学举行,并将于7月12日至13日举行戈登研究研讨会(GRS)。本次GRC和GRS提供了出色的论坛来展示和讨论关于正常和患病状态下RNA代谢的调解和调节的新发现,以及如何靶向和/或利用这些过程来治疗人类疾病。阐明转录后基因调控的基本机制对于全面了解当今基因组的组织、进化和功能,以及RNA代谢功能障碍在许多遗传和获得性疾病中的作用至关重要。这些基础知识支持了基于或靶向特定转录后过程的新疗法的发展。今年会议的重点领域将包括RNA进化、RNA加工、编辑和核苷酸修饰、RNA-蛋白(RNP)复合物组装和动力学、细胞内和细胞外RNP转运、mRNA翻译和衰变、长链和短链非编码RNA的功能、RNA毒性、异常RNA代谢对先天性和神经退行性疾病的贡献。以及我们对转录后机制不断加深的理解所产生的新的治疗途径。2014年会议的一个关键目标是增加学术和工业科学家之间的互动,以实现他们的共同利益,并促进新疗法的发展。考虑到这一点,今年的演讲者中有很大一部分来自这个快速发展的治疗领域的公司。GRC将召集大约45位代表转录后基因调控和治疗发展关键领域的演讲者,来自学术界和工业界的参与者共计160-200人。将从提交的摘要中选择几个简短的演讲。下午晚些时候的海报会议将使所有与会者能够为上述主题做出贡献并了解上述主题。四名优秀的海报将被认可:两名研究生和两名博士后。所有参与者还将在用餐时间、下午早些时候和晚上的自由时间进行互动。虽然科学的质量将是尖端的,但气氛旨在轻松和互动。对于早期调查人员,在GRC之前也会有一个为期两天的GRS;GRS将为这些年轻科学家提供一个机会,既磨练他们的演讲技巧,又适应参加高水平的科学会议。对于有意投身工业领域的研究生和博士后,GRS将包括与行业领袖和早期行业研究人员的小组讨论。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Melissa J. Moore其他文献

Direct Observation of pre-mRNA Arrangements During Spliceosome Assembly Using Single Molecule FRET
  • DOI:
    10.1016/j.bpj.2010.12.1488
  • 发表时间:
    2011-02-02
  • 期刊:
  • 影响因子:
  • 作者:
    Daniel J. Crawford;Larry J. Friedman;Aaron A. Hoskins;Jeff Gelles;Melissa J. Moore
  • 通讯作者:
    Melissa J. Moore
Dynamic and Ordered Assembly of Single Spliceosomes
  • DOI:
    10.1016/j.bpj.2010.12.1487
  • 发表时间:
    2011-02-02
  • 期刊:
  • 影响因子:
  • 作者:
    Aaron Hoskins;Larry Friedman;Sarah S. Gallagher;Daniel J. Crawford;Eric G. Anderson;Richard Wombacher;Nicholas Ramirez;Virginia W. Cornish;Jeff Gelles;Melissa J. Moore
  • 通讯作者:
    Melissa J. Moore
Evidence for two active sites in the spliceosome provided by stereochemistry of pre-mRNA splicing
前体 mRNA 剪接的立体化学提供了剪接体中有两个活性位点的证据
  • DOI:
    10.1038/365364a0
  • 发表时间:
    1993-09-23
  • 期刊:
  • 影响因子:
    48.500
  • 作者:
    Melissa J. Moore;Phillip A. Sharp
  • 通讯作者:
    Phillip A. Sharp
Turning on the Spliceosome
  • DOI:
    10.1016/j.bpj.2011.11.3278
  • 发表时间:
    2012-01-31
  • 期刊:
  • 影响因子:
  • 作者:
    Aaron Hoskins;Larry Friedman;Ivan Correa;Ming-Qun Xu;Virginia W. Cornish;Jeff Gelles;Melissa J. Moore
  • 通讯作者:
    Melissa J. Moore
Into the CoSMoS: Single Molecule Analysis of Spliceosome Assembly and Activation
  • DOI:
    10.1016/j.bpj.2011.11.3324
  • 发表时间:
    2012-01-31
  • 期刊:
  • 影响因子:
  • 作者:
    Aaron A. Hoskins;Larry J. Friedman;Daniel J. Crawford;Eric J. Anderson;Inna Shcherbakova;Virginia W. Cornish;Jeff Gelles;Melissa J. Moore
  • 通讯作者:
    Melissa J. Moore

Melissa J. Moore的其他文献

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{{ truncateString('Melissa J. Moore', 18)}}的其他基金

MALDI-TOF MASS SPECTROMETER
MALDI-TOF 质谱仪
  • 批准号:
    2503124
  • 财政年份:
    1998
  • 资助金额:
    $ 1万
  • 项目类别:
DIVISION OF MOLECULAR AND CELLULAR MECHANISMS
分子和细胞机制的划分
  • 批准号:
    7061556
  • 财政年份:
    1997
  • 资助金额:
    $ 1万
  • 项目类别:
DIVISION OF MOLECULAR AND CELLULAR MECHANISMS
分子和细胞机制的划分
  • 批准号:
    7000005
  • 财政年份:
    1997
  • 资助金额:
    $ 1万
  • 项目类别:
DIVISION OF MOLECULAR AND CELLULAR MECHANISMS
分子和细胞机制的划分
  • 批准号:
    7124519
  • 财政年份:
    1997
  • 资助金额:
    $ 1万
  • 项目类别:
DIVISION OF MOLECULAR AND CELLULAR MECHANISMS
分子和细胞机制的划分
  • 批准号:
    7035481
  • 财政年份:
    1997
  • 资助金额:
    $ 1万
  • 项目类别:
DIVISION OF MOLECULAR AND CELLULAR MECHANISMS
分子和细胞机制的划分
  • 批准号:
    6950129
  • 财政年份:
    1997
  • 资助金额:
    $ 1万
  • 项目类别:
EXON LIGATION--THE SPLICEOSOME AND GROUP 11 INTRONS
外显子连接——剪接体和第11组内含子
  • 批准号:
    2459644
  • 财政年份:
    1995
  • 资助金额:
    $ 1万
  • 项目类别:
Pre-mRNA Splicing Mechanisms
前体 mRNA 剪接机制
  • 批准号:
    8399727
  • 财政年份:
    1995
  • 资助金额:
    $ 1万
  • 项目类别:
Pre-mRNA Splicing Mechanisms
前体 mRNA 剪接机制
  • 批准号:
    9061691
  • 财政年份:
    1995
  • 资助金额:
    $ 1万
  • 项目类别:
Mammalian Pre-mRNA Splicing Mechanisms
哺乳动物前体 mRNA 剪接机制
  • 批准号:
    7100605
  • 财政年份:
    1995
  • 资助金额:
    $ 1万
  • 项目类别:

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