2014 Post-Transcriptional Gene Regulation Gordon Research Conference & Gordon Res

描述（由申请人提供）：2014年戈登转录后基因调控研究会议（GRC）将是2004年开始的两年一次的系列会议中的第六次。今年的会议将于7月13日至18日在纽波特的Salve Regina大学举行，并将于7月12日至13日举行戈登研究研讨会（GRS）。该GRC和GRS提供了出色的论坛，以展示和讨论有关正常和疾病状态下RNA代谢的介导和调节的新发现，以及如何靶向和/或利用这些过程来治疗人类疾病。阐明转录后基因调控的基本机制对于充分理解当今基因组的组织、进化和功能以及RNA代谢功能障碍在许多遗传和获得性疾病中的参与至关重要。这些基础知识支持基于或靶向特定转录后过程的新型疗法的开发。今年会议的重点领域将包括RNA进化，RNA加工，编辑和核苷酸修饰，RNA-蛋白质（RNP）复合物组装和动力学，细胞内和细胞外RNP运输，mRNA翻译和衰变，长和短非编码RNA的功能，RNA毒性，异常RNA代谢对先天性和神经退行性疾病的贡献，和新的治疗途径，从我们不断增加的理解转录后机制。2014年会议的一个关键目标是增加学术界和工业界科学家之间的互动，以实现互利，并促进新疗法的开发。考虑到这一点，今年的演讲者中有很大一部分来自这个快速发展的治疗领域的公司。GRC将召集约45位演讲者，代表转录后基因调控和治疗开发的关键领域，共有来自学术界和工业界的160-200名参与者。将从提交的摘要中选择几个简短的演讲。下午晚些时候的海报会议将使所有与会者能够对上述专题作出贡献并了解这些专题。四个顶级海报将得到承认：两个研究生和两个博士后。所有参与者还将在用餐时间以及下午早些时候和晚上的免费时段进行互动。虽然科学的质量将是尖端的，但气氛旨在放松和互动。对于早期研究人员，在GRC之前还将有一个为期两天的GRS; GRS将为这些年轻科学家提供一个机会，磨练他们的演讲技巧，并在参加高级别科学会议时感到舒适。对于有兴趣从事工业职业的研究生和博士后，GRS将包括与行业领导者和早期行业研究人员的小组讨论。

DESCRIPTION (provided by applicant): The 2014 Gordon Research Conference (GRC) on Post-Transcriptional Gene Regulation will be the sixth in a biennial series that began in 2004. This year's meeting will be held July 13-18 at Salve Regina University in Newport, RI, and will be accompanied by a Gordon Research Seminar (GRS) on July 12-13. This GRC and GRS provide outstanding forums to present and discuss new findings about the mediation and regulation of RNA metabolism in normal and diseased states, and how such processes can be targeted and/or harnessed to treat human disease. Elucidating the basic mechanisms of post-transcriptional gene regulation is essential to fully understand the organization, evolution and function of present-day genomes, as well as the involvement of RNA metabolic dysfunction in numerous genetic and acquired disorders. Such fundamental knowledge underpins development of novel therapeutics based on or targeting specific post-transcriptional processes. Areas of emphasis at this year's meeting will include RNA evolution, RNA processing, editing and nucleotide modification, RNA-protein (RNP) complex assembly and dynamics, intra- and extra-cellular RNP transport, mRNA translation and decay, the functions of long and short non-coding RNAs, RNA toxicity, the contributions of abnormal RNA metabolism to congenital and neurodegenerative diseases, and novel therapeutic avenues arising from our ever-increasing understanding of post-transcriptional mechanisms. A key goal of the 2014 meeting is to increase interaction between academic and industrial scientists for their mutual benefit and to facilitate development of novel therapeutics. With this in mind, a significant proportion of this year's speakers come from companies working in this rapidly evolving therapeutic space. The GRC will convene approximately 45 speakers representing key areas of post-transcriptional gene regulation and therapeutic development, with a total of 160-200 participants from both academia and industry. Several short talks will be chosen from abstract submissions. Late afternoon poster sessions will enable all participants to contribute to and learn about the above-mentioned topics. Four top posters will be acknowledged: two graduate students' and two post-docs'. All participants will also interact at meal times and during free early afternoon and late evening periods. While the quality of science will be cutting-edge, the atmosphere is aimed at being relaxed and interactive. For early stage investigators, there will also be a two- day GRS immediately prior to the GRC; the GRS will provide an opportunity for these young scientists to both hone their speaking skills and to become comfortable participating in a high level scientific conference. For graduate students and postdocs interested in pursuing a career in industry, the GRS will include a panel discussion with industry leaders and early stage industry researchers.