P30 - Core Grant for Vision Research

项目总结 NEI中心视觉研究核心助学金申请的广泛目标是促进学习 关于视觉系统在健康和致盲疾病中的结构、发育和功能，目的是 预防、减轻或治愈此类疾病，或恢复失明，通过应用 最复杂的可用技术。四个资源和服务核心将有助于实现广泛的 目标，具体如下： 图像分析和图形核心：形态测量分析；计算机辅助图像分析； 制作用于数据分析、演示和发布的图形 形态核心：组织学(石蜡和塑料包埋、切片和染色、冰冻 免疫组织化学切片)、眼部成像(裂隙灯检查和摄影，Micron III 眼底照相(使用荧光素血管造影术)和光学相干断层扫描(OCT)，生物测定 Bioptigen OCT)和视觉功能测试(ERG、OptoMotry和IOP)以及啮齿类动物体内注射 电穿孔器安装好了。显微镜(光学显微镜.明场、暗场、位相对比度、DIC和 荧光)和显微照相术，以及使用旋转圆盘和 共焦显微镜)。 三.计算机/信息技术核心：为客户研究需要编制程序；协助计算机和 信息技术硬件和软件的选择、安装、使用说明、维护和次要 修理。 四.快速成型和设计核心：设计新的独特研究设备和教育 并对用户进行培训，使他们能够参与制造、施工、维护和 升级他们独特的研究设备设计。 这是一份NEI中心视力研究核心助学金的申请，由 首席研究员和其他19名视觉科学家，他们拥有23项有效的NEI R01研究资助。在……里面 此外，加州大学旧金山分校由NEI Vision Core Grant支持的视觉研究社区由14个NEI- 用活动R01以外的资助机制支持科学家，用NIH其他资金支持4名，用FDA R01支持1名 资金和5个私人资金。总体而言，有41名核心调查人员拥有积极的研究计划， 每个人至少使用一个中等或广泛级别的核心。使用传统和创新的方法， 这项核心愿景研究补助金非常成功，有助于提高生产力 和视觉研究的影响，吸引科学家进行视觉研究，并促进关于 加州大学旧金山分校的视觉系统。

PROJECT SUMMARY The broad objective of this NEI Center Core Grant for Vision Research application is to facilitate study of the structure, development and function of the visual system in health and in blinding diseases, with the aim of preventing, mitigating or curing such diseases, or the restoration of lost vision, through the application of the most sophisticated available techniques. Four resource and service Cores will help achieve the broad objective, as follows: I. Image Analysis and Graphics Core: Morphometric analysis; computer-aided image analysis; production of graphics for data analysis, presentation and publication II. Morphology Core: Histology (paraffin and plastic embedding, sectioning and staining, frozen sectioning for immunohistochemistry), ocular imaging (slit lamp examination and photography, Micron III fundus photography (with fluorescein angiography) and optical coherence tomography (OCT), biometric Bioptigen OCT) and visual functional testing (ERG, OptoMotry and IOP) and in vivo rodent eye injection with electroporator set up. Microscopy (light microscopy - brightfield, darkfield, phase contrast, DIC and fluorescence) and photomicrography, and advanced microscopy using a combination of spinning disk and confocal microscopes). III. Computer/IT Core: Programming for custom research needs; assistance in computer and information technology hardware and software selection, installation, instruction in use, maintenance and minor repairs. IV. Rapid-Prototyping and Design Core: Design of new unique research equipment plus education and training of users, empowering them to participate in the manufacturing, construction, maintenance, and upgrading of their unique research equipment designs. This is an application of a NEI Center Core Grant for Vision Research competing renewal submitted by the Principal Investigator and 19 other vision scientists who hold 23 active NEI R01 research grants. In addition, the UCSF vision research community supported by the NEI Vision Core Grant comprises 14 NEI- supported scientists with grant mechanisms other than active R01, 4 with other NIH funding, 1 with FDA R01 funding and 5 with private funding. There are 41 Core Investigators with active research programs, overall, each using at least one Core at a moderate or extensive level. Using traditional and innovative approaches, this Core Vision Research Grant has been highly successful and instrumental in enhancing the productivity and impact of vision research, attracting scientists to vision research and facilitating collaborative studies on the visual system at UCSF.