Training Program in Molecular, Cell, and Developmental Biology

分子、细胞和发育生物学培训项目

• 批准号: 9522000
• 负责人: Susan Strome
• 金额: $ 28.48万
• 依托单位: UNIVERSITY OF CALIFORNIA SANTA CRUZ
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9522000
• 关键词: Cellular biology; Developmental Biology; Molecular Biology; Training Programs

DESCRIPTION (provided by applicant): The goals of the UCSC Graduate Training Program in Molecular, Cell and Developmental Biology are to recruit highly motivated graduate students, provide them with critical thinking skills, expertise in experimental design and interpretation, an a strong framework of knowledge, while also amplifying their passion for inquiry and discovery. We strongly encourage interdisciplinary and collaborative research that crosses departmental, divisional, and even institutional boundaries. Intellectual, cultural, and socioeconomic diversity are prevalent in our graduate student population, and we constantly seek new approaches to attract and inspire students from under-represented groups. Our Training Program prepares students to pursue diverse careers in biomedical research, teaching, government, and industry. First-year trainees participate in three 6-week research rotations and in a core curriculum designed to train them in the logic of experimental analysis. Students learn how to evaluate published research, effectively argue scientific points, formulate hypotheses, design rigorous experiments, and write research manuscripts and proposals with intellectual depth. Students join a laboratory to pursue their Ph.D. thesis research in Spring of their first year. Second-year students train in the responsible conduct of research and take an oral qualifying exam. Third-year students present a full research seminar to the Training Program. Students at all stages participate in departmental seminars, research meetings, and journal clubs, and take advanced elective courses of their choosing. These broaden their training experience and promote interactions among trainees and faculty. Training culminates with a written Ph.D. dissertation and oral defense. Our Training Program includes 30 faculty from 5 departments, including the Departments of Molecular, Cell and Developmental Biology, Biomolecular Engineering, Chemistry and Biochemistry, Microbiology and Environmental Toxicology, and Physics. Participating laboratories are intermingled in 3 adjacent buildings on "science hill", which encourages interaction and collaboration. Research in the Training Program utilizes a wide variety of approaches, and is organized with interdisciplinary clusters of common interests (e.g. Cell Biology, Chromatin, Neurobiology, and RNA), thereby creating critical masses of researchers that foster mutual support and scientific creativity. Many training faculty work on systems that are directly relevant to human health, including stem cell biology, malaria, cholera, cancer biology, host-pathogen interactions, neurodegenerative diseases, and the responses of neurons to stroke and other damage. Other faculty carry out basic research that provides the foundation for understanding topics relevant to human health, including cell division, signaling, meiosis, chromatin organization, cell differentiation, and neurobiology. Our Training Grant, currently in its 14th year, supports 6 trainees. In this renewal, we are requesting support for 8 trainees. Training Grant positions will continue to be awarded to our most promising students.

描述（由申请人提供）：UCSC 分子、细胞和发育生物学研究生培训项目的目标是招募积极性高的研究生，为他们提供批判性思维技能、实验设计和解释方面的专业知识、强大的知识框架，同时增强他们对探究和发现的热情。我们强烈鼓励跨部门、部门甚至机构界限的跨学科和协作研究。知识、文化和社会经济的多样性在我们的研究生群体中普遍存在，我们不断寻求新的方法来吸引和激励来自弱势群体的学生。我们的培训计划帮助学生做好在生物医学研究、教学、政府和工业领域从事各种职业的准备。第一年的学员将参加三个为期 6 周的研究轮转，并参加旨在培训他们实验分析逻辑的核心课程。学生学习如何评估已发表的研究、有效论证科学观点、提出假设、设计严格的实验以及撰写具有知识深度的研究手稿和提案。学生加入实验室攻读博士学位。第一年春季的论文研究。二年级学生接受负责任的研究行为培训，并参加口语资格考试。三年级学生为培训计划举办了一次完整的研究研讨会。各个阶段的学生参加院系研讨会、研究会议和期刊俱乐部，并选修自己选择的高级选修课程。这些扩大了他们的培训经验并促进了学员和教师之间的互动。培训最终以书面博士学位形式结束。论文和口头答辩。我们的培训项目包括来自分子、细胞和发育生物学、生物分子工程、化学和生物化学、微生物学和环境毒理学以及物理等5个系的30名教师。参与实验室分布在“科学山”上的 3 座相邻建筑中，鼓励互动和协作。培训计划中的研究采用多种方法，并由具有共同兴趣的跨学科集群（例如细胞生物学、染色质、神经生物学和 RNA）组织起来，从而培养了关键的研究人员群体，促进相互支持和科学创造力。许多培训教师致力于与人类健康直接相关的系统，包括干细胞生物学、疟疾、霍乱、癌症生物学、宿主与病原体的相互作用、神经退行性疾病以及神经元对中风和其他损伤的反应。其他教师开展基础研究，为理解与人类健康相关的主题奠定基础，包括细胞分裂、信号传导、减数分裂、染色质组织、细胞分化和神经生物学。我们的培训补助金目前已进入第 14 个年头，为 6 名学员提供了支持。在本次更新中，我们请求为 8 名学员提供支持。培训补助金职位将继续授予我们最有前途的学生。

项目成果

Mutating two putative phosphorylation sites on ZHP-3 does not affect its localization or function during meiotic chromosome segregation.

• DOI: 10.17912/micropub.biology.000354
• 发表时间: 2021-01-18
• 期刊: microPublication biology
• 作者: Russo AE;Nelson CR;Bhalla N
• 通讯作者: Bhalla N

Genetic Models Reveal cis and trans Immune-Regulatory Activities for lincRNA-Cox2.

• DOI: 10.1016/j.celrep.2018.10.027
• 发表时间: 2018-11-06
• 期刊: Cell reports
• 影响因子: 8.8
• 作者: Elling R;Robinson EK;Shapleigh B;Liapis SC;Covarrubias S;Katzman S;Groff AF;Jiang Z;Agarwal S;Motwani M;Chan J;Sharma S;Hennessy EJ;FitzGerald GA;McManus MT;Rinn JL;Fitzgerald KA;Carpenter S
• 通讯作者: Carpenter S

Inheritance of protection from osmotic stress.

渗透应激保护的遗传。

• DOI: 10.1038/ncb3483
• 发表时间: 2017
• 期刊: Nature cell biology
• 影响因子: 21.3
• 作者: Kaneshiro,KiyomiR;Strome,Susan
• 通讯作者: Strome,Susan

All hematopoietic cells develop from hematopoietic stem cells through Flk2/Flt3-positive progenitor cells.

• DOI: 10.1016/j.stem.2011.04.021
• 发表时间: 2011-07-08
• 期刊: CELL STEM CELL
• 影响因子: 23.9
• 作者: Boyer, Scott W.;Schroeder, Aaron V.;Smith-Berdan, Stephanie;Forsberg, E. Camilla
• 通讯作者: Forsberg, E. Camilla

Mammary Stem Cell Self-Renewal Is Regulated by Slit2/Robo1 Signaling through SNAI1 and mINSC.

乳细胞自我更新受SNAI1和MINSC信号传导调节。

• DOI: 10.1016/j.celrep.2015.09.006
• 发表时间: 2015-10-13
• 期刊: Cell reports
• 影响因子: 8.8
• 作者: Ballard MS;Zhu A;Iwai N;Stensrud M;Mapps A;Postiglione MP;Knoblich JA;Hinck L
• 通讯作者: Hinck L