Training Program in Molecular, Cell, and Developmental Biology

分子、细胞和发育生物学培训项目

• 批准号: 9522000
• 负责人: Susan Strome
• 金额: $ 28.48万
• 依托单位: UNIVERSITY OF CALIFORNIA SANTA CRUZ
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9522000
• 关键词: Cellular biology; Developmental Biology; Molecular Biology; Training Programs

DESCRIPTION (provided by applicant): The goals of the UCSC Graduate Training Program in Molecular, Cell and Developmental Biology are to recruit highly motivated graduate students, provide them with critical thinking skills, expertise in experimental design and interpretation, an a strong framework of knowledge, while also amplifying their passion for inquiry and discovery. We strongly encourage interdisciplinary and collaborative research that crosses departmental, divisional, and even institutional boundaries. Intellectual, cultural, and socioeconomic diversity are prevalent in our graduate student population, and we constantly seek new approaches to attract and inspire students from under-represented groups. Our Training Program prepares students to pursue diverse careers in biomedical research, teaching, government, and industry. First-year trainees participate in three 6-week research rotations and in a core curriculum designed to train them in the logic of experimental analysis. Students learn how to evaluate published research, effectively argue scientific points, formulate hypotheses, design rigorous experiments, and write research manuscripts and proposals with intellectual depth. Students join a laboratory to pursue their Ph.D. thesis research in Spring of their first year. Second-year students train in the responsible conduct of research and take an oral qualifying exam. Third-year students present a full research seminar to the Training Program. Students at all stages participate in departmental seminars, research meetings, and journal clubs, and take advanced elective courses of their choosing. These broaden their training experience and promote interactions among trainees and faculty. Training culminates with a written Ph.D. dissertation and oral defense. Our Training Program includes 30 faculty from 5 departments, including the Departments of Molecular, Cell and Developmental Biology, Biomolecular Engineering, Chemistry and Biochemistry, Microbiology and Environmental Toxicology, and Physics. Participating laboratories are intermingled in 3 adjacent buildings on "science hill", which encourages interaction and collaboration. Research in the Training Program utilizes a wide variety of approaches, and is organized with interdisciplinary clusters of common interests (e.g. Cell Biology, Chromatin, Neurobiology, and RNA), thereby creating critical masses of researchers that foster mutual support and scientific creativity. Many training faculty work on systems that are directly relevant to human health, including stem cell biology, malaria, cholera, cancer biology, host-pathogen interactions, neurodegenerative diseases, and the responses of neurons to stroke and other damage. Other faculty carry out basic research that provides the foundation for understanding topics relevant to human health, including cell division, signaling, meiosis, chromatin organization, cell differentiation, and neurobiology. Our Training Grant, currently in its 14th year, supports 6 trainees. In this renewal, we are requesting support for 8 trainees. Training Grant positions will continue to be awarded to our most promising students.

描述（由申请人提供）：UCSC分子，细胞和发育生物学研究生培训计划的目标是招募积极性很高的研究生，为他们提供批判性思维技能，实验设计和解释的专业知识，强大的知识框架，同时也增强了他们对探究和发现的热情。我们强烈鼓励跨学科和合作研究，跨越部门，部门，甚至机构的界限。智力，文化和社会经济多样性在我们的研究生群体中普遍存在，我们不断寻求新的方法来吸引和激励来自代表性不足群体的学生。我们的培训计划为学生在生物医学研究，教学，政府和行业中追求多样化的职业做好准备。一年级学员参加三次为期6周的研究轮换，并参加旨在培训他们实验分析逻辑的核心课程。学生学习如何评估已发表的研究，有效地论证科学观点，制定假设，设计严格的实验，并撰写具有知识深度的研究手稿和提案。学生加入实验室攻读博士学位。在第一年的春季进行论文研究。二年级的学生在负责任的研究行为进行培训，并采取口头资格考试。三年级的学生提出了一个完整的研究研讨会的培训计划。学生在各个阶段参加部门研讨会，研究会议和期刊俱乐部，并采取他们选择的高级选修课程。这些活动扩大了他们的培训经验，促进了学员和教师之间的互动。培训最终以书面博士学位结束。论文和口头答辩。我们的培训计划包括来自5个部门的30名教师，包括分子，细胞和发育生物学，生物分子工程，化学和生物化学，微生物学和环境毒理学以及物理学部门。参与的实验室分布在“科学山”上的三个相邻的建筑中，这鼓励了互动和合作。在培训计划的研究利用各种各样的方法，并与共同利益的跨学科集群（例如细胞生物学，染色质，神经生物学和RNA）组织，从而创造研究人员的临界质量，促进相互支持和科学创造力。许多培训教师从事与人类健康直接相关的系统，包括干细胞生物学，疟疾，霍乱，癌症生物学，宿主-病原体相互作用，神经退行性疾病以及神经元对中风和其他损伤的反应。其他教师开展基础研究，为理解与人类健康相关的主题提供基础，包括细胞分裂，信号传导，减数分裂，染色质组织，细胞分化和神经生物学。我们的培训补助金，目前在其第14年，支持6名学员。在这次更新中，我们要求为8名受训人员提供支持。培训补助金职位将继续授予我们最有前途的学生。

项目成果

Genetic Models Reveal cis and trans Immune-Regulatory Activities for lincRNA-Cox2.

• DOI: 10.1016/j.celrep.2018.10.027
• 发表时间: 2018-11-06
• 期刊: Cell reports
• 影响因子: 8.8
• 作者: Elling R;Robinson EK;Shapleigh B;Liapis SC;Covarrubias S;Katzman S;Groff AF;Jiang Z;Agarwal S;Motwani M;Chan J;Sharma S;Hennessy EJ;FitzGerald GA;McManus MT;Rinn JL;Fitzgerald KA;Carpenter S
• 通讯作者: Carpenter S

Mutating two putative phosphorylation sites on ZHP-3 does not affect its localization or function during meiotic chromosome segregation.

• DOI: 10.17912/micropub.biology.000354
• 发表时间: 2021-01-18
• 期刊: microPublication biology
• 作者: Russo AE;Nelson CR;Bhalla N
• 通讯作者: Bhalla N

Inheritance of protection from osmotic stress.

渗透应激保护的遗传。

• DOI: 10.1038/ncb3483
• 发表时间: 2017
• 期刊: Nature cell biology
• 影响因子: 21.3
• 作者: Kaneshiro,KiyomiR;Strome,Susan
• 通讯作者: Strome,Susan

All hematopoietic cells develop from hematopoietic stem cells through Flk2/Flt3-positive progenitor cells.

• DOI: 10.1016/j.stem.2011.04.021
• 发表时间: 2011-07-08
• 期刊: CELL STEM CELL
• 影响因子: 23.9
• 作者: Boyer, Scott W.;Schroeder, Aaron V.;Smith-Berdan, Stephanie;Forsberg, E. Camilla
• 通讯作者: Forsberg, E. Camilla

Mammary Stem Cell Self-Renewal Is Regulated by Slit2/Robo1 Signaling through SNAI1 and mINSC.

乳细胞自我更新受SNAI1和MINSC信号传导调节。

• DOI: 10.1016/j.celrep.2015.09.006
• 发表时间: 2015-10-13
• 期刊: Cell reports
• 影响因子: 8.8
• 作者: Ballard MS;Zhu A;Iwai N;Stensrud M;Mapps A;Postiglione MP;Knoblich JA;Hinck L
• 通讯作者: Hinck L