A Limited-angle Intra-fractional Verification (LIVE) System for SBRT Treatments
用于 SBRT 治疗的有限角度分次验证 (LIVE) 系统
基本信息
- 批准号:9181385
- 负责人:
- 金额:$ 36.33万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-12-12 至 2018-11-30
- 项目状态:已结题
- 来源:
- 关键词:15p4D ImagingAccelerationAlgorithmsAnatomyBrainBreastCancer PatientCardiacChestComplicationComputer softwareDataDiagnostic radiologic examinationDoseDropsEffectivenessEvaluationFinancial compensationFluoroscopyGoalsGoldImageImaging TechniquesIntensity-Modulated RadiotherapyInterruptionKnowledgeLiverLocationLungLung NeoplasmsMechanicsMethodsModelingModificationMono-SMonte Carlo MethodMotionNon-Small-Cell Lung CarcinomaNormal tissue morphologyPatientsPhasePositioning AttributeProbabilityProstateRadiation therapyReportingResearchRetrospective StudiesRotationScanningSorting - Cell MovementStructureSystemTechniquesTimeToxic effectTumor VolumeVertebral columnX-Ray Computed Tomographybaseclinical research sitecone-beam computed tomographydigitaleffective therapyimage guided radiation therapyimprovedinnovationknowledge basenew technologynovelparallelizationpublic health relevancereconstructionrespiratorysuccesstomosynthesistumorvirtual
项目摘要
DESCRIPTION (provided by applicant):
Stereotactic body radiation therapy (SBRT) has become an effective treatment paradigm for early stage non- small cell lung cancer (NSCLC) patients. The success of lung SBRT is determined by the accuracy of target localization as well as sparing of critical normal structures.
Intrafraction verification is critical for lung SBRT due to its tight PTV margin, high fractional dse with small fraction number, and long treatment time. Purdie et al showed that lung tumor intrafraction motion increases with treatment time, and can be over 1cm for SBRT. Zhao et al reported a maximal drop of PTV coverage from 95% to 78% in lung SBRT using 5mm margin due to intrafraction motion. The accuracy of using kV fluoroscopy and MV cine imaging for intrafraction verification is limited especially for small tumors due to overlaying structures in 2 images. Conventional CBCT also has limited application for intrafraction verification due to large scanning angle, long acquisition time, high imaging dose and limited mechanical clearance. By far, neither 3D nor 4D volumetric x-ray imaging techniques are available for target verification on-the-fly during actual treatment delivery. This research plan proposes to develop a Limited-angle Intrafraction Verification (LIVE) system for fast 4D verification during arc treatment delivery or in between 3D/IMRT beams. The long term goal of the LIVE system is to improve the tumor control and reduce normal tissue toxicity for lung SBRT by substantially reducing the treatment errors caused by intrafraction motion and improving the accuracy of ART. The specific aims of the proposal are: 1) Build the LIVE system by developing novel image acquisition, sorting, kV-MV aggregation and reconstruction techniques. 2) Optimize the accuracy, efficiency and imaging dose of LIVE through respiratory motion modeling, novel acceleration strategies, and XCAT and Monte Carlo (MC) simulation. 3) Evaluate the LIVE system for IGRT and ART. LIVE creatively combined a number of new technologies being developed for fast intrafraction verification: 1) limited-angle kV-MV image acquisition; 2) automatic projection sorting based on Fourier Transformation of projections; 3) kV-MV aggregation using linear fitting, virtual mono-energetic and dual CT techniques; 4) 4D- and phase-matched digital tomosynthesis (DTS) and prior knowledge based CBCT reconstruction methods; 5) respiratory motion modeling; 6) adaptive reconstruction strategy; and 7) new acceleration strategies. Parameters of the LIVE system, including beam energy, fluence, kV-MV imaging sequence, number of kV-MV projections, and scan angle will be optimized for different tumor sizes and locations through 4D digital extended cardiac-torso phantom (XCAT) and Monte Carlo (MC) simulation. MC will also be used to evaluate the imaging dose. The effectiveness of LIVE system for IGRT and ART applications will be quantitatively evaluated through phantom studies using the CIRS dynamic thorax motion phantom and patient studies using lung patient CBCT and MV cine image data collected in a retrospective study.
描述(由申请人提供):
立体定向全身放射治疗(SBRT)已成为早期非小细胞肺癌(NSCLC)的有效治疗方案。肺SBRT的成功与否取决于靶点定位的准确性以及对关键正常结构的保留。
片内验证对于肺SBRT来说是至关重要的,因为它的PTV边缘很紧,DSE分数高,片数少,治疗时间长。Purdie等人发现,肺癌的内部运动随治疗时间的延长而增加,SBRT可达1 cm以上。赵等人报道,在使用5 mm边界的肺SBRT中,由于小腿内运动,PTV覆盖率从95%下降到78%。KV透视和MV电影成像用于片内验证的准确性受到限制,特别是对于小肿瘤,因为2个图像中的结构重叠。传统的CBCT扫描角度大、采集时间长、成像剂量大、机械间隙有限,在片内验证中的应用也受到限制。到目前为止,还没有3D或4D体积X射线成像技术可用于在实际治疗过程中进行即时目标验证。这项研究计划建议开发一个有限角度分数内验证(LIVE)系统,用于在弧光处理交付期间或在3D/IMRT波束之间进行快速4D验证。LIVE系统的长期目标是通过大幅减少分数内运动引起的治疗错误和提高ART的准确性,改善肿瘤控制,减少肺SBRT的正常组织毒性。该方案的具体目标是:1)通过开发新的图像采集、分类、千伏聚合和重建技术来构建实时系统。2)通过呼吸运动建模、新颖的加速策略、xCAT和蒙特卡罗(MC)模拟,优化Liver的准确性、效率和成像剂量。3)对带电系统进行IGRT和ART评估。LIVE创造性地结合了一些正在开发的用于快速分数内验证的新技术:1)有限角度的千伏图像采集;2)基于投影傅立叶变换的自动投影排序;3)使用线性拟合、虚拟单能量和双CT技术的千伏聚合;4)基于四维和相位匹配的数字断层合成(DTS)和基于先验知识的CBCT重建方法;5)呼吸运动建模;6)自适应重建策略;以及7)新的加速策略。通过4D数字扩展心脏-躯干体模(XCAT)和蒙特卡罗(MC)模拟,LIVE系统的参数,包括束流能量、通量、千伏-毫伏成像序列、千伏-毫伏投影数和扫描角度,将针对不同的肿瘤大小和位置进行优化。MC也将被用来评估成像剂量。对于IGRT和ART的应用,LIVE系统的有效性将通过使用CIRS动态胸腔运动体模的体模研究和使用在回顾性研究中收集的肺患者CBCT和MV电影图像数据的患者研究来定量评估。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Lei Ren其他文献
Lei Ren的其他文献
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{{ truncateString('Lei Ren', 18)}}的其他基金
Hybrid virtual-MRI/CBCT: A new paradigm for image guidance in liver SBRT
混合虚拟 MRI/CBCT:肝脏 SBRT 图像引导的新范例
- 批准号:
10021659 - 财政年份:2019
- 资助金额:
$ 36.33万 - 项目类别:
Hybrid virtual-MRI/CBCT: A new paradigm for image guidance in liver SBRT
混合虚拟 MRI/CBCT:肝脏 SBRT 图像引导的新范例
- 批准号:
10463464 - 财政年份:2019
- 资助金额:
$ 36.33万 - 项目类别:
Hybrid virtual-MRI/CBCT: A new paradigm for image guidance in liver SBRT
混合虚拟 MRI/CBCT:肝脏 SBRT 图像引导的新范例
- 批准号:
10229488 - 财政年份:2019
- 资助金额:
$ 36.33万 - 项目类别:
A Limited-angle Intra-fractional Verification (LIVE) System for SBRT Treatments
用于 SBRT 治疗的有限角度分次验证 (LIVE) 系统
- 批准号:
8986164 - 财政年份:2014
- 资助金额:
$ 36.33万 - 项目类别:
A Limited-angle Intra-fractional Verification (LIVE) System for SBRT Treatments
用于 SBRT 治疗的有限角度分次验证 (LIVE) 系统
- 批准号:
8818761 - 财政年份:2014
- 资助金额:
$ 36.33万 - 项目类别:
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