AIR POLLUTION, RACE, SES & ASTHMA HOSPITALIZATION RISK

空气污染、种族、社会经济地位

• 批准号: 6382384
• 负责人: Stephen K. Van Den Eeden
• 金额: $ 30.73万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-15 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6382384
• 关键词: age difference; air pollution; asthma; clinical research; disease /disorder proneness /risk; environmental contamination; environmental exposure; environmental health; gender difference; hospital utilization; human subject; racial /ethnic difference; respiratory disorder epidemiology; socioeconomics

DESCRIPTION (Adapted from applicant's abstract): We propose to conduct estimate how this association is modified by race/ethnicity, socioeconomic position, severity, age, and gender. Our hypothesis is that subgroups and/or disadvantaged populations will be more vulnerable to the effects of ambient air pollution. The study setting is Kaiser Permanente (KP) in Northern and Southern California, a large managed care organization with a base population of over 5.2 million people. Cases will be defined as members of KP who were hospitalized with a diagnosis of asthma (ICD-9 493) between 1997 and 2000 (n=11,800). Race/ethnicity, age and gender will be obtained from Kaiser Permanente databases, while socioeconomic data will be obtained by geocoding and linking to US census information. Severity will be derived from utilization databases in KP. Ambient air pollution and meteorologic data will be ascertained from ambient monitoring stations. Exposure and meteorologic factors will be mapped to the geographic areas and exposure assigned to each individual based on his or her residential address. Exposure related to the event for each individual will be compared to exposures on reference days using conditional logistic regression to estimate the risk of an asthma hospitalization associated with exposure to ambient air pollution. After adjusted for potential confounders, such as meteorology, and interactions with race/ethnicity, age, gender, disease severity, and socioeconomic position will be examined. This will be the first such epidemiologic study to look at most of these factors on a population-wide basis. This study will address a previously understudied question and if the results demonstrate that minorities and/or people living in lower SES areas are at higher risk for acute health effects from ambient air pollution, there will be research and policy implications.

描述（改编自申请人的摘要）：我们建议进行 估计这种关联如何因种族/民族、社会经济而改变 位置、严重程度、年龄和性别。我们的假设是子组和/或 弱势群体将更容易受到环境空气的影响 污染。 研究地点是北部和南部的 Kaiser Permanente (KP) 加利福尼亚州，一家大型管理式医疗组织，基数超过 520万人。案例将被定义为以下 KP 成员： 1997 年至 2000 年间因诊断为哮喘 (ICD-9 493) 住院 （n=11,800）。种族/民族、年龄和性别将从 Kaiser 获取 永久数据库，而社会经济数据将通过地理编码获得 并链接到美国人口普查信息。严重性取决于利用率 KP 中的数据库。环境空气污染和气象数据将 由环境监测站确定。暴露和气象因素 将被映射到地理区域并分配给每个人的暴露 基于他或她的居住地址。 每个人与事件相关的暴露将与暴露进行比较 在参考日使用条件逻辑回归来估计风险 因暴露于环境空气污染而导致的哮喘住院。 针对潜在的混杂因素（例如气象和相互作用）进行调整后 与种族/民族、年龄、性别、疾病严重程度和社会经济地位 将接受检查。这将是第一个此类流行病学研究 其中大部分因素是针对整个人口的。 这项研究将解决一个先前未充分研究的问题，以及结果是否 证明少数群体和/或生活在社会经济地位较低地区的人们 环境空气污染造成急性健康影响的风险更高， 研究和政策影响。