AUTISM RISK AND EXPOSURES/BIOMARKERS DURING PRE-, PERI, AND NEONATAL PERIODS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 自闭症风险和暴露/生物标记物在先期、围产期和新生儿期的测量：一项婴儿兄弟姐妹的初步调查 PI：Craig J.Newschaffer，博士 有强有力的证据支持自闭症的早期起源。出于这个原因，怀孕期间收集的数据可能为自闭症的原因提供重要线索。该项目是一项试验性研究，将收集自闭症儿童母亲在随后怀孕期间的信息和生物样本。通过这样做，我们希望了解如何最好地收集和分析这种类型的数据，以便我们能够在未来成功地实施更大规模的研究。这项大型研究将解决以下问题：在怀孕期间或生命早期测量的暴露或生物标志物是否会增加患有自闭症儿童的兄弟姐妹本身患上自闭症谱系障碍的风险。对这一设计的研究可以帮助我们理清基因易感性和早期环境暴露之间的复杂相互关系，这些因素可能共同作用导致自闭症。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Autism risk and exposures/biomarkers measured during the pre-, peri-, and neonatal periods: a baby sibs pilot investigation PI: Craig J. Newschaffer, Ph.D. There is strong evidence supporting the early origins of autism. For this reason, data collected during pregnancy could provide an important clue into the cause of autism. This project is a pilot study that will collect information and biologic samples from mothers of autistic children during the course of a subsequent pregnancy. By doing this we hope to learn how best to collect and analyze this type of data so that we can successfully implement a larger study in the future. This large study would address the question of whether exposures or biomarkers measured during pregnancy or very early in life increase the risk of a sibling of a child with autism themselves developing an autism spectrum disorder. A study of this design could help us untangle the complex inter-relationships between genetic predisposition and early environmental exposures that likely work together to cause autism.