Washington University MAPP Network Discovery Site

描述(由申请者提供)：这是一份来自华盛顿大学发现网站的申请，要求继续参与Mapp研究网络。MAPP于2008年10月推出，旨在更好地了解泌尿系统慢性盆腔疼痛综合征(UCPPS)，包括男性和女性的间质性膀胱炎/膀胱疼痛综合征(IC/BPS)，以及男性的慢性前列腺炎/慢性盆腔疼痛综合征(CP/CPPS)。通过MAPP第一阶段的一系列科学发现项目，我们使用概括UCPPS关键临床症状的临床前模型，更好地了解了UCPPS疼痛的表型亚型、生物标记物、症状恶化(FLARE)的流行病学因素、UCPPS疼痛的生理相关性(例如，定量感觉测试、解剖和功能神经成像)以及盆腔疼痛的机制基础。华盛顿大学发现号网站的工作效率尤其高。到目前为止，我们已经发表了九份出版物，涵盖了UCPPS表型、症状、感染性和膀胱痛的动物研究等关键领域。我们已经达到并超过了我们的招聘目标25%。事实上，我们招募了比其他任何网站更多的UCPP和健康控制人员。我们在为生物标记物研究收集生物标本方面也有97%的成功率。对于MAPP-II，我们提出了以下五个具体目标：目标1：通过MAPP研究网络进行症状模式研究。初步数据显示，UCPPS参与者的某些亚组在六个月的过程中往往会改善他们的症状，而其他亚组的症状往往会恶化。在这里，我们提出了一项前瞻性观察研究，以确定与较长时间的三年尿路和非尿路症状恶化和/或改善相关的表型因素。这项拟议的研究之所以重要，原因有很多。在最基本的水平上，能够准确地预测个别患者的UCPPS症状的临床过程将是有帮助的。这些信息对指导管理决策至关重要。更好地了解UCPPS的内源性表型对于开发更有效和个性化的治疗方法至关重要。此外，我们将提出以下扩展评估以加强核心症状模式研究：目标2：定量感觉测试、盆底和躯体负荷的扩展评估。目的3：UCPPS症状加重(UCPPS症状加重)的扩展评估目标4：UCPPS的尿代谢谱目标5：使用临床前模型进行双向翻译研究

DESCRIPTION (provided by applicant): This is an application from the Washington University Discovery Site to continue participation in the MAPP Research Network. The MAPP was launched in October 2008 to better understand urologic chronic pelvic pain syndromes (UCPPS), which include interstitial cystitis/ bladder pain syndrome (IC/BPS) in men and women, and chronic prostatitis/ chronic pelvic pain syndrome (CP/CPPS) in men. Through a wide range of scientific discovery projects in Phase 1 of the MAPP, we have better understanding of the phenotype subgroups, biomarkers, epidemiological factors of symptom exacerbation ("flare"), physiological correlates of UCPPS pain (e.g. quantitative sensory testing, anatomic and functional neuroimaging), and mechanistic underpinnings of pelvic pain, using preclinical models that recapitulated the key clinical symptoms of UCPPS. The Washington University Discovery Site has been particularly productive. We have nine publications so far, covering key areas such as UCPPS phenotypes, flares, infectious, and animal studies of bladder pain. We have met and exceeded our recruitment target by 25%. In fact, we have recruited more UCPPS and healthy controls than any other sites. We also have a 97% success rate in collecting biospecimens for the biomarker studies. For MAPP-II, we propose the following five specific aims: Aim 1: To conduct a Symptom Patterns Study across the MAPP Research Network. Preliminary data suggested that certain subgroups of UCPPS participants tend to improve their symptoms over the course of six months, whereas other subgroups tend to worsen. Here we propose a prospective observational study to identify phenotypic factors associated with worsening and/or improvement of urinary and non-urinary symptoms over a longer period of three years. The proposed study is important for many reasons. At the most basic level, it would be helpful to be able to accurately predict the clinical course of UCPPS symptoms for individual patients. This information is vital to guide management decisions. Having a better understanding of the UCPPS endo-phenotypes would be crucial to developing more effective and personalized treatments. In addition, we will propose the following expanded assessment to enhance the core Symptom Patterns Study: Aim 2: Expanded Assessment of Quantitative Sensory Testing, Pelvic Floor, and Somatic Burden. Aim 3: An expanded assessment of UCPPS symptom flares (exacerbation of UCPPS symptoms) Aim 4: Urinary Metabolomic Profiles of UCPPS Aim 5: Bi-directional Translational Study Using Preclinical Models