BIOLOGY AND PATHOPHYSIOLOGY OF UROTHELIUM IN BLADDER DISEASE

描述（由申请人提供）：申请建立良性泌尿外科跨学科研究中心，研究方向为“膀胱疾病中尿路上皮的生物学和病理生理学”。总体的、长期的目标是开发和整合基础和临床研究的资源，这将促进我们对膀胱损伤和修复生物学的理解从临床前到临床的快速转化。该计划中心的近期目标是汇集一个跨学科的研究团队，他们拥有不同领域的专业知识，以制定和建立一个多管齐下的系统方法来研究膀胱损伤及其在小鼠模型和人类患者中的影响。多学科团队包括执业泌尿科医生、基础科学家和对膀胱感染、损伤和修复过程感兴趣的病理学家；膀胱疼痛、排尿和神经病学；尿路上皮干细胞的稳态、激活及其与细胞外基质的相互作用临床资料和标本的高通量收集和储存。该科学研究项目有三个目标，将定义伴随小鼠各种膀胱损伤模型的细胞、分子和神经生物学变化，然后将这些变化与良性人类膀胱疾病发生的变化联系起来。这一过程还将导致建立急需的基础设施，以开展多方面的膀胱疾病研究（从实验室到床边）。该中心包括一个行政核心，负责促进合作和监督教育充实计划。该计划将安排外部演讲者访问华盛顿大学，介绍与中心目标相关的研讨会。此外，该计划将支持暑期学生在泌尿科相关实验室的研究经验，为高中，大学和医学院的学生。总之，该中心支持的研究和教育活动将使该团队在了解良性下尿路尿路上皮疾病和相关疼痛的生物学方面取得实质性进展。

DESCRIPTION (provided by applicant): This is a proposal to establish an Interdisciplinary Research Center in Benign Urology focused on "Biology and Pathophysiology of Urothelium in Bladder Disease." The overarching, long term goals are to develop and integrate resources in basic and clinical investigation that will catalyze the rapid translation of breakthroughs in our understanding of the biology of bladder injury and repair from the preclinical to the clinical setting. The immediate goal of this Planning Center is to bring together an interdisciplinary team of researchers with diverse areas of expertise to formulate and establish a multi-pronged, systematic approach for investigating bladder injury and its effects in both mouse models and in human patients. The multidisciplinary Team includes practicing urologists, basic scientists, and pathologists with interests in bladder infection, injury, and repair processes; bladder pain, micturition and neurourology; urothelial stem cell homeostasis, activation, and interactions with extracellular matrix; and high throughput collection and banking of clinical information and specimens. The scientific research project has three Aims that will define cellular, molecular, and neurobiological changes that accompany various bladder injury models in mice and then correlate these with changes that occur in benign human bladder diseases. This process will also lead to establishment of much needed infrastructure to conduct multifaceted research in bladder diseases (bench to bedside). The Center includes an Administrative Core responsible for fostering collaborations and overseeing an Educational Enrichment Program. This Program will arrange visits to Washington University by outside speakers to present seminars relevant to the goals of the Center. In addition, the Program will support Summer Student Research Experiences in Urology-relevant labs for high school, college, and medical students. Together, the research and educational activities supported by the Center will allow the Team to make substantial inroads into understanding the biology of benign lower urinary tract urothelial diseases and the associated pain.