Clinical Evaluation and Treatment Center for BPH

描述（由申请人提供）：由良性前列腺增生（BPH）引起的下尿路症状（LUTS）是老年男性最常见的疾病之一。在过去的十年中，这种异常的特征和药物治疗（如α受体阻滞剂和α还原酶抑制剂）和微创手术技术（如支架、激光、热疗等）的治疗取得了重大进展。尽管如此，近年来使用非传统医学治疗LUTS的人数大大增加。大多数评估这些药物的试验受到规模小、研究间隔短和缺乏标准化测试工具的限制。由于这些原因，有必要在大规模、随机、安慰剂对照的长期试验中评估非传统药物，如锯棕榈和非洲皮草。在本申请中，我们建议继续进行这样的研究。

DESCRIPTION (provided by applicant): Lower Urinary Tract Symptoms(LUTS) due to benign prostatic hyperplasia (BPH) are one ofthe most common disorders ofthe aging male. Over the last decade significant advances have been made in characterizing this abnormality and treating it with medical therapy (such as alpha blockers and Salpha reductase inhibitors) and minimmally invasive surgical techniques (such as stents, lasers, hyperthermia and others). Despite thism use of non-traditional medical therapied for LUTS has greatly increased in recent years. Most trials evaluating these agents are limited by small size, short study interval and absence of standardized testing instruments. For these reasons there is a need to evaluate non-traditional agents such as saw palmetto and pygeum Africanum in a large scale, randomized, placebo-controlled Long term trial. In this application, we propose the continuation of onesuch study. PUBLIC HEALTH RELEVANCE: LUTS is very common in the older male population. Finding a non-traditional treatment to these patients is a common request and would add greatly to their quality of life.