BIOLOGY AND PATHOPHYSIOLOGY OF UROTHELIUM IN BLADDER DISEASE

描述(申请人提供)：这是一个关于建立一个良性泌尿外科跨学科研究中心的建议，重点是“膀胱疾病中的尿路上皮的生物学和病理生理学”。总体的、长期的目标是开发和整合基础和临床研究中的资源，这些资源将促进我们对膀胱损伤和修复生物学的突破从临床前到临床环境的快速转化。该计划中心的近期目标是汇聚一个具有不同专业领域的跨学科研究团队，以制定和建立一种多管齐下的系统方法，以研究膀胱损伤及其在小鼠模型和人类患者中的影响。这个多学科团队包括执业泌尿科医生、基础科学家和病理学家，他们对以下领域感兴趣：膀胱感染、损伤和修复过程；膀胱疼痛、排尿和神经病学；尿路上皮干细胞的动态平衡、激活及其与细胞外基质的相互作用；以及临床信息和标本的高通量收集和存储。该科学研究项目有三个目标，将定义伴随着各种小鼠膀胱损伤模型的细胞、分子和神经生物学变化，然后将这些变化与人类良性膀胱疾病中发生的变化联系起来。这一进程还将导致建立急需的基础设施，以进行多方面的膀胱疾病研究(从工作台到床边)。该中心包括一个负责促进合作和监督教育丰富计划的行政核心。该计划将安排外部演讲者访问华盛顿大学，介绍与中心目标相关的研讨会。此外，该计划将支持高中生、大学生和医学生在与泌尿外科相关的实验室中的暑期学生研究体验。总而言之，该中心支持的研究和教育活动将使该团队能够在了解良性下尿路尿路上皮疾病及其相关疼痛的生物学方面取得实质性进展。

DESCRIPTION (provided by applicant): This is a proposal to establish an Interdisciplinary Research Center in Benign Urology focused on "Biology and Pathophysiology of Urothelium in Bladder Disease." The overarching, long term goals are to develop and integrate resources in basic and clinical investigation that will catalyze the rapid translation of breakthroughs in our understanding of the biology of bladder injury and repair from the preclinical to the clinical setting. The immediate goal of this Planning Center is to bring together an interdisciplinary team of researchers with diverse areas of expertise to formulate and establish a multi-pronged, systematic approach for investigating bladder injury and its effects in both mouse models and in human patients. The multidisciplinary Team includes practicing urologists, basic scientists, and pathologists with interests in bladder infection, injury, and repair processes; bladder pain, micturition and neurourology; urothelial stem cell homeostasis, activation, and interactions with extracellular matrix; and high throughput collection and banking of clinical information and specimens. The scientific research project has three Aims that will define cellular, molecular, and neurobiological changes that accompany various bladder injury models in mice and then correlate these with changes that occur in benign human bladder diseases. This process will also lead to establishment of much needed infrastructure to conduct multifaceted research in bladder diseases (bench to bedside). The Center includes an Administrative Core responsible for fostering collaborations and overseeing an Educational Enrichment Program. This Program will arrange visits to Washington University by outside speakers to present seminars relevant to the goals of the Center. In addition, the Program will support Summer Student Research Experiences in Urology-relevant labs for high school, college, and medical students. Together, the research and educational activities supported by the Center will allow the Team to make substantial inroads into understanding the biology of benign lower urinary tract urothelial diseases and the associated pain.