BIOLOGY AND PATHOPHYSIOLOGY OF UROTHELIUM IN BLADDER DISEASE

这是一项建立良性泌尿外科跨学科研究中心的建议，该研究中心的重点是“生物学” 和膀胱疾病的尿路系统的病理生理学。 并整合基础和临床研究中的资源，以催化快速翻译 从临床前到临床前，我们对膀胱损伤和修复生物学的理解取得了突破 临床环境。该计划中心的近期目标是汇聚一个跨学科的团队， 具有不同专业领域的研究人员，以制定和建立多管齐下的系统化方法 用于研究膀胱损伤及其在小鼠模型和人类患者中的影响。这个 多学科团队包括对以下领域感兴趣的执业泌尿科医生、基础科学家和病理学家 膀胱感染、损伤和修复过程；膀胱疼痛、排尿和神经内科；尿路上皮干 细胞动态平衡、激活和与细胞外基质的相互作用；以及高通量收集和 临床信息和标本资料库。科学研究项目有三个目标，这将定义 小鼠不同膀胱损伤模型的细胞、分子和神经生物学变化 然后将这些与人类良性膀胱疾病中发生的变化联系起来。这一进程还将导致 建立急需的基础设施，以进行多方面的膀胱疾病研究(BASE 到床边)。该中心包括一个管理核心，负责促进协作和 监督教育充实计划。该项目将安排访问华盛顿大学 由外部发言者介绍与中心目标有关的研讨会。此外，该计划将 支持暑期学生在高中、大学和大学的泌尿相关实验室的研究经验 医科学生。该中心支持的研究和教育活动将使 团队将在了解良性下尿路尿路上皮生物学方面取得实质性进展 疾病和相关的痛苦。

This is a proposal to establish an Interdisciplinary Research Center in Benign Urology focused on "Biology and Pathophysiology of Urotheliunn in Bladder Disease." The overarching, long term goals are to develop and integrate resources in basic and clinical investigation that will catalyze the rapid translation of breakthroughs in our understanding of the biology of bladder injury and repair from the preclinical to the clinical setting. The immediate goal of this Planning Center is to bring together an interdisciplinary team of researchers with diverse areas of expertise to formulate and establish a multi-pronged, systematic approach for investigating bladder injury and its effects in both mouse models and in human patients. The multidisciplinary Team includes practicing urologists, basic scientists, and pathologists with interests in bladder infection, injury, and repair processes; bladder pain, micturition and neurourology; urothelial stem cell homeostasis, activation, and interactions with extracellular matrix; and high throughput collection and banking of clinical information and specimens. The scientific research project has three Aims that will define cellular, molecular, and neurobiological changes that accompany various bladder injury models in mice and then correlate these with changes that occur in benign human bladder diseases. This process will also lead to establishment of much needed infrastructure to conduct multifaceted research in bladder diseases (bench to bedside). The Center includes an Administrative Core responsible for fostering collaborations and overseeing an Educational Enrichment Program. This Program will arrange visits to Washington University by outside speakers to present seminars relevant to the goals of the Center. In addition, the Program will support Summer Student Research Experiences in Urology-relevant labs for high school, college, and medical students. Together, the research and educational activities supported by the Center will allow the Team to make substantial inroads into understanding the biology of benign lower urinary tract urothelial diseases and the associated pain.