Ultra Focus Digital Radiography System with DXA

带 DXA 的超聚焦数字放射成像系统

• 批准号: 9274762
• 负责人: Matthew A Halanski
• 金额: $ 22.57万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-01 至 2018-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9274762
• 关键词: Anatomy; Anesthesia procedures; Animals; Autopsy; Bone Density; Clinical; Collaborations; Contrast Media; Diagnostic; Digital Radiography; Discipline; Disease Progression; Dual-Energy X-Ray Absorptiometry; Experimental Models; Fatty acid glycerol esters; Fracture; Fracture Healing; Funding; Gold; Health Status; Histologic; Image; Imagery; Maps; Measurement; Metastatic Neoplasm to the Bone; Minor; Monitor; Mus; Organ; Orthopedics; Phenotype; Physiological; Plants; Publications; Research; Research Personnel; Resolution; Resources; Rodent; Roentgen Rays; Scanning; Seeds; Specimen; Structure; System; Technology; Thinness; Three-Dimensional Imaging; Time; Tissues; Wisconsin; animal imaging; bone healing; bone loss; bone mass; comparative; cost; cost effective; design; focus ultra; high resolution imaging; in vivo imaging; preclinical study; soft tissue; therapeutic effectiveness; tool; tumor; user-friendly

PROJECT SUMMARY/ABSTRACT The X-ray unit is a fundamental tool in the clinical setting providing high diagnostic yield for low cost. Its use is over-looked in preclinical studies due to the resolution necessary to visualize anatomical structures relevant to DXA the smaller research species. We requests funds for the purchase of a Faxitron® Ultrafocus to serve as an initial low cost surveillance tool for monitoring the general health status/phenotyping of our rodent species prior to considering more costly and time intensive 3-D imaging. The Faxitron® UltrafocusDXA is a self-contained, cabinet style X-ray system capable of resolving both anatomical/physiological features down to 8 microns. The unit is designed to provide small animal in vivo imaging with inclusion of an anesthesia port and viewing window for monitoring depth of anesthesia. The fine detailed images provide qualitative and quantitative information over a diverse range of experimental models including visualization of tumors with bony metastases, quantifying elongation of bone and healing of bone fractures, and visualization of soft tissue structures (vasculature, organs) via the aide of contrast media. Monitoring of disease progression or therapeutic effectiveness is readily achievable at the whole animal level. The Faxitron is also outfitted with a Dual-energy X-ray Absorptiometry (DXA) component allowing quantitative measurements of bone mass, bone mineral density, % fat and % lean tissue maps. The DXA scanning component provides quantitative measurements of bone loss or gain, and this feature along with the high resolution images allows phenotyping of genetically altered mice. Resulting images are suitable for publication and are of a greater quality than that produced by the Piximus unit (current gold standard). As a testament to its versatility, minor users include the UW Department of Agronomy for seed analysis, Wisconsin Veterinary Diagnostic Lab for necropsy needs (imaging of zoo and wildlife species) and the UW Comparative Orthopaedic Research Lab for histological purposes. Overall, this unit will serve as an excellent cost-effective, user-friendly resource enabling investigators in multiple departments and disciplines to acquire initial surveillance images of animal and plant specimens, and to examine the complexity of various structures in a convenient, accessible format. Such technology will accelerate, enhance, and expand their current research and level of inquiry. It will provide new opportunities for collaboration and external research funding.

项目总结/摘要 X射线设备是临床环境中的基本工具，以低成本提供高诊断率。文化的作用在于 在临床前研究中被忽略，因为可视化解剖结构所需的分辨率 DXA 较小的研究物种。我们申请资金购买Faxitron® Ultrafocus， 初步的低成本监测工具，用于监测我们的啮齿动物物种的一般健康状况/表型， 考虑更昂贵和耗时的3D成像。 Faxitron® UltrafocusDXA是一种独立的箱式X射线系统，能够分辨 解剖学/生理学特征低至8微米。该装置设计用于提供小动物体内 包括麻醉端口和用于监测麻醉深度的观察窗的成像。细 详细的图像提供了各种实验模型的定性和定量信息 包括具有骨转移的肿瘤的可视化、量化骨伸长和骨愈合 骨折，以及借助造影剂使软组织结构（脉管系统、器官）可视化。 疾病进展或治疗效果的监测在整个动物水平上是容易实现的。 Faxitron还配备了双能X射线吸收测定（DXA）组件， 测量骨质量、骨矿物质密度、%脂肪和%瘦组织图。DXA扫描 组件提供骨丢失或获得的定量测量，并且该特征沿着高的骨丢失或获得。 分辨率图像允许对遗传改变的小鼠进行表型分析。生成的图像适用于 出版物和质量更高的比Piximus单位（目前的黄金标准）。 作为其多功能性的证明，次要用户包括用于种子分析的华盛顿大学农学系， 威斯康星州兽医诊断实验室，满足尸检需求（动物园和野生动物物种成像）和华盛顿大学 比较矫形研究实验室用于组织学目的。 总的来说，该股将作为一个具有成本效益和方便用户的极好资源，使调查人员能够 多个部门和专业获取动植物标本的初始监控图像， 以一种方便、可访问的格式检查各种结构的复杂性。这种技术将 加速，加强和扩大他们目前的研究和调查水平。它将为以下方面提供新的机会： 合作和外部研究资金。