Ultra Focus Digital Radiography System with DXA

带 DXA 的超聚焦数字放射成像系统

• 批准号: 9274762
• 负责人: Matthew A Halanski
• 金额: $ 22.57万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-01 至 2018-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9274762
• 关键词: Anatomy; Anesthesia procedures; Animals; Autopsy; Bone Density; Clinical; Collaborations; Contrast Media; Diagnostic; Digital Radiography; Discipline; Disease Progression; Dual-Energy X-Ray Absorptiometry; Experimental Models; Fatty acid glycerol esters; Fracture; Fracture Healing; Funding; Gold; Health Status; Histologic; Image; Imagery; Maps; Measurement; Metastatic Neoplasm to the Bone; Minor; Monitor; Mus; Organ; Orthopedics; Phenotype; Physiological; Plants; Publications; Research; Research Personnel; Resolution; Resources; Rodent; Roentgen Rays; Scanning; Seeds; Specimen; Structure; System; Technology; Thinness; Three-Dimensional Imaging; Time; Tissues; Wisconsin; animal imaging; bone healing; bone loss; bone mass; comparative; cost; cost effective; design; focus ultra; high resolution imaging; in vivo imaging; preclinical study; soft tissue; therapeutic effectiveness; tool; tumor; user-friendly

PROJECT SUMMARY/ABSTRACT The X-ray unit is a fundamental tool in the clinical setting providing high diagnostic yield for low cost. Its use is over-looked in preclinical studies due to the resolution necessary to visualize anatomical structures relevant to DXA the smaller research species. We requests funds for the purchase of a Faxitron® Ultrafocus to serve as an initial low cost surveillance tool for monitoring the general health status/phenotyping of our rodent species prior to considering more costly and time intensive 3-D imaging. The Faxitron® UltrafocusDXA is a self-contained, cabinet style X-ray system capable of resolving both anatomical/physiological features down to 8 microns. The unit is designed to provide small animal in vivo imaging with inclusion of an anesthesia port and viewing window for monitoring depth of anesthesia. The fine detailed images provide qualitative and quantitative information over a diverse range of experimental models including visualization of tumors with bony metastases, quantifying elongation of bone and healing of bone fractures, and visualization of soft tissue structures (vasculature, organs) via the aide of contrast media. Monitoring of disease progression or therapeutic effectiveness is readily achievable at the whole animal level. The Faxitron is also outfitted with a Dual-energy X-ray Absorptiometry (DXA) component allowing quantitative measurements of bone mass, bone mineral density, % fat and % lean tissue maps. The DXA scanning component provides quantitative measurements of bone loss or gain, and this feature along with the high resolution images allows phenotyping of genetically altered mice. Resulting images are suitable for publication and are of a greater quality than that produced by the Piximus unit (current gold standard). As a testament to its versatility, minor users include the UW Department of Agronomy for seed analysis, Wisconsin Veterinary Diagnostic Lab for necropsy needs (imaging of zoo and wildlife species) and the UW Comparative Orthopaedic Research Lab for histological purposes. Overall, this unit will serve as an excellent cost-effective, user-friendly resource enabling investigators in multiple departments and disciplines to acquire initial surveillance images of animal and plant specimens, and to examine the complexity of various structures in a convenient, accessible format. Such technology will accelerate, enhance, and expand their current research and level of inquiry. It will provide new opportunities for collaboration and external research funding.

项目摘要/摘要 X射线单元是临床环境中的基本工具，可为低成本提供高诊断产量。它的使用是 由于可视化与解剖结构所需的分辨率，在临床前研究中的看法过高 DXA 较小的研究物种。我们要求购买FaxItron®Ultrafocus的资金作为 先前，先前监测啮齿动物物种的一般健康状况/表型的初始低成本监视工具 考虑更加昂贵和时间密集的3-D成像。 FaxItron®ultrafocusdxa是一种独立的机柜样式X射线系统，能够解决两者 解剖/生理特征降至8微米。该单元旨在在体内提供小动物 成像，包括麻醉端口和观察窗口，以监测麻醉深度。很好 详细的图像在潜水员的实验模型范围内提供定性和定量信息 包括具有奖励转移肿瘤的可视化，量化骨骼的伸长和骨骼的愈合 裂缝和通过造影剂的助手的软组织结构（脉管系统，器官）的可视化。 在整个动物水平上，可以很容易地对疾病进展或治疗有效性进行监测。 Faxitron还配备了双能X射线吸收仪（DXA）组件，允许定量 测量骨骼质量，骨矿物质密度，％脂肪和％瘦肉组织图。 DXA扫描 组件提供骨质流失或增益的定量测量，此功能以及高 分辨率图像允许对一般改变的小鼠进行表型。结果图像适合 出版物，其质量比Piximus单元（当前黄金标准）更高。 为了证明其多功能性，未成年人包括大学种子分析的大学农学系， 威斯康星州的兽医诊断实验室，用于尸检需求（动物园和野生动物的成像）和UW 用于组织学目的的比较骨科研究实验室。 总体而言，该单元将成为一个出色的成本效益，用户友好的资源，使调查人员可以 多个部门和学科，以获取动物和植物标本的初始监视图像，以及 以方便，可访问的格式检查各种结构的复杂性。这样的技术会 加速，增强和扩大他们当前的研究和询问水平。它将为新的机会 协作和外部研究资金。