Knifeless Limb Lengthening: Critical Advancement of an Innovative Therapy

无刀肢体延长：创新疗法的关键进展

• 批准号: 10355106
• 负责人: Matthew A Halanski
• 金额: $ 21.49万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-15 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10355106
• 关键词: Ablation; Acceleration; Address; Advanced Development; Anatomy; Biomedical Engineering; Bone Growth; Bone Surface; Child; Child Care; Childhood; Clinical; Complication; Data; Deformity; Detection; Dose; Drug Targeting; Ensure; Evaluation; Excision; Fiber; Focused Ultrasound; Fracture; Goals; Growth; Growth Disorders; Individual; Injury; Innovative Therapy; Limb structure; Malignant neoplasm of liver; Measurement; Measures; Mediating; Methods; Microscopic; Modality; Molecular Analysis; Molecular Biology; Morbidity - disease rate; Musculoskeletal; Nerve; Nerve Crush; Nerve Fibers; Operative Surgical Procedures; Orthopedic Surgery; Orthopedics; Patients; Periosteum; Physiologic pulse; Plant Roots; Precision therapeutics; Procedures; Proteolysis; Quality of life; Rehabilitation therapy; Soft Tissue Injuries; Somatotropin; System; Technology; Therapeutic; Tissues; Transducers; Ultrasonic Therapy; Ultrasonics; Ultrasonography; Work; bone; healing; imaging capabilities; improved; injured; long bone; minimally invasive; new technology; response; skeletal; soft tissue; stem cell therapy; success; targeted imaging; ultrasound

PROJECT SUMMARY/ABSTRACT Over 40,000 children in the US are hospitalized for musculoskeletal deformities each year. Abnormal and often diminished skeletal growth is the root cause of many of these conditions. For years, periosteal resection has been shown to accelerate longitudinal bone growth. Previous attempts to surgically exploit this phenomenon as a growth accelerating therapeutic modality have produced variable results that have not justified the procedures’ surgical morbidity and has been a major barrier to widespread clinical use. Recently, we have developed technology capable of performing these procedures non-invasively. However, the current technology lacks the necessary targeting and imaging capabilities to measure and ensure proper energy delivery at the bone surface. Furthermore, the exact portion of the periosteum that must be injured to accelerate growth is unclear. Thus, in the first aim we will determine the component of the periosteum injured during open surgical periosteal resection responsible for physeal growth acceleration and in the second aim we will integrate targeting capabilities into our system to allow precise placement of energy on the periosteum to minimize adjacent soft tissue injury. At the completion of the proposed work, we will have furthered our goal of developing a simple, non-invasive method to modulate skeletal growth.

项目总结/文摘