Knifeless Limb Lengthening: Critical Advancement of an Innovative Therapy

无刀肢体延长：创新疗法的关键进展

• 批准号: 10355106
• 负责人: Matthew A Halanski
• 金额: $ 21.49万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-15 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10355106
• 关键词: Ablation; Acceleration; Address; Advanced Development; Anatomy; Biomedical Engineering; Bone Growth; Bone Surface; Child; Child Care; Childhood; Clinical; Complication; Data; Deformity; Detection; Dose; Drug Targeting; Ensure; Evaluation; Excision; Fiber; Focused Ultrasound; Fracture; Goals; Growth; Growth Disorders; Individual; Injury; Innovative Therapy; Limb structure; Malignant neoplasm of liver; Measurement; Measures; Mediating; Methods; Microscopic; Modality; Molecular Analysis; Molecular Biology; Morbidity - disease rate; Musculoskeletal; Nerve; Nerve Crush; Nerve Fibers; Operative Surgical Procedures; Orthopedic Surgery; Orthopedics; Patients; Periosteum; Physiologic pulse; Plant Roots; Precision therapeutics; Procedures; Proteolysis; Quality of life; Rehabilitation therapy; Soft Tissue Injuries; Somatotropin; System; Technology; Therapeutic; Tissues; Transducers; Ultrasonic Therapy; Ultrasonics; Ultrasonography; Work; bone; healing; imaging capabilities; improved; injured; long bone; minimally invasive; new technology; response; skeletal; soft tissue; stem cell therapy; success; targeted imaging; ultrasound

PROJECT SUMMARY/ABSTRACT Over 40,000 children in the US are hospitalized for musculoskeletal deformities each year. Abnormal and often diminished skeletal growth is the root cause of many of these conditions. For years, periosteal resection has been shown to accelerate longitudinal bone growth. Previous attempts to surgically exploit this phenomenon as a growth accelerating therapeutic modality have produced variable results that have not justified the procedures’ surgical morbidity and has been a major barrier to widespread clinical use. Recently, we have developed technology capable of performing these procedures non-invasively. However, the current technology lacks the necessary targeting and imaging capabilities to measure and ensure proper energy delivery at the bone surface. Furthermore, the exact portion of the periosteum that must be injured to accelerate growth is unclear. Thus, in the first aim we will determine the component of the periosteum injured during open surgical periosteal resection responsible for physeal growth acceleration and in the second aim we will integrate targeting capabilities into our system to allow precise placement of energy on the periosteum to minimize adjacent soft tissue injury. At the completion of the proposed work, we will have furthered our goal of developing a simple, non-invasive method to modulate skeletal growth.

项目概要/摘要 美国每年有超过 40,000 名儿童因肌肉骨骼畸形而住院。异常且经常 骨骼生长减慢是许多这些疾病的根本原因。多年来，骨膜切除术 已被证明可以加速骨骼的纵向生长。以前曾尝试通过手术利用这种现象 作为一种生长加速治疗方式，已经产生了不同的结果，但这些结果并不能证明其合理性 手术的手术发病率一直是广泛临床应用的主要障碍。最近，我们有 开发了能够非侵入性执行这些程序的技术。然而，当前 技术缺乏必要的瞄准和成像能力来测量和确保适当的能量 在骨表面输送。此外，骨膜必须受伤的确切部分 加速增长尚不清楚。因此，在第一个目标中，我们将确定受伤骨膜的成分 在开放手术骨膜切除术期间，负责促进骨骺生长加速，在第二个目标中，我们 将把靶向功能集成到我们的系统中，以便将能量精确地放置在骨膜上 尽量减少邻近软组织损伤。完成拟议的工作后，我们将进一步实现我们的目标： 开发一种简单、非侵入性的方法来调节骨骼生长。