Knifeless Limb Lengthening: Critical Advancement of an Innovative Therapy

无刀肢体延长：创新疗法的关键进展

基本信息

批准号：
10355106
负责人：
Matthew A Halanski
金额：
$ 21.49万
依托单位：
UNIVERSITY OF NEBRASKA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-06-15 至 2023-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10355106
关键词：
Ablation Acceleration Address Advanced Development Anatomy Biomedical Engineering Bone Growth Bone Surface Child Child Care Childhood Clinical Complication Data Deformity Detection Dose Drug Targeting Ensure Evaluation Excision Fiber Focused Ultrasound Fracture Goals Growth Growth Disorders Individual Injury Innovative Therapy Limb structure Malignant neoplasm of liver Measurement Measures Mediating Methods Microscopic Modality Molecular Analysis Molecular Biology Morbidity - disease rate Musculoskeletal Nerve Nerve Crush Nerve Fibers Operative Surgical Procedures Orthopedic Surgery Orthopedics Patients Periosteum Physiologic pulse Plant Roots Precision therapeutics Procedures Proteolysis Quality of life Rehabilitation therapy Soft Tissue Injuries Somatotropin System Technology Therapeutic Tissues Transducers Ultrasonic Therapy Ultrasonics Ultrasonography Work bone healing imaging capabilities improved injured long bone minimally invasive new technology response skeletal soft tissue stem cell therapy success targeted imaging ultrasound

项目摘要

PROJECT SUMMARY/ABSTRACT Over 40,000 children in the US are hospitalized for musculoskeletal deformities each year. Abnormal and often diminished skeletal growth is the root cause of many of these conditions. For years, periosteal resection has been shown to accelerate longitudinal bone growth. Previous attempts to surgically exploit this phenomenon as a growth accelerating therapeutic modality have produced variable results that have not justified the procedures’ surgical morbidity and has been a major barrier to widespread clinical use. Recently, we have developed technology capable of performing these procedures non-invasively. However, the current technology lacks the necessary targeting and imaging capabilities to measure and ensure proper energy delivery at the bone surface. Furthermore, the exact portion of the periosteum that must be injured to accelerate growth is unclear. Thus, in the first aim we will determine the component of the periosteum injured during open surgical periosteal resection responsible for physeal growth acceleration and in the second aim we will integrate targeting capabilities into our system to allow precise placement of energy on the periosteum to minimize adjacent soft tissue injury. At the completion of the proposed work, we will have furthered our goal of developing a simple, non-invasive method to modulate skeletal growth.

项目摘要/摘要美国每年有40,000多名美国因肌肉骨骼畸形而住院的儿童。异常，经常骨骼生长减少是许多此类条件的根本原因。多年以来，骨膜切除有他被证明可以加速纵向骨生长。以前试图通过手术利用这种现象由于增长加速治疗方式已产生可变结果，但尚未证明手术的手术发病率一直是广泛临床使用的主要障碍。最近，我们有开发的技术能够非侵入性地执行这些程序。但是，电流技术缺乏必要的目标和成像功能来衡量和确保适当的能量在骨表面递送。此外，perosteum的确切部分必须受伤加速增长尚不清楚。在第一个目的中，我们将确定受伤的peper骨的成分在负责物理生长加速的开放式外科手术切除术中，在第二个目标中，我们将将靶向能力集成到我们的系统中，以使能量在骨膜上精确放置最小化相邻的软组织损伤。拟议工作完成时，我们将进一步实现我们的目标开发一种简单的非侵入性方法来调节骨骼生长。