AAOS/ORS The Physis: Fundamental Knowledge to a Fantastic Future Through Research - 2018 Research Symposium

AAOS/ORS Physis：通过研究获得美好未来的基础知识 - 2018 年研究研讨会

• 批准号: 9398421
• 负责人: Matthew A Halanski
• 金额: $ 2万
• 依托单位: AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9398421
• 关键词: Affect; Area; Basic Science; Bone Development; Bone Growth; Cartilage Diseases; Cells; Child; Childhood; Clinical; Clinical Medicine; Collaborations; Collagen; Communities; Complex; Deformity; Degenerative polyarthritis; Development; Developmental Bone Diseases; Disease; Embryology; Endocrine; Endocrinologist; Engineering; Epidemic; Epiphysial cartilage; Estrogens; Exposure to; Extracellular Matrix; Future; Genetic; Goals; Growth; Growth Disorders; Growth Factor; Histology; Hormones; Hospitalization; Human; Implant; Individual; Inflammatory Arthritis; Institution; Interdisciplinary Study; Intervention; Journals; Knowledge; Literature; Measures; Mechanics; Metabolic; Molecular; Molecular Biology; Musculoskeletal; Mutation; ORALIT; Obesity; Operative Surgical Procedures; Orthopedic Surgery procedures; Orthopedics; Participant; Pathology; Pathway interactions; Pharmacology; Physiology; Plant Roots; Population; Publications; Radiology Specialty; Rage; Regulation; Research; Research Personnel; Science; Skeleton; Somatropin; Specialist; Stimulus; Structure; Surgeon; Techniques; Time; Work; cell growth; design; insight; long bone; minimally invasive; multidisciplinary; novel; novel therapeutic intervention; obesity in children; pediatric patients; prevent; skeletal; symposium; trend

Project Summary/Abstract: While the structure of the physis, or growth plate, has been well described by histology and radiologic measures, its physiology remains a mystery. Investigators have probed the physis and defined its makeup of extracellular matrix, collagen, the presence of certain growth factors, and characterized the histomorphometry of its cells. Yet how these different entities interact normally and in the face of disease is not known. Currently, surgeons employ techniques to slow growth and use implants to harness growth to correct deformity; but the mechanisms behind these interventions are elusive. Basic concepts such as what stimulates growth and how it can be harnessed is unknown; this remains the holy grail of pediatric orthopaedics. This topic is timely as surgical intervention is trending toward minimally invasive treatments. By defining the mechanisms by which the matrix, cells, and growth factors interact, pharmacologic and surgical interventions can be developed. In addition, a disproportionate share of musculoskeletal physeal diseases are found in obese children. As the obesity epidemic rages in our pediatric population, more children will suffer the consequences of physeal diseases. Pediatric patients will benefit from a deeper knowledge of the physis, but there are benefits to the larger scientific community as well. Understanding the endocrine cascade that works on the physis could give insights into cartilage disease beyond children, such as osteoarthritis and inflammatory arthritis. In order to begin to further our understanding of the physis and develop treatments, we have developed a scientific symposium to allow experts in both basic science and clinical medicine to discuss current knowledge about the growth plate, the effects of various stimuli on its structure, and to design novel treatments for physeal disorders. This symposium will include summaries of the current literature, original research presentations, and open and directed discussions over a two day interactive forum. The content and findings of the symposium will then be disseminated and available to the public through publication in a relevant orthopaedic journal.

项目摘要/摘要： 虽然生长板或生长板的结构已被组织学和放射学很好地描述 测量，它的生理学仍然是一个谜。研究人员已经探测了骨赘，并确定了它的组成 细胞外基质、胶原、某些生长因子的存在以及组织形态计量学的表征 它的细胞。然而，这些不同的实体如何正常地以及在面对疾病时相互作用尚不清楚。目前， 外科医生使用技术来减缓生长，并使用植入物来利用生长来矫正畸形；但 这些干预背后的机制难以捉摸。基本概念，如什么刺激增长以及如何 能否被利用是未知的；这仍然是儿科矫形外科的圣杯。这一话题恰逢其时 手术干预正朝着微创治疗的方向发展。通过定义通过哪些机制 基质、细胞和生长因子相互作用，可以开发药物和外科干预措施。在……里面 此外，在肥胖儿童中发现了不成比例的肌肉骨骼骨赘疾病。作为 肥胖流行在我们的儿科人群中肆虐，更多的儿童将遭受真菌病的后果 疾病。儿科患者将受益于对骨赘的更深入了解，但对 更大的科学界也是如此。了解影响骨赘的内分泌级联反应可以给 对儿童以外的软骨疾病的洞察，如骨关节炎和炎症性关节炎。为了 为了进一步加深我们对骨赘的了解并开发治疗方法，我们开发了一种科学的 研讨会，让基础科学和临床医学的专家讨论关于 生长板，各种刺激对其结构的影响，并设计新的生长板治疗方法 精神错乱。本次研讨会将包括当前文献的总结、原创研究演示文稿和 在为期两天的互动论坛上公开并指导讨论。研讨会的内容和成果 然后将通过在相关整形外科杂志上发表的文章向公众传播和提供。