Planning a Regional Center of Research Excellence in Non-communicable Diseases in India

项目总结/摘要 本提案的总体目标是利用现有和新的伙伴关系和基础设施， 统一的、全国范围的、以人口和临床为基础的区域卓越研究中心（RCRE） 该组织致力于在印度预防和控制非传染性疾病。过去五 多年来，我们的团队已经启动了四个基于人群的队列/干预措施，作为良好的表型，生物， 与非传染性疾病风险因素有关的预期数据来源， 结果。我们建议建立一个全国统一的非传染性疾病研究网格， 将队列纳入现有的癌症登记处/研究所和临床中心网络。本两年期项目 将以北部的新德里（国家首都直辖区）和南部的金奈（泰米尔纳德邦）为重点， 建立在我们的南亚心脏代谢风险降低中心（CARRS）纵向监测研究基础上 以及位于这两个城市的癌症登记处/研究所。规划股内部 在这项应用中，我们将通过增强CARRS为RCRE开发癌症研究基础设施 从新德里和钦奈癌症登记处获得的癌症病例信息的队列数据。我们 将建立并开始使用三个共享核心来支持当前和未来的RCRE项目：1）a 生物储存库和实验室能力建设核心（“生物核心”），以支持生物标本的采购， 记录保存、处理和生物标志物分析; 2）数据管理和分析核心（“数据核心”） 促进队列、登记研究和临床研究中心之间的数据联系，并提供数据库开发， 维护和分析服务;以及3）实地研究方法核心（“实地核心”）， 获得多学科数据收集方法和工具。我们亦会进行培训需求评估 并实施培训计划，其中包括面对面和虚拟指导的研究机会， 博士前和博士后科学家;以及对研究人员， 登记处/研究所和实地访谈员。利用研究基础设施，测试三个核心， 为学员提供以研究为基础的实践经验，我们将开展三个示范项目。在 我们的第一个项目是开发和验证连接新德里和钦奈CARRS的标准化协议 与相应的癌症登记处进行比较。第二个项目将是一个混合方法研究， 与癌症相关的耻辱感的患病率和相关因素;调查癌症和糖尿病- 相关知识和心理障碍的诊断和治疗。第三个项目将是 糖尿病与口腔溃疡关系的分子特征和潜在途径的研究 CARRS口腔健康子研究中的肿瘤。

PROJECT SUMMARY/ABSTRACT The overall goal of this proposal is to leverage existing and new partnerships and infrastructure to develop a unified, country-wide, population- and clinic-based Regional Center for Research Excellence (RCRE) dedicated to the prevention and control of non-communicable diseases (NCDs) in India. Over the past five years, our team has initiated four population-based cohorts/interventions that serve as well-phenotyped, bio- banked, geographic information systems (GIS)-linked sources of prospective data on NCD risk factors and outcomes. We propose to develop a unified nationwide NCD research grid by linking these population-based cohorts to the existing network of cancer registries/institutes and clinical centers. The present 2-year project will focus on New Delhi (National Capital Territory) in the north and Chennai (Tamil Nadu State) in the south to build on our longitudinal Center for Cardiometabolic Risk Reduction in South Asia (CARRS) Surveillance Study and linkable population-based cancer registries/institutes located in these two cities. Within the Planning Unit of this application we will develop cancer research infrastructure for the RCRE by augmenting the CARRS cohort data with information on cancer cases obtained from the New Delhi and Chennai Cancer registries. We will establish and begin using three shared cores to support current and future RCRE projects: 1) a Biorepository and Laboratory Capacity Building Core (“Bio Core”) to support bio-specimen procurement, record-keeping, processing, and biomarker analysis; 2) a Data Management and Analytics Core (“Data Core”) to facilitate data linkages between cohort, registry, and clinical sites and offer database development and maintenance and analysis services; and 3) a Field Research Methodology Core (“Field Core”) to provide access to multi-disciplinary data collection methods and tools. We will also perform training needs assessment and implement training programs that will include in-person and virtually mentored research opportunities to pre- and post-doctoral scientists; and hands-on training to research personnel such as staff of registries/institutes and field interviewers. To utilize the research infrastructure, to test the three cores and to offer research-based practical experience to our trainees we will conduct three demonstration projects. In the first project we will develop and validate a standardized protocol to link the New Delhi and Chennai CARRS cohorts with the corresponding cancer registries. The second project will be a mixed methods study describing the prevalence and correlates of cancer-related perceived stigma; and investigating cancer- and diabetes- related knowledge and psychosocial barriers to diagnosis and treatment. The third project will be an investigation of molecular features and underlying pathways of the association between diabetes and oral neoplasia in CARRS Oral Health sub-study.