Core B

核心B

• 批准号: 9211436
• 负责人: Heather A Drummond
• 金额: $ 71.54万
• 依托单位: UNIVERSITY OF MISSISSIPPI MED CTR
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-08 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9211436
• 关键词: Back; Basic Science; Bioinformatics; Biological Assay; Biometry; Blood Pressure; Body Temperature; Businesses; Cells; Centers of Research Excellence; Charge; Childhood; Chronic; Clinical Research; Consanguinity; Data; Data Analyses; Development; Echocardiography; Enzyme-Linked Immunosorbent Assay; Equipment; Faculty; Fees; Fluorescence-Activated Cell Sorting; Fostering; Funding; Genomics; Goals; Gonadal Steroid Hormones; Grant; Guidelines; Heart Rate; Histology; Human Resources; Image; Immune; Maintenance; Measurement; Measures; Metabolic Diseases; Mississippi; Modeling; Morphology; Neonatal; Neurosciences; Perinatal; Population; Research; Research Personnel; Resources; Rodent; Services; Students; Supervision; T-Lymphocyte; Technical Expertise; Telemetry; Training; Ultrasonography; Universities; Wages; X-Ray Computed Tomography; analytical tool; equipment acquisition; fetal; genetic analysis; genetic pedigree; genomic data; improved; liquid chromatography mass spectroscopy; macrophage; novel; programs; ranpirnase

MISSISSIPPI CENTER OF EXCELLENCE IN PERINATAL RESEARCH (CEPR) RESEARCH RESOURCES CORE B SUMMARY The goal of the Research Resources Core B of the CEPR is to provide COBRE investigators and trainees with access to state-of-the-art equipment and technical expertise needed to perform their research. New Sub-cores that will be developed in this COBRE include a Pediatric Echocardiography (ECHO) Sub-core, a Telemetry Sub-Core, and a Fluorescence-Activated Cell Sorting (FACS) Sub-Core. There will also be a Biostatistics and Bioinformatics Sub-Core in Core B since there will be considerable genomic data that will need to be analyzed for Project IV and there is no capacity for this in the other COBREs. These sub-cores are novel and are not funded by the existing COBREs, the Cardiorenal and Metabolic Diseases Research COBRE (P20 GM104357) (CMDR) or the Center for Psychiatric Neurosciences COBRE (P30 GM103328) or the University of Southern Mississippi INBRE program. Additional resources will be put into existing CMDR COBRE Sub-Cores for use by the CEPR investigators, the Bioanalytical Sub-Core, the Genomics Core and the Histology and Imaging Sub- Core. The Specific Aims of the Research Resources Core B include the following: 1) To provide services that foster cutting edge clinical and basic research of the highest quality. 2) To provide a Pediatric Echocardiography Sub-Core that can perform both neonatal and fetal sonography. 3) To provide a centrally located, well-equipped Telemetry Sub-Core for the chronic measurement of blood pressure, heart rate, activity and body temperature in rodents. 4) To provide a well equipped Fluorescence-Activated Cell Sorting Sub-Core that can be used to separate immune cells, such as populations of T cells, macrophages, etc, into groups for analysis and quantification. 5) To provide Biostatistics and bioinformatics analyses of data collected in the Projects and by the Sub-Cores. 6) To provide maintenance and supervision of key equipment and provide training, technical support, and supervision for all investigators, staff and students in the proper utilization of Core B equipment. 7) To provide salary and supply support for the CMDR Genomics Sub Core Director to perform genomic analyses for consanguinity for Project IV. 8) To provide salary and supply support for the CMDR Liquid Chromatography/Mass Spectroscopy Sub-Core to develop and measure sex steroids for Project II and III. 9) To provide supply support for the CMDR Bioanalytical Subcore so as to allow the CEPR COBRE investigators to have access to cutting edge RIA and ELISA assays necessary for completion of their Projects I-III. 10) To provide supply support for the CMDR Histology and Imaging Sub-Core so junior investigators have access to state-of-the-art imaging (specifically, computed tomography), and histology and morphology. 11) To optimize all assays and core services, to provide improvement in existing assays and services, and to assist in the interpretation of results and data. 12) To develop a business model for Core B that is compliant with federal funding guidelines to provide support for sustainability of Core B services, equipment, and facilities. The services of Core B are absolutely necessary for the successful completion of the studies described in Projects I-IV and will be an asset to Pipeline grant investigators. Furthermore, any other UMMC investigators will have access to the Core B services on a charge-back fee basis.

密西西比州围产期研究卓越中心（CEPR） 研究资源核心B 总结 CEPR的研究资源核心B的目标是为COBRE研究人员和学员提供 获得进行研究所需的最先进的设备和技术专长。新的子核心 将在该COBRE中开发的功能包括儿科超声心动图（ECHO）子核心、遥测 子核心，和一个荧光激活细胞分选（FACS）子核心。还将有一个生物统计学和 核心B中的生物信息学子核心，因为需要分析大量的基因组数据 其他COBREs没有这方面的能力。这些子核是新颖的， 由现有的COBRE资助，肾脏和代谢疾病研究COBRE（P20 GM 104357） （CMDR）或精神神经科学中心COBRE（P30 GM 103328）或南方大学 密西西比INBRE计划。将向现有CMDR COBRE子核心投入额外资源， CEPR研究者，生物分析子核心，基因组学核心和组织学和成像子核心， 核心 研究资源核心B的具体目标包括： 1)提供促进最高质量的前沿临床和基础研究的服务。 2)提供一个可进行新生儿和胎儿超声检查的儿科超声心动图子核心。 3)提供一个位于中心位置、设备齐全的遥测子核心，用于长期血液测量 血压、心率、活动和体温。 4)为了提供一个装备精良的细胞活化细胞分选子核心，可用于分离 免疫细胞，如T细胞群、巨噬细胞等，分组用于分析和定量。 5)对项目和分核心收集的数据进行生物统计学和生物信息学分析。 6)提供关键设备的维护和监督，并提供培训，技术支持， 监督所有研究人员、工作人员和学生正确使用核心B设备。 7)为CMDR基因组学副核心总监提供工资和供应支持，以执行基因组学 项目四的血缘关系分析。 8)为CMDR液相色谱/质谱子核心提供工资和供应支持 为项目II和III开发和测量性类固醇。 9)为CMDR生物分析子核心提供供应支持，以便CEPR COBRE 研究人员能够获得完成其项目所需的尖端RIA和ELISA检测 第一至第三节。 10)为CMDR组织学和成像子核心提供供应支持，以便初级研究者 获得最先进的成像（特别是计算机断层扫描）以及组织学和形态学。 11)优化所有分析和核心服务，改进现有分析和服务， 协助解释结果和数据。 12)为核心B开发符合联邦资助指导方针的商业模式， 支持核心B服务、设备和设施的可持续性。 核心B的服务对于成功完成 项目I-IV将成为管道赠款调查人员的资产。此外，任何其他UMMC研究人员 可以按计费方式使用Core B服务。